Structure-guided optimisation of light-driven microalgae cell factories. Every two hours Earth receives more solar energy than is required to power our entire global economy for a year. This project aims to engineer advanced single cell green algae for high-efficiency solar light capture, to power next-generation light-driven bio-manufacture. The significance is to advance industry-scale production of sustainable products using microalgae. This is economically, socially and environmentally benef ....Structure-guided optimisation of light-driven microalgae cell factories. Every two hours Earth receives more solar energy than is required to power our entire global economy for a year. This project aims to engineer advanced single cell green algae for high-efficiency solar light capture, to power next-generation light-driven bio-manufacture. The significance is to advance industry-scale production of sustainable products using microalgae. This is economically, socially and environmentally beneficial. Project outcomes are designed to advance the technology from high-value bio-manufacture in microalgae, such as pharmaceuticals (e.g. biologicals), to mid-value products (e.g. fine chemicals) through to low-cost products, such as renewable fuels to help deliver key UN Sustainable Development Goals.Read moreRead less
Mid-Career Industry Fellowships - Grant ID: IM230100154
Funder
Australian Research Council
Funding Amount
$1,049,904.00
Summary
Fungi Power: Designer Fungal Cell Factories for Advanced Biomanufacturing. This project aims to build an advanced biomanufacturing platform based on filamentous fungi in collaboration with industry. Using synthetic biology, the project expects to engineer superior fungal host strains customisable to the needs of the industry and to address their technological gaps. The expected outcomes include the development of cost-efficient and sustainable fungal-based bioprocesses for the companies to produ ....Fungi Power: Designer Fungal Cell Factories for Advanced Biomanufacturing. This project aims to build an advanced biomanufacturing platform based on filamentous fungi in collaboration with industry. Using synthetic biology, the project expects to engineer superior fungal host strains customisable to the needs of the industry and to address their technological gaps. The expected outcomes include the development of cost-efficient and sustainable fungal-based bioprocesses for the companies to produce products, such as fine chemicals, pharmaceutical actives and food ingredients. The project would provide significant benefits by enabling existing and emerging companies' commercial successes and competitiveness in global markets, creating new jobs and resulting in the growth of the bio-economy in Australia.Read moreRead less
Developing a new class of RNA delivery vehicle using synthetic virology. This project aims to develop robust protein cages derived from the empty shells of viruses, or capsids, to protect and deliver sensitive cargo such as RNA in agricultural settings. It will do so by directed evolution of non-infectious capsids in the lab. This will uncover the molecular mechanisms underpinning the response of viruses to chemical and biological signals and create a new class of RNA delivery vehicle. This synt ....Developing a new class of RNA delivery vehicle using synthetic virology. This project aims to develop robust protein cages derived from the empty shells of viruses, or capsids, to protect and deliver sensitive cargo such as RNA in agricultural settings. It will do so by directed evolution of non-infectious capsids in the lab. This will uncover the molecular mechanisms underpinning the response of viruses to chemical and biological signals and create a new class of RNA delivery vehicle. This synthetic biology approach combines virology and protein engineering to establish a platform biotechnology for stable and effective delivery. The project expects to demonstrate the potential of nature’s nanoparticles, virus capsids, to enhance the efficacy of RNA technologies in a wide range of applications.Read moreRead less