Treating Equine Laminitis. This project aims to explore the causes of equine laminitis, and to work with a newly-established Australian biopharma company to develop the world's first anti-laminitis medication. Equine laminitis is a painful, crippling disease of the foot, often necessitating euthanasia, and is the second-most common cause of death in domestic horses. In 2007, a landmark study identified insulin toxicity as a primary cause of laminitis, and subsequent research has identified over- ....Treating Equine Laminitis. This project aims to explore the causes of equine laminitis, and to work with a newly-established Australian biopharma company to develop the world's first anti-laminitis medication. Equine laminitis is a painful, crippling disease of the foot, often necessitating euthanasia, and is the second-most common cause of death in domestic horses. In 2007, a landmark study identified insulin toxicity as a primary cause of laminitis, and subsequent research has identified over-stimulation of the IGF-1 receptor as the most likely mechanism. This project aims to prove that mechanism and to develop an effective treatment.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100135
Funder
Australian Research Council
Funding Amount
$395,199.00
Summary
Understanding equine incretins: a novel approach to laminitis prevention. Laminitis is a crippling foot disease in horses which incurs significant economic and social costs. Recent studies have shown that persistently high insulin concentrations can trigger laminitis, and that high insulin levels are caused by the excessive release of hormones called incretins. This project aims to determine the role of incretins and their receptors in causing abnormal equine insulin secretion. The distribution ....Understanding equine incretins: a novel approach to laminitis prevention. Laminitis is a crippling foot disease in horses which incurs significant economic and social costs. Recent studies have shown that persistently high insulin concentrations can trigger laminitis, and that high insulin levels are caused by the excessive release of hormones called incretins. This project aims to determine the role of incretins and their receptors in causing abnormal equine insulin secretion. The distribution of equine incretin receptors will be described for the first time, and the consequences of incretin receptor binding will be characterised. Understanding equine incretin biology may lead to novel therapies for laminitis.Read moreRead less
Transdermal penetration of corticosteroids in the dog. Topical application of corticosteroids enhances drug concentration and effectiveness in the treatment of skin diseases. Most topical corticosteroid preparations have been developed for human use and are poorly efficacious or promote a high incidence of adverse effects in dogs. This project will characterize corticosteroid penetration through canine skin to permit the development of suitable topical formulations to more effectively control ....Transdermal penetration of corticosteroids in the dog. Topical application of corticosteroids enhances drug concentration and effectiveness in the treatment of skin diseases. Most topical corticosteroid preparations have been developed for human use and are poorly efficacious or promote a high incidence of adverse effects in dogs. This project will characterize corticosteroid penetration through canine skin to permit the development of suitable topical formulations to more effectively control skin diseases in the dog. Skin diseases are a significant problem in veterinary science and this project will not only provide an effective therapeutic option, but also reduce animal (and client) distress when suffering skin disease and/or adverse effects from traditional therapy.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100026
Funder
Australian Research Council
Funding Amount
$230,000.00
Summary
VetCompass: Big Data and Real-time Surveillance for Veterinary Science. VetCompass: big data and real-time surveillance for veterinary science:
The VetCompass data service intends to collect real-time records from veterinary clinics and aggregate them for researchers to interrogate. It aims to provide Australian researchers with sustainable and cost-effective access to authoritative data from hundreds of practitioners in Australia and the United Kingdom. These data will be essential for researc ....VetCompass: Big Data and Real-time Surveillance for Veterinary Science. VetCompass: big data and real-time surveillance for veterinary science:
The VetCompass data service intends to collect real-time records from veterinary clinics and aggregate them for researchers to interrogate. It aims to provide Australian researchers with sustainable and cost-effective access to authoritative data from hundreds of practitioners in Australia and the United Kingdom. These data will be essential for research on disease distribution and determinants, and surveillance and diagnostics that underpin evidence-based practice. The expected outcomes include identification of the most prevalent disorders and their causes and optimal treatments. The data may also revolutionise clinical auditing in Australia, help the veterinary profession to rank research priorities, and inform companion animal and equine curricula in our universities.Read moreRead less