Microperimetry is a clinical tool for measuring central visual function whilst the retina is continuously monitored and retinal testing locus adjusted for eye movements. Regulatory authorities are now considering outcomes of microperimetry as a valid clinical trials endpoint in certain retinal conditions because visual acuity does not always reflect disease progression. This project will validate various types of microperimeters and determine how they should be used to monitor macular diseases.
The Role Of Estrogen Signalling In The Development And Progress Of Neovascularisation In Macular Degeneration
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Age-related macular degeneration is a common eye disease. In the advanced stages of the disease, abnormal and leaky blood vessels form, causing permanent and severe vision loss. A novel treatment is the application of the sex hormone, estrogen, which could halt abnormal blood vessel growth in the eye. This project aims to confirm the protective effects of estrogen on eye health and whether mutations in estrogen-related genes alter the risk of vision loss due to abnormal blood vessel growth.
Glaucoma Causes Secondary Neurodegeneration In The Brain
Funder
National Health and Medical Research Council
Funding Amount
$380,891.00
Summary
Glaucoma is one of the commonest causes of irreversible blindness worldwide. The optic nerve have been considered as the primary site of glaucomatous damage. However, recent evidence suggests that glaucoma may not merely be an eye disease, because secondary changes have also been observed in the higher visual centres in glaucoma patients. In this proposed study, topographically related degeneration along the visual pathway will be monitored using advanced MRI technology.