Impact of Biological Coatings on Nanoparticle–Immune Cell Interactions. Nanomaterials exposed to biological environments such as blood or lymph fluids rapidly adsorb a layer of biomolecules on their surface, forming a biomolecular corona, and profoundly altering their properties. This project aims to resolve the influence of biomolecular coronas on nanoparticle–immune cell interactions by combining particle engineering, immunology, proteomics and bioinformatic analysis. The project expected outc ....Impact of Biological Coatings on Nanoparticle–Immune Cell Interactions. Nanomaterials exposed to biological environments such as blood or lymph fluids rapidly adsorb a layer of biomolecules on their surface, forming a biomolecular corona, and profoundly altering their properties. This project aims to resolve the influence of biomolecular coronas on nanoparticle–immune cell interactions by combining particle engineering, immunology, proteomics and bioinformatic analysis. The project expected outcomes are to generate new knowledge in nanomaterial–immune cell behaviour and design principles for nanoparticles with prospective applications in the agricultural, veterinary and biomedical sectors.Read moreRead less
Bespoke nanomaterials for understanding nano-bio interactions under flow. This project aims to develop innovative scalable synthesis techniques to produce polymeric nanomaterials with controlled properties and characterise interactions between nanomaterials and cells under flow conditions. This project expects to generate new knowledge in priority research areas of nanotechnology, polymer chemistry and immunology. The outcome of this project is an original scalable and environmentally friendly t ....Bespoke nanomaterials for understanding nano-bio interactions under flow. This project aims to develop innovative scalable synthesis techniques to produce polymeric nanomaterials with controlled properties and characterise interactions between nanomaterials and cells under flow conditions. This project expects to generate new knowledge in priority research areas of nanotechnology, polymer chemistry and immunology. The outcome of this project is an original scalable and environmentally friendly technology, new knowledge of cell-nanomaterial interactions and new design principles for nanoparticles with potential future applications in drug delivery, immunology and nanomedicine. This project should provide significant benefits to polymer, nanomaterial and pharmaceutical research and industry in Australia.Read moreRead less
Origami with triblock copolymers. This project aims to develop new nanoparticles structures with optimised shapes for biological applications. Most nanoparticles developed for drug delivery are spherical. However, these are not always the most efficacious as they often encounter problems penetrating the living cell. Viruses which have evolved to highly effectively invade living cells are often elongated. The project aims to mimic these structures by using the self-assembly of polymers. Expected ....Origami with triblock copolymers. This project aims to develop new nanoparticles structures with optimised shapes for biological applications. Most nanoparticles developed for drug delivery are spherical. However, these are not always the most efficacious as they often encounter problems penetrating the living cell. Viruses which have evolved to highly effectively invade living cells are often elongated. The project aims to mimic these structures by using the self-assembly of polymers. Expected outcomes include a better understanding how various sizes, shapes and surface groups of the prepared nanoparticles interact with cells. The knowledge could assist in the creation of better drug carriers for more efficient disease treatment.Read moreRead less