Industrial Transformation Training Centres - Grant ID: IC220100050
Funder
Australian Research Council
Funding Amount
$4,508,426.00
Summary
ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance (ARC CEA-StAR). The ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance aims to develop industry-led solutions and train a new generation of researchers to combat the impact of antimicrobial resistance (AMR) on agribusiness and the environment.
AMR is a global health and economic threat that epitomises the need for a ‘One Health’ collaborative approach encompassi ....ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance (ARC CEA-StAR). The ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance aims to develop industry-led solutions and train a new generation of researchers to combat the impact of antimicrobial resistance (AMR) on agribusiness and the environment.
AMR is a global health and economic threat that epitomises the need for a ‘One Health’ collaborative approach encompassing the interconnection between people, animals, plants, and their shared environment.
Expected outcomes of this collaborative program include a cohort of researchers trained in industry-relevant techniques, furnishing solutions to partner-defined AMR challenges, and providing significant benefits by positioning Australia as a global leader in reducing AMR.Read moreRead less
Defining the molecular basis for Salmonella persistence. Salmonella infections in animals and humans place significant burdens on the agri-food and healthcare sectors. All mammals and avian species can become chronically infected with Salmonella and such chronic carriage is a reservoir for disease and outbreaks in other animals and humans. Significant gaps in our understanding of Salmonella infection remain, including the molecular mechanisms involved in establishing a chronic carrier state. We ....Defining the molecular basis for Salmonella persistence. Salmonella infections in animals and humans place significant burdens on the agri-food and healthcare sectors. All mammals and avian species can become chronically infected with Salmonella and such chronic carriage is a reservoir for disease and outbreaks in other animals and humans. Significant gaps in our understanding of Salmonella infection remain, including the molecular mechanisms involved in establishing a chronic carrier state. We identified several Salmonella specific genes and subsequent murine studies revealed that a Salmonella mutant lacking these genes is attenuated in mice and especially in the gallbladder. In this project we seek to understand the molecular basis for attenuation and the contribution of each protein to diseaseRead moreRead less