Computational haemodynamics system for prediction of risk of rupture of cerebral aneurysms. Every year about 2000 Australians suffer a ruptured aneurysm in the brain and some 750 of these die within 4 weeks. Since there is an increase in the detection of unruptured aneurysms, especially in healthy young people, there is an urgent need to be able to decide which lead to rupture and to provide suitable treatment options. This project, which will provide markedly improved means of patient-specific ....Computational haemodynamics system for prediction of risk of rupture of cerebral aneurysms. Every year about 2000 Australians suffer a ruptured aneurysm in the brain and some 750 of these die within 4 weeks. Since there is an increase in the detection of unruptured aneurysms, especially in healthy young people, there is an urgent need to be able to decide which lead to rupture and to provide suitable treatment options. This project, which will provide markedly improved means of patient-specific risk determination for aneurysm rupture, will have significant impact in reducing associated costs on the national health burden due to cerebral hemorrhage and stroke, on community productivity and disability and on more efficient targeting of expensive and dangerous brain surgery.Read moreRead less
Unraveling Mechanisms Of Liver Transplant Tolerance
Funder
National Health and Medical Research Council
Funding Amount
$694,822.00
Summary
Liver transplants are unique amongst solid organs as they are spontaneously accepted across different individuals and induce acceptance of other organs from the same donor co-transplanted at the same time. Using a new mouse liver transplantation model, this proposal will elucidate how the liver tissue performs this function and identify new markers associated with tolerance in the blood of mice. This knowledge will be used to identify liver transplant patients with reduced rejection risk.
Systemic Safety: the meanings of behaviour in contexts of surgical care. This collaborative project aims to improve our understanding of interacting systems of communication, as exemplified by the context of surgery. Increasingly, adverse events in operative care are considered systemic rather than a product of system breakdown. Existing systems, and how they lead to adverse events, need to be made more explicit. We will describe surgical practice as a system of meaning-bearing systems, integra ....Systemic Safety: the meanings of behaviour in contexts of surgical care. This collaborative project aims to improve our understanding of interacting systems of communication, as exemplified by the context of surgery. Increasingly, adverse events in operative care are considered systemic rather than a product of system breakdown. Existing systems, and how they lead to adverse events, need to be made more explicit. We will describe surgical practice as a system of meaning-bearing systems, integrated from context to content to expression, and incorporating language and other symbolic systems. We will display the ensemble effects of choices in these systems and how they predispose towards or inhibit adverse outcomes through systemic networks.Read moreRead less