Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100161
Funder
Australian Research Council
Funding Amount
$540,000.00
Summary
A multi-omics platform for molecular evolution and developmental biology. A multi-omics platform for molecular evolution and developmental biology: The proposed multi-omics platform will provide the computational environment (consisting of data, computer hardware, software and workflows) required to undertake large scale 'omics based research projects within molecular evolution and developmental biology. The platform architecture is designed to accommodate the requirements of data intensive rese ....A multi-omics platform for molecular evolution and developmental biology. A multi-omics platform for molecular evolution and developmental biology: The proposed multi-omics platform will provide the computational environment (consisting of data, computer hardware, software and workflows) required to undertake large scale 'omics based research projects within molecular evolution and developmental biology. The platform architecture is designed to accommodate the requirements of data intensive research in a collaborative environment where datasets, tools and workflows can be shared. Bringing together complementary expertise in molecular evolution and developmental biology, the platform will provide the opportunity to perform integrative analysis across genomes, transcriptomes, proteomes, metabalomes and epigenomes, providing a unique collaborative analytical platform for Australian researchers.Read moreRead less
Using venoms to map critical and evolutionary conserved vulnerabilities. We have developed and applied new functional genomic approaches to study venom evolution. Using CRISPR screening, we find that unrelated venoms act on cells by exploiting the same vulnerabilities. By functionally mapping these vulnerabilities for all venom classes, we can begin to develop universal venom antidotes. Conversely, much of what we know about venom mechanisms comes from a small percentage of the biodiversity with ....Using venoms to map critical and evolutionary conserved vulnerabilities. We have developed and applied new functional genomic approaches to study venom evolution. Using CRISPR screening, we find that unrelated venoms act on cells by exploiting the same vulnerabilities. By functionally mapping these vulnerabilities for all venom classes, we can begin to develop universal venom antidotes. Conversely, much of what we know about venom mechanisms comes from a small percentage of the biodiversity within a venom, and we have developed genomic tools to study the venom “dark matter”. This work will lead to the full molecular characterisation of venom biodiversity, and new venom components will be useful for research or as novel medicines.Read moreRead less