Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or t ....Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or the acute exacerbation of existing disease. The impact of these new technologies on the early diagnosis and improved triaging of patients in emergency departments is potentially profound and could result in improved healthcare outcomes for the patients and reduced admissions to hospital as well as the development of a substantial international market.Read moreRead less
Hybrid Sensor-based Physiological Control of an Implantable Rotary Blood Pump. With over 11 million people needing heart transplants worldwide and only 3000 donor hearts, an effective alternative therapy is needed. The Ventracor Ltd. rotary blood pump is one possible approach whereby a fully implantable mechanical device assists the failing heart. The innovative steps in this research proposal will be a means to robustly and safely control the speed of the pump to meet the metabolic needs of the ....Hybrid Sensor-based Physiological Control of an Implantable Rotary Blood Pump. With over 11 million people needing heart transplants worldwide and only 3000 donor hearts, an effective alternative therapy is needed. The Ventracor Ltd. rotary blood pump is one possible approach whereby a fully implantable mechanical device assists the failing heart. The innovative steps in this research proposal will be a means to robustly and safely control the speed of the pump to meet the metabolic needs of the body. Apart from the obvious health benefits for patients, this will provide the company with a huge market advantage that will also help to bolster the Australian medical device industry.Read moreRead less
Robust estimation of cardiac output and oxygen consumption from simple non-invasive physiological variables. We aim to develop robust mathematical and physiological models to estimate cardiac output and oxygen consumption of an exercising individual from simple non-invasive physiological parameters such as heart rate, respiration, body temperature and body movement (using multiple triaxial accelerometers).
The models developed will provide a better understanding of the human cardiovascular s ....Robust estimation of cardiac output and oxygen consumption from simple non-invasive physiological variables. We aim to develop robust mathematical and physiological models to estimate cardiac output and oxygen consumption of an exercising individual from simple non-invasive physiological parameters such as heart rate, respiration, body temperature and body movement (using multiple triaxial accelerometers).
The models developed will provide a better understanding of the human cardiovascular system response to exercise, and could be incorporated as part of a closed loop control system for cardiac pacemakers and/or heart assist devices.
Outcomes will include increased scientific knowledge, new robust models of the exercising cardiovascular /respiratory / thermoregulatory system and advanced biomedical instrumentation.
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Analysis, Optimization, and Control of Scanning Atomic Force Microscope Micro-Cantilever Probes. Atomic Force Microscopes (AFM's) are widely used for the examination of samples smaller than can be observed with an optical microscope. A tiny 'finger', only a few atoms wide at its sharpest point, is used to 'feel' the surface of a sample. This project aims to increase the resolution of AFM images by actively controlling the sensor probe dynamics.
Better quality AFM images would allow scientists ....Analysis, Optimization, and Control of Scanning Atomic Force Microscope Micro-Cantilever Probes. Atomic Force Microscopes (AFM's) are widely used for the examination of samples smaller than can be observed with an optical microscope. A tiny 'finger', only a few atoms wide at its sharpest point, is used to 'feel' the surface of a sample. This project aims to increase the resolution of AFM images by actively controlling the sensor probe dynamics.
Better quality AFM images would allow scientists to further investigate the atomic and molecular structure of such samples as: metals, polymers, cells, and proteins.
This research will contribute to the design of an Australian made Scanning Probe Microscope. Development of local expertise will provide a valuable resource for Australian scientific and industrial research.
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