Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The pr ....Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The project will provide fundamental advances in our knowledge of the nutrient transport during pregnancy that is required to produce a healthy baby.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101615
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
How does viviparity evolve? Genetic perspectives from a unique model system. By integrating decades of Australian natural history research with the same technology that allowed researchers to sequence the genome of the woolly mammoth, this project seeks to uncover the genetic mechanisms responsible for the transition from egg-laying to live-bearing in reptiles.
The link between the angiogenesis of live birth and cancer: a lizard model. The possible link between live birth and cancer will be tested in this project. Lizards that express a growth factor that helps the growth of human cancer tumours will be studied to determine the action of the factor in a whole animal and in human cancer cells.
Evolution of cognition and sociality in vertebrates. This project aims to understand better the selective forces shaping cognition and sociality in animals and to determine if 'social intelligence' theory, which predicts more sophisticated cognition as species become increasingly social, provides a general explanation for the evolution of intelligence.
Developing Assisted Reproductive Technologies for the Conservation of Critically Endangered Australian Amphibians. Unprecedented rates of species extinction are of global concern. Although high extinction rates are reported for all vertebrate classes, amphibians are the most severely affected. Captive-breeding programs play a key role in maintaining populations of endangered amphibian species, but in most cases reproductive rates are too low to support long term re-introduction programmes. This ....Developing Assisted Reproductive Technologies for the Conservation of Critically Endangered Australian Amphibians. Unprecedented rates of species extinction are of global concern. Although high extinction rates are reported for all vertebrate classes, amphibians are the most severely affected. Captive-breeding programs play a key role in maintaining populations of endangered amphibian species, but in most cases reproductive rates are too low to support long term re-introduction programmes. This study aims to develop sophisticated Assisted Reproductive Technologies (ART) to enhance the propagation and genetic management of endangered Australian frog species. ART is a powerful new approach to ex situ conservation that, if integrated into existing captive breeding programs, will ensure the preservation of Australia’s unique amphibian biodiversity.Read moreRead less
Cane toads as a model system for demographic analysis and invasive-species control. How do impacts on juvenile stages within a population affect later ages? This project will exploit recently developed methods to control early life-history stages of cane toads to provide a better understanding of population ecology and develop more effective ways to control invasive cane toads.
Defining unconscious and artificial selection. In 1868 Charles Darwin proposed that the process of domestication can be divided into two independent selective processes we now call unconscious and artificial selection. In this project, we include the Australian dingo as a functional intermediate between the wild wolf and domestic dogs and test Darwin's hypothesis using modern molecular and statistical techniques. It is now widely accepted that the dingo was not domesticated by indigenous Austral ....Defining unconscious and artificial selection. In 1868 Charles Darwin proposed that the process of domestication can be divided into two independent selective processes we now call unconscious and artificial selection. In this project, we include the Australian dingo as a functional intermediate between the wild wolf and domestic dogs and test Darwin's hypothesis using modern molecular and statistical techniques. It is now widely accepted that the dingo was not domesticated by indigenous Australians and is therefore the ideal extant population for the project. The project is significant because it will be a critical test of Darwin's hypothesis. The outcome could be an improved understanding of the genomic basis for selection that can inform the process of domestication.Read moreRead less
Understanding the koala microbiome: unlocking the secrets of koala health and dietary specialisation, and successful husbandry and translocation. This project aims to discover how the composition and function of koala gastrointestinal microbial communities differ in space and time in response to the varying nutritional quality and chemical composition of koala diets. Using detailed chemical analysis, cutting edge metagenomic and bioinformatic pipelines and powerful approaches to study enzyme fun ....Understanding the koala microbiome: unlocking the secrets of koala health and dietary specialisation, and successful husbandry and translocation. This project aims to discover how the composition and function of koala gastrointestinal microbial communities differ in space and time in response to the varying nutritional quality and chemical composition of koala diets. Using detailed chemical analysis, cutting edge metagenomic and bioinformatic pipelines and powerful approaches to study enzyme functions in the koala’s gut, the investigators aims to reveal the role of microbes in detoxification of plant toxins and degradation of recalcitrant fibre fractions. The outcomes aim to facilitate the use of faecal transplants to improve digestive function for translocated and rehabilitated koalas, enhancing options for koala management and conservation.Read moreRead less
Cane toads in southern Australia: invasion dynamics and options for control. This project aims to investigate the spread of cane toads through southern Australia, an invasion front that has attracted far less research than the same species’ expansion through tropical regions, even though toads severely impact native wildlife in both areas. This project expects to generate new knowledge to determine why the rate of toad invasion is so much slower in New South Wales than in the tropics, and how be ....Cane toads in southern Australia: invasion dynamics and options for control. This project aims to investigate the spread of cane toads through southern Australia, an invasion front that has attracted far less research than the same species’ expansion through tropical regions, even though toads severely impact native wildlife in both areas. This project expects to generate new knowledge to determine why the rate of toad invasion is so much slower in New South Wales than in the tropics, and how best to modify newly-developed approaches to toad control to the conditions in southern Australia. Expected outcomes include predicting future trajectories of expansion, and identifying optimal approaches to toad control and impact mitigation. This should provide significant benefits for biodiversity conservation.Read moreRead less
Nutritional requirements of the critically endangered corroboree frog. This project aims to test the effect of dietary carotenoids on an extensive range of fitness-determining traits in the endangered southern corroboree frog. Unprecedented rates of species extinction have been reported for all vertebrates, with amphibians most severely affected. Captive breeding programs play a key role in amphibian conservation, yet there is a lack of knowledge regarding the nutritional requirements of threate ....Nutritional requirements of the critically endangered corroboree frog. This project aims to test the effect of dietary carotenoids on an extensive range of fitness-determining traits in the endangered southern corroboree frog. Unprecedented rates of species extinction have been reported for all vertebrates, with amphibians most severely affected. Captive breeding programs play a key role in amphibian conservation, yet there is a lack of knowledge regarding the nutritional requirements of threatened species. Manipulating captive nutrition is a cost-effective action that will permit recovery teams to more efficiently implement conservation actions. The findings will be of major benefit to amphibian conservation globally.Read moreRead less