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Field of Research : Toxicology (incl. Clinical Toxicology)
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Toxicology (incl. Clinical Toxicology) (19)
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  • Researchers (4)
  • Funded Activities (19)
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  • Funded Activity

    Discovering New Pathways To Improved Biotherapeutic Treatment Of Snakebite Envenoming.

    Funder
    National Health and Medical Research Council
    Funding Amount
    $314,644.00
    Summary
    Snakebite is a public health emergency affecting up to 5.4 million people a year, causing up to 125,000 deaths. This multidisciplinary project will develop a new generation of medicines for treating snakebites, using innovative design approaches supported by cutting edge science and novel production ideas. Directly focused on improving antivenom effectiveness in the treatment of snakebites in Australia, Africa and Papua New Guinea, the results will make Australia a world leader in this field.
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    Active Funded Activity

    Discovery Early Career Researcher Award - Grant ID: DE220100381

    Funder
    Australian Research Council
    Funding Amount
    $444,000.00
    Summary
    Facilitating detection of new psychoactive substances in wastewater. This project aims to develop and apply novel analytical methods for detecting new psychoactive substances (NPS) in wastewater. NPS are a dynamic, complex addition to the illicit drug market, and a persistent analytical challenge for wastewater analysis. This project expects to fill the current knowledge gap in detection and identification of these substances in wastewater. This will provide substantial benefits both to Australi .... Facilitating detection of new psychoactive substances in wastewater. This project aims to develop and apply novel analytical methods for detecting new psychoactive substances (NPS) in wastewater. NPS are a dynamic, complex addition to the illicit drug market, and a persistent analytical challenge for wastewater analysis. This project expects to fill the current knowledge gap in detection and identification of these substances in wastewater. This will provide substantial benefits both to Australia and internationally by aiding development of early warning drug monitoring systems, providing the rapid deployment of interventions to reduce drug-related harm in the local community, while facilitating law and government agencies to better direct resources.
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    Funded Activity

    A Randomised Controlled Trial Of Antivenom For Red-bellied Black Snake Envenoming

    Funder
    National Health and Medical Research Council
    Funding Amount
    $464,444.00
    Summary
    Muscle damage can result from snake bite, is irreversible and there is no specific treatment except antivenom. Red-bellied black snake bite provides a unique opportunity to study antivenom use in muscle damage in snake bite because this snake occurs across large population areas of NSW and Queensland. The study will determine if antivenom is effective and safe in red bellied black snake bite and whether it is therefore useful for other important snakes that cause muscle damage worldwide.
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    Funded Activity

    Prevention Of Drug Toxicities With Dichloroacetic Acid - The Implications For Cancer Chemotherapy

    Funder
    National Health and Medical Research Council
    Funding Amount
    $539,839.00
    Summary
    Many valuable cancer drugs have limited clinical use because of their toxic side effects. Our experiments with a new anti cancer drug called dichloroacetic acid (DCA) will determine if it can reduce the toxic effects of Cisplatin on the kidney and the effects of Doxorubicin on the heart.
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    Funded Activity

    A Randomized, Double-blinded Controlled Trial (RCT) Of A New Whole IgG, Equine Antivenom Compared To The Currently Used F(ab’)2 CSL Taipan Antivenom, For The Treatment Of Papuan Taipan (Oxyuranus Scutellatus) Envenoming In Papua New Guinea.

    Funder
    National Health and Medical Research Council
    Funding Amount
    $1,453,073.00
    Summary
    Snakebite is very common in Papua New Guinea (PNG), and many bites are caused by the Papuan taipan, a highly venomous snake found in the southern PNG savannah's. Current antivenom is expensive (US$1500) and many patients do not receive optimal treatment. We will conduct a randomised controlled trial of a new, low cost taipan antivenom developed specifically for PNG. The safety and efficacy of the new antivenom is compared to the existing product to determine if it is a suitable alternative.
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    Funded Activity

    Linkage Projects - Grant ID: LP100200276

    Funder
    Australian Research Council
    Funding Amount
    $258,182.00
    Summary
    Fate of micropollutants in water recycling: influence of dissolved organic matter. Access to safe drinking water is essential for the economic and social development of Australia. There is increasing interest in applying advanced water treatment processes, such as membrane filtration or ozonation, to treat secondary effluent to a potable standard. This project promotes improved organic pollutant removal and monitoring during advanced water treatment and will contribute to the National Research P .... Fate of micropollutants in water recycling: influence of dissolved organic matter. Access to safe drinking water is essential for the economic and social development of Australia. There is increasing interest in applying advanced water treatment processes, such as membrane filtration or ozonation, to treat secondary effluent to a potable standard. This project promotes improved organic pollutant removal and monitoring during advanced water treatment and will contribute to the National Research Priority goal, water - a critical resource, by providing the increased protection of receiving waters including rivers and seawater. Further, as very few studies consider the role of dissolved organic matter for organic pollutant fate in water reuse internationally, this project will help to advance Australia's position in science.
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    Funded Activity

    Pharmacokinetics And Pharmacodynamics In Acute Poisoning

    Funder
    National Health and Medical Research Council
    Funding Amount
    $7,000.00
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    Funded Activity

    Management And Risk Prediction Of Paracetamol Overdose

    Funder
    National Health and Medical Research Council
    Funding Amount
    $98,950.00
    Summary
    Paracetamol overdose is the most common pharmaceutical poisoning in developed countries and incidence is increasing in the developing world. Overdose can lead to liver failure and death. Our research will evaluate a novel antidote regimen and whether early cessation of antidote for paracetamol toxicity in a specific cohort is safe, with implications of decreasing time in hospital. We will also identify risk prediction tools to help early identification of patients needing intensive treatment
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    Funded Activity

    Translational Venom And Antivenom Research

    Funder
    National Health and Medical Research Council
    Funding Amount
    $2,499,702.00
    Summary
    Snake envenoming is a neglected tropical disease and results in numerous deaths, psychological problems and economic burden. Antivenoms aren't readily available in resource poor countries. The CRE will investigate the effects of venom and antivenom to improve understanding of human envenoming. It will also develop tests for early diagnosis of envenoming and undertake clinical trials of antivenom. These studies will be translated back into clinical practice to improve treatment of snake bites.
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    Funded Activity

    Improving Health Outcomes In Drug Overdose And Envenoming: Risk Assessment And Interventional Studies

    Funder
    National Health and Medical Research Council
    Funding Amount
    $772,209.00
    Summary
    The research aims to improve our understanding of the mechanisms and treatments for poisoning and envenoming. Observational studies measuring toxin levels will be done to investigate the effects of drug overdose and terrestrial and marine envenoming. Clinical trials will be done to investigate the benefit and safety of antivenom in snake/spider envenoming, antidotes and other treatments for drug overdose, including decontamination such as activated charcoal. Clinical studies will involve multipl .... The research aims to improve our understanding of the mechanisms and treatments for poisoning and envenoming. Observational studies measuring toxin levels will be done to investigate the effects of drug overdose and terrestrial and marine envenoming. Clinical trials will be done to investigate the benefit and safety of antivenom in snake/spider envenoming, antidotes and other treatments for drug overdose, including decontamination such as activated charcoal. Clinical studies will involve multiple hospitals across Australia.
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    Showing 1-10 of 19 Funded Activites

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