Biotechnology applications in the veterinary pharmaceutical industry: Pharmacological manipulation of ovarian function in domestic animals. The purpose of this research is to develop a humane, simple, safe, effective means of sterilizing female domestic animals without the need for surgical intervention. This novel experimental strategy is to target the supply of dormant eggs in the ovaries of female mammals. Every female mammal is born with a finite supply of eggs in the ovarian cortex. These c ....Biotechnology applications in the veterinary pharmaceutical industry: Pharmacological manipulation of ovarian function in domestic animals. The purpose of this research is to develop a humane, simple, safe, effective means of sterilizing female domestic animals without the need for surgical intervention. This novel experimental strategy is to target the supply of dormant eggs in the ovaries of female mammals. Every female mammal is born with a finite supply of eggs in the ovarian cortex. These cells cannot divide and so when this store is exhausted, reproduction ceases. Our strategy is to develop pharmaceutical reagents that will destroy this dormant egg population, thereby rendering the animals instantaneously and irreversibly infertile.Read moreRead less
Evaluating the impact of new interdisciplinary interventions to enhance dog health to benefit community health outcomes in remote Indigenous communities. Indigenous health and welfare is of major concern for Australians. This project, which focuses on the dog, also recognises that the dog harbours a number of diseases that can infect humans. To maintain sustainable dog health programs to reduce disease in dogs, and, as a corollary, have positive impact on human health and welfare, culturally-rel ....Evaluating the impact of new interdisciplinary interventions to enhance dog health to benefit community health outcomes in remote Indigenous communities. Indigenous health and welfare is of major concern for Australians. This project, which focuses on the dog, also recognises that the dog harbours a number of diseases that can infect humans. To maintain sustainable dog health programs to reduce disease in dogs, and, as a corollary, have positive impact on human health and welfare, culturally-relevant, evidence-based education programs are critical. Dog health programs will indirectly improve the expectations, standards and self-worth of many Indigenous Australians. As a consequence, the national benefits include the development of environmentally sustainable Indigenous communities, and the strengthening of Australia's social and economic fabric especially in rural and remote areas.
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Immunological mechanisms underlying the protective immune responses induced by botulinum oil adjuvanted vaccine. Botulism is recognised as an important bacterial pathogen in commercial beef cattle in Australia and around the world. Development of affective, well-researched vaccine against Clostridium botulinum is a high priority for the cattle industry. A novel oil adjuvanted vaccine (Singvac from Fort Dodge Pty Ltd) has advantage over conventional vaccines as it provides full protection follo ....Immunological mechanisms underlying the protective immune responses induced by botulinum oil adjuvanted vaccine. Botulism is recognised as an important bacterial pathogen in commercial beef cattle in Australia and around the world. Development of affective, well-researched vaccine against Clostridium botulinum is a high priority for the cattle industry. A novel oil adjuvanted vaccine (Singvac from Fort Dodge Pty Ltd) has advantage over conventional vaccines as it provides full protection following a single administration. The aims of this study are to investigate the immunological mechanisms underlying the protective response by this novel vaccine using bovine and murine models. This study will discover new control measures for botulism in Australia.Read moreRead less
Effectiveness of Antimicrobial Stewardship in Australian Veterinary Clinics. Antimicrobial resistance threatens Australians' health, Australia's animal health and its reputation for providing safe and reliable food. Overuse of antimicrobials is a driver of antimicrobial resistance. This project aims to address the overuse of antimicrobials in animals by implementing antimicrobial stewardship in veterinary practices and developing methods of antimicrobial use surveillance. It is the first compreh ....Effectiveness of Antimicrobial Stewardship in Australian Veterinary Clinics. Antimicrobial resistance threatens Australians' health, Australia's animal health and its reputation for providing safe and reliable food. Overuse of antimicrobials is a driver of antimicrobial resistance. This project aims to address the overuse of antimicrobials in animals by implementing antimicrobial stewardship in veterinary practices and developing methods of antimicrobial use surveillance. It is the first comprehensive study to address and assess inappropriate use of antimicrobials in veterinary medicine- and is expected to improve quality use of antimicrobials by veterinarians and prolong the efficacy of antimicrobials in veterinary medicine. This presents a critical step in reducing community exposure to antimicrobial resistance.Read moreRead less