Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100016
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Synthetic Biology: from Genomics to Valuable Bioproducts. Genomics has led to the discovery of both the fine and gross characteristics of specific microbial physiologies. This project aims to take the genetic diversity inherent in microbial systems and exploit it for biotechnology applications, using the cutting-edge facilities available for synthetic biology. The acquisition of a long-read sequencing platform, droplet digital PCR machine, pulsed-field electrophoresis apparatus, DNA library syst ....Synthetic Biology: from Genomics to Valuable Bioproducts. Genomics has led to the discovery of both the fine and gross characteristics of specific microbial physiologies. This project aims to take the genetic diversity inherent in microbial systems and exploit it for biotechnology applications, using the cutting-edge facilities available for synthetic biology. The acquisition of a long-read sequencing platform, droplet digital PCR machine, pulsed-field electrophoresis apparatus, DNA library system and small scale bioreactor will address the limitations of short-read sequencing, large fragment cloning and gene expression technologies, currently creating bottlenecks for synthetic biologists.Read moreRead less
Advancing programmable genetic computation to control plant gene activity. Plants can sense diverse internal and external conditions and integrate them to appropriately tune their response and maximize fitness. Plant biotechnology relies heavily on manipulating gene activity to change cell functions and confer advantageous agronomic traits. However, our ability to control plant gene activity remains rudimentary, limiting our biotechnology capabilities. This project aims to develop synthetic gene ....Advancing programmable genetic computation to control plant gene activity. Plants can sense diverse internal and external conditions and integrate them to appropriately tune their response and maximize fitness. Plant biotechnology relies heavily on manipulating gene activity to change cell functions and confer advantageous agronomic traits. However, our ability to control plant gene activity remains rudimentary, limiting our biotechnology capabilities. This project aims to develop synthetic gene logic gates in plants, to enable the construction of programmable genetically-encoded computational functions that can sense and process customizable inputs to drive desired changes in plant function. This advance will underpin useful applications in plant biotechnology such as improved crop stress tolerance and yield.Read moreRead less