Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying ....Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying regulators of lipid metabolism. The large diversity in humans necessitate sufficient sample sizes to identify true genetic regulators, but to date techniques capturing phenotypic data (lipids) have been largely limited. It is anticipated that this study will identify new regulators of lipid metabolism in humans.Read moreRead less
Establishing Vibrio natriegens as Ultra-Rapid Host for Synthetic Biology. This project aims to harness Vibrio natriegens, the world’s fastest-growing bacterium, as a microbial cell factory for synthetic biology and biotechnology. The project expects to develop new genetic tools and genetically-engineered microbes that can rapidly transform cheap feedstocks, such as plastic waste, into valuable chemicals and bioplastics. Expected outcomes include new knowledge on the mechanisms driving V. natrieg ....Establishing Vibrio natriegens as Ultra-Rapid Host for Synthetic Biology. This project aims to harness Vibrio natriegens, the world’s fastest-growing bacterium, as a microbial cell factory for synthetic biology and biotechnology. The project expects to develop new genetic tools and genetically-engineered microbes that can rapidly transform cheap feedstocks, such as plastic waste, into valuable chemicals and bioplastics. Expected outcomes include new knowledge on the mechanisms driving V. natriegens’ rapid growth, as well as building Australian multidisciplinary research capacity in synthetic biology that can translate this potential into bio-manufacturing processes. Significant benefits include the means to cut plastic pollution in our environment and to provide the basis for a carbon-negative chemical industry.Read moreRead less