Regulation of DNA synthesis and host evasion by Lentivirus Capsids. This project aims to investigate how a type of virus, exemplified by HIV, can synthesise DNA in the cytoplasm of a host cell, without triggering the cell’s innate immunity when DNA is detected outside the nucleus. It expects to advance understanding of the role of the virus’ protein shell in regulating DNA synthesis during infection. The project outcomes should include enhanced capacity for fundamental virus and cell biology re ....Regulation of DNA synthesis and host evasion by Lentivirus Capsids. This project aims to investigate how a type of virus, exemplified by HIV, can synthesise DNA in the cytoplasm of a host cell, without triggering the cell’s innate immunity when DNA is detected outside the nucleus. It expects to advance understanding of the role of the virus’ protein shell in regulating DNA synthesis during infection. The project outcomes should include enhanced capacity for fundamental virus and cell biology research in Australia. The project anticipates contributing to new tools for delivering genes to cells, benefiting therapeutic and biotechnology applications.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100525
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Mucus control: Applying concepts from bacteriophage-mucus interactions. This project aims to examine how mucus-adherent bacteriophage interact with bacteria in mucus as a mechanism to manipulate microbiomes. Bacterial infections at mucosal surfaces in animals are a serious global health threat. Traditionally antibiotics have been used to curb mucosal infections, but antibiotic resistance means new therapies are urgently needed. Bacteriophage – viruses that infect bacteria – can kill bacteria and ....Mucus control: Applying concepts from bacteriophage-mucus interactions. This project aims to examine how mucus-adherent bacteriophage interact with bacteria in mucus as a mechanism to manipulate microbiomes. Bacterial infections at mucosal surfaces in animals are a serious global health threat. Traditionally antibiotics have been used to curb mucosal infections, but antibiotic resistance means new therapies are urgently needed. Bacteriophage – viruses that infect bacteria – can kill bacteria and might provide a layer of antimicrobial immunity in animal mucus. The anticipated outcomes are resolving how bacteriophage control bacteria within mucus, and applying concepts to bioengineer mucosal microbiomes.Read moreRead less
The first integrated multimodal assay for the ultrasensitive detection of dengue contamination of blood. This project will develop the first screening test to check for dengue contamination of blood donations in Australia. This will help ensure safe, continued supply from blood donors, particularly in Queensland where dengue is on the rise.