Centre-surround interactions in ageing human vision. Australia has a rapidly ageing population. This project will study how ageing affects the visual perception of objects presented on non-uniform backgrounds. Our ability to discriminate objects from their backgrounds is key to most natural visual tasks. The visual processes involved are known as centre-surround interactions, and are considered fundamental building blocks to human perception. This project will significantly advance our knowledge ....Centre-surround interactions in ageing human vision. Australia has a rapidly ageing population. This project will study how ageing affects the visual perception of objects presented on non-uniform backgrounds. Our ability to discriminate objects from their backgrounds is key to most natural visual tasks. The visual processes involved are known as centre-surround interactions, and are considered fundamental building blocks to human perception. This project will significantly advance our knowledge of which spatial visual mechanisms are altered due to age, supplying key information for understanding and improving visual environments for the elderly, as well as increasing knowledge of the brain mechanisms susceptible to the ageing process.Read moreRead less
Wiring the retina for human vision - a single-cell behavioural approach. This project aims to combine optical and behavioural methods to explore how colour information is channelled from individual cone photoreceptors through the living human retina, to the brain. By non-invasively stimulating either a single cell or specific arrangements of cells, the project aims to contribute fundamental knowledge about how the retina is wired to inform our exquisite sense of colour and spatial vision. This u ....Wiring the retina for human vision - a single-cell behavioural approach. This project aims to combine optical and behavioural methods to explore how colour information is channelled from individual cone photoreceptors through the living human retina, to the brain. By non-invasively stimulating either a single cell or specific arrangements of cells, the project aims to contribute fundamental knowledge about how the retina is wired to inform our exquisite sense of colour and spatial vision. This understanding has consequences across a range of disciplines, including artificial vision systems such as driverless cars, retinal disease, and the processing of information through neuronal connections in general.Read moreRead less
Removing the blinkers: a wider study of the human eye. Peripheral aberrations, wide-field retinal imaging and optical parameters. This project will study peripheral (side vision) optics of the human eye and its role in the limits of visual performance. This will improve ocular measurements and contribute towards improved diagnosis and treatment of ocular diseases and short-sightedness.
The role of immune cells in controlling blood flow. The project aims to increase our understanding of how neurons in the central nervous system alter blood flow to meet their metabolic needs. Tight control of the retinal vasculature is crucial for maintaining normal vision. Unlike most blood vessels in the body, those in the retina and brain receive no direct neural control. Rather, they rely on support cells to communicate the needs of neurons. This project aims to examine whether resident immu ....The role of immune cells in controlling blood flow. The project aims to increase our understanding of how neurons in the central nervous system alter blood flow to meet their metabolic needs. Tight control of the retinal vasculature is crucial for maintaining normal vision. Unlike most blood vessels in the body, those in the retina and brain receive no direct neural control. Rather, they rely on support cells to communicate the needs of neurons. This project aims to examine whether resident immune cells called microglia regulate blood vessels in response to neural activity. This knowledge would improve our understanding of how blood vessels are controlled in the retina and brain. The results may guide the development of novel ways of examining blood vessel function.Read moreRead less
Thalamic inputs and cortical microcircuitry underlying the functional architecture of the visual cortex. This project seeks to reveal the fundamental circuitry of the visual cortex that enables visual perception. Such understanding is essential not only for explaining many perceptual disturbances, but also for providing a neuronal basis for developing functionally useful prostheses for the blind.
The mechanism for defocus-driven ocular growth. 30 per cent of the Australian young adult population (with much higher percentages in Asia) suffer from myopia, and while we know the retina senses defocus, we do not know how. The knowledge gained through this project will help the development of pharmaceuticals to control myopia and of developmental practices that minimise the chances of children becoming myopic.
Advanced methods for intraocular imaging. The ability to image the retina of the human eye at high resolution is fundamental to improving understanding of ocular physiology, ocular optics and disease diagnosis. This project applies the relatively new application of active optics to vision science. This project will investigate the advantages of using new beam shaping techniques for characterising the optics of the eye, improving retinal imagery and improving fixation stability. This project will ....Advanced methods for intraocular imaging. The ability to image the retina of the human eye at high resolution is fundamental to improving understanding of ocular physiology, ocular optics and disease diagnosis. This project applies the relatively new application of active optics to vision science. This project will investigate the advantages of using new beam shaping techniques for characterising the optics of the eye, improving retinal imagery and improving fixation stability. This project will achieve three-dimensional holography of human eyes and develop holography plates for correcting the aberrations of eyes. Expected outcomes are not-before experienced resolution images of the retina and better understanding of the optical characteristics of the refractive surfaces and media in the eye.Read moreRead less