Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying ....Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying regulators of lipid metabolism. The large diversity in humans necessitate sufficient sample sizes to identify true genetic regulators, but to date techniques capturing phenotypic data (lipids) have been largely limited. It is anticipated that this study will identify new regulators of lipid metabolism in humans.Read moreRead less
Establishing Vibrio natriegens as Ultra-Rapid Host for Synthetic Biology. This project aims to harness Vibrio natriegens, the world’s fastest-growing bacterium, as a microbial cell factory for synthetic biology and biotechnology. The project expects to develop new genetic tools and genetically-engineered microbes that can rapidly transform cheap feedstocks, such as plastic waste, into valuable chemicals and bioplastics. Expected outcomes include new knowledge on the mechanisms driving V. natrieg ....Establishing Vibrio natriegens as Ultra-Rapid Host for Synthetic Biology. This project aims to harness Vibrio natriegens, the world’s fastest-growing bacterium, as a microbial cell factory for synthetic biology and biotechnology. The project expects to develop new genetic tools and genetically-engineered microbes that can rapidly transform cheap feedstocks, such as plastic waste, into valuable chemicals and bioplastics. Expected outcomes include new knowledge on the mechanisms driving V. natriegens’ rapid growth, as well as building Australian multidisciplinary research capacity in synthetic biology that can translate this potential into bio-manufacturing processes. Significant benefits include the means to cut plastic pollution in our environment and to provide the basis for a carbon-negative chemical industry.Read moreRead less
ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. The ARC Centre for the Mathematical Analysis of Cellular Systems aims to deliver the mathematics required to compute life. The Centre will deliver innovation in computational and mathematical biology and establish in silico biology alongside in vivo and in vitro biology. These models will allow us to understand the complexity of life at the cellu ....ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. The ARC Centre for the Mathematical Analysis of Cellular Systems aims to deliver the mathematics required to compute life. The Centre will deliver innovation in computational and mathematical biology and establish in silico biology alongside in vivo and in vitro biology. These models will allow us to understand the complexity of life at the cellular level and enable new ways of combining diverse and heterogenous data. This will allow us to understand the mechanisms underlying cellular behaviour, and to apply rational design engineering methods in order to control the dynamics of biological systems. Read moreRead less
About time; a new biology for the mineralocorticoid receptor . Temporal control of cell function aligns biological pathways with environmental cues and is critical for optimal heath in mammals. This project will shed light on how a hormone receptor, the MR, modulates time keeping of biological clock time in cells. We will bring together cutting edge genetic modals and bioinformatic approaches with a unique set of research models to define the interaction between the MR and the circadian clock a ....About time; a new biology for the mineralocorticoid receptor . Temporal control of cell function aligns biological pathways with environmental cues and is critical for optimal heath in mammals. This project will shed light on how a hormone receptor, the MR, modulates time keeping of biological clock time in cells. We will bring together cutting edge genetic modals and bioinformatic approaches with a unique set of research models to define the interaction between the MR and the circadian clock and its role in the normal biology of the heart. New data will significantly enhance our understanding of the biology of MR and cortisol for the circadian time keeping function in peripheral tissues, and gain a clearer understand how our heart cells adapt to environmental circadian disruptors such as shift work. Read moreRead less
Quiet sleep is for repair, active sleep is for learning. Sleep is thought to achieve many different functions, from brain waste clearance to regulating emotions and perception. Understanding sleep functions in animal models has been difficult because sleep has been typically reduced to a single state. Our discovery of distinct sleep stages in the fruit fly provides a powerful way to study how different conserved sleep functions are regulated. This project will use new strategies for manipulating ....Quiet sleep is for repair, active sleep is for learning. Sleep is thought to achieve many different functions, from brain waste clearance to regulating emotions and perception. Understanding sleep functions in animal models has been difficult because sleep has been typically reduced to a single state. Our discovery of distinct sleep stages in the fruit fly provides a powerful way to study how different conserved sleep functions are regulated. This project will use new strategies for manipulating sleep stages in flies to understand their respective physiology and functions. We will test our hypothesis that different categories of sleep functions have been segregated by evolution into different stages: a quiet stage concerned primarily with brain repair and an active stage important for learning.
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Uncovering a novel energy-sensing mechanism in the brain. This project aims to investigate a novel regulator of energy homeostasis in the brain, a protein kinase called SIK3. Energy homeostasis is essential for life as it ensures an adequate supply of fuel to cells of the body. This project intends to generate new knowledge about molecular switches to regulate energy homeostasis by using innovative gene technologies and transgenic animal models. The expected outcomes include generating fundament ....Uncovering a novel energy-sensing mechanism in the brain. This project aims to investigate a novel regulator of energy homeostasis in the brain, a protein kinase called SIK3. Energy homeostasis is essential for life as it ensures an adequate supply of fuel to cells of the body. This project intends to generate new knowledge about molecular switches to regulate energy homeostasis by using innovative gene technologies and transgenic animal models. The expected outcomes include generating fundamental insights into how SIK3 in the hypothalamic neurons regulates energy homeostasis. Benefits include improving population health and wellbeing, informing the development of new bio-medical technologies, and expanding the capabilities of Australia’s next generation of researchers.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100032
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Small Animal In Vivo Imaging Facility with microCT imaging capabilities . This project aims to establish a state-of-the-art small animal in vivo imaging facility with microCT imaging capabilities, which is the first of its kind in the regional growth area of Hunter New England and the Central Coast in NSW. This facility will provide high resolution and high-speed scanning of anatomical structures in 2D and 3D, which is expected to generate detailed knowledge of the fundamental biological process ....Small Animal In Vivo Imaging Facility with microCT imaging capabilities . This project aims to establish a state-of-the-art small animal in vivo imaging facility with microCT imaging capabilities, which is the first of its kind in the regional growth area of Hunter New England and the Central Coast in NSW. This facility will provide high resolution and high-speed scanning of anatomical structures in 2D and 3D, which is expected to generate detailed knowledge of the fundamental biological processes in humans and animals in real-time across longitudinal studies as well as improve animal welfare by addressing the 3Rs by reducing animal usage. This project will foster interdisciplinary local, national, and international research stemming from world-class research in this region. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100271
Funder
Australian Research Council
Funding Amount
$463,618.00
Summary
Coordinating gene expression and cell size: the role of feedback regulation. This project aims to reveal how human cells coordinate the kinetics of messenger RNA (mRNA) transcript production, processing and degradation at the single-cell level. It expects to generate significant new biological knowledge of gene regulation by combining innovative interdisciplinary research methodologies in genetics, single-molecule imaging, mathematical modelling and quantitative cell biology. Expected outcomes i ....Coordinating gene expression and cell size: the role of feedback regulation. This project aims to reveal how human cells coordinate the kinetics of messenger RNA (mRNA) transcript production, processing and degradation at the single-cell level. It expects to generate significant new biological knowledge of gene regulation by combining innovative interdisciplinary research methodologies in genetics, single-molecule imaging, mathematical modelling and quantitative cell biology. Expected outcomes include enhanced training of researchers and to build Australia’s capability in the rapidly expanding fields of RNA biology and high-throughput microscopy. This should provide significant benefits for a myriad of applications including health, agriculture and veterinary sciences.Read moreRead less
CellMechBio: the influence of cellular mechanobiology on organ development. Through a set of collaborative interdisciplinary application projects, with open scientific questions, this project aims to develop cutting edge mechanobiological mathematical models of organ development and function.
The expected outcomes of this project are a step-change in the fidelity of multicellular models of three-dimensional tissues and the scientific investigations into the mechanobiological processes regulating ....CellMechBio: the influence of cellular mechanobiology on organ development. Through a set of collaborative interdisciplinary application projects, with open scientific questions, this project aims to develop cutting edge mechanobiological mathematical models of organ development and function.
The expected outcomes of this project are a step-change in the fidelity of multicellular models of three-dimensional tissues and the scientific investigations into the mechanobiological processes regulating organ development, currently not possible, that these models support.
In addition to significant benefits from advances in fundamental mathematical and biological knowledge, this project plans to develop a mechanobiological modelling framework made available to the wider scientific community by an open source release.Read moreRead less