Using ‘omic and digital technologies toward better fasciolosis control. In Australia, liver fluke disease caused by Fasciola hepatica causes major economic losses to livestock production. Triclabendazole is the most effective drug for parasite control, however, resistance to this drug has emerged and continues to spread in Australia. This project expects to create a novel resource to identify new drug targets, generate new knowledge about the genetic composition of F. hepatica populations and un ....Using ‘omic and digital technologies toward better fasciolosis control. In Australia, liver fluke disease caused by Fasciola hepatica causes major economic losses to livestock production. Triclabendazole is the most effective drug for parasite control, however, resistance to this drug has emerged and continues to spread in Australia. This project expects to create a novel resource to identify new drug targets, generate new knowledge about the genetic composition of F. hepatica populations and unravel the genetic determinants underlying triclabendazole resistance. The curation of functionally-annotated genetic data for F. hepatica populations will underpin the development of diagnostic tests, drugs and vaccines to deliver a new generation of intervention strategies to control liver fluke disease.Read moreRead less
Pioneering reproductive biotechnology innovations for equine breeding. This project aims to develop the world's first commercially viable system of in vitro fertilisation (IVF) for horses. The equine industry is seeking reproductive technologies that allow rapid genetic gain to improve the health, welfare and quality of progeny. This project will exploit recent breakthroughs in molecular and cell biology, veterinary practice and biotechnology, by assembling these research findings into practical ....Pioneering reproductive biotechnology innovations for equine breeding. This project aims to develop the world's first commercially viable system of in vitro fertilisation (IVF) for horses. The equine industry is seeking reproductive technologies that allow rapid genetic gain to improve the health, welfare and quality of progeny. This project will exploit recent breakthroughs in molecular and cell biology, veterinary practice and biotechnology, by assembling these research findings into practical systems and products optimised for successful production of foals in vitro. These technologies will boost the productivity and international competitiveness of Australia's equestrian sporting disciplines, and position the Australian biotechnology sector as global leaders in animal reproductive technologies. Read moreRead less
Artificial intelligence to explore and combat eukaryotic pathogens. The revolution in artificial intelligence (AI) provides unprecedented opportunities for integrative analyses of complex multi-omics data sets and for creating radically new strategies to control some of the world’s most serious animal diseases. In a strong partnership with international experts, we will use AI-based methods to make major conceptual advances in our understanding of eukaryotic pathogens and host-pathogen interacti ....Artificial intelligence to explore and combat eukaryotic pathogens. The revolution in artificial intelligence (AI) provides unprecedented opportunities for integrative analyses of complex multi-omics data sets and for creating radically new strategies to control some of the world’s most serious animal diseases. In a strong partnership with international experts, we will use AI-based methods to make major conceptual advances in our understanding of eukaryotic pathogens and host-pathogen interactions, discover the "choke-points" in biological pathways, and develop novel treatments, vaccines and diagnostics. This leap forward will substantially enhance the global profile of pathogen research in Australia, build major capacity in a priority area, and enable access to international research funding and networks.Read moreRead less
How do kangaroo herpesviruses jump to new host species? . This project aims to study alphaherpesviruses of kangaroos and other marsupials. These viruses cause outbreaks of severe disease in captive populations of marsupials when they are transmitted from natural hosts to new host species, but these cross-species transmission events are poorly understood. This project aims to study these viruses, and their capacity for cross-species transmission, using new approaches that consider herpesviruses a ....How do kangaroo herpesviruses jump to new host species? . This project aims to study alphaherpesviruses of kangaroos and other marsupials. These viruses cause outbreaks of severe disease in captive populations of marsupials when they are transmitted from natural hosts to new host species, but these cross-species transmission events are poorly understood. This project aims to study these viruses, and their capacity for cross-species transmission, using new approaches that consider herpesviruses as dynamic, mixed populations of viruses. This project also aims to develop novel, practical, and accessible vaccines to prevent disease. Benefits are expected to arise through prevention of disease in captive marsupial populations, including benefits for conservation efforts and for Australian tourism.
Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100594
Funder
Australian Research Council
Funding Amount
$447,914.00
Summary
Advancing chicken helminthology for sustainable worm control . Worm infections are a serious disease problem in free-range chicken production systems which now dominate egg production in Australia. This project aims to improve the control of worm infections of chickens by developing new tools for poultry researchers, advisors and farmers to use for this purpose. The project expects to develop novel methods for laboratory-based anthelmintic drug resistance testing, maintenance of defined worm str ....Advancing chicken helminthology for sustainable worm control . Worm infections are a serious disease problem in free-range chicken production systems which now dominate egg production in Australia. This project aims to improve the control of worm infections of chickens by developing new tools for poultry researchers, advisors and farmers to use for this purpose. The project expects to develop novel methods for laboratory-based anthelmintic drug resistance testing, maintenance of defined worm strains and diagnosis of infection. It will also determine the effectiveness of mass treatment in the field and the prevalence of anthelmintic resistance. Use of these tools and information will improve worm control and thus the productivity and welfare of free-range chickens in Australia and worldwide.Read moreRead less