Development of metal probes for the selective recognition of DNA. Transition metal complexes with large aromatic ligands have recently been shown to bind DNA by intercalation. However, controversy continues over their base sequence and groove selectivity. We will synthesise a range of chiral metal complexes and screen these against combinatorial oligonucleotide libraries to determine their base sequence selectivity. The information obtained will help us design better intercalators that can be us ....Development of metal probes for the selective recognition of DNA. Transition metal complexes with large aromatic ligands have recently been shown to bind DNA by intercalation. However, controversy continues over their base sequence and groove selectivity. We will synthesise a range of chiral metal complexes and screen these against combinatorial oligonucleotide libraries to determine their base sequence selectivity. The information obtained will help us design better intercalators that can be used as sensitive molecular probes and may find application as antitumour drugs. Binding interaction between the complex and DNA will be studied by NMR spectroscopy.Read moreRead less
A new G-protein coupled receptor target for conotoxins. We aim to understand the interaction between venom components from the marine cone snail, a major source of potential drug leads, and a key receptor in nerve cell signalling. This receptor plays a role in many nervous system functions and has been proposed as a target for treating a range of diseases including pain, depression and drug addiction. It is critical that we understand this interaction so we can fully exploit the potential of the ....A new G-protein coupled receptor target for conotoxins. We aim to understand the interaction between venom components from the marine cone snail, a major source of potential drug leads, and a key receptor in nerve cell signalling. This receptor plays a role in many nervous system functions and has been proposed as a target for treating a range of diseases including pain, depression and drug addiction. It is critical that we understand this interaction so we can fully exploit the potential of these molecules as drug leads. The potential exists for multibillion dollar markets for these new drugs that could provide significant economic benefits to Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0238397
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
A ROBOTIC NMR SPECTROMETER FOR ACCELERATED DRUG DISCOVERY. The aim is to establish a facility that will use a robotic NMR instrument to help in the characterisation of drug-protein interactions and in the discovery of new drugs or agrichemicals. The significance is that with the wealth of new information arising on protein sequences from genomics programs there is an urgent need to accelerate the rate of discovery of ligands that bind to these proteins. Such ligands may provide useful drug lea ....A ROBOTIC NMR SPECTROMETER FOR ACCELERATED DRUG DISCOVERY. The aim is to establish a facility that will use a robotic NMR instrument to help in the characterisation of drug-protein interactions and in the discovery of new drugs or agrichemicals. The significance is that with the wealth of new information arising on protein sequences from genomics programs there is an urgent need to accelerate the rate of discovery of ligands that bind to these proteins. Such ligands may provide useful drug leads or help in defining the function of newly discovered proteins. The outcomes will be new knowledge on protein structure and function, and potentially, new bio-active molecules.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453671
Funder
Australian Research Council
Funding Amount
$133,770.00
Summary
NMR Facility for Natural Products Research. The aim is to establish a facility that will use high-field NMR and LC-NMR equipment to help in the characterisation of unknown compounds from natural products and in the discovery of new drugs and agrichemicals. The significance is that the facility will accelerate the rate of discovery of new bioactive molecules and will provide a wealth of new information on plant biodiversity. The outcomes will be new knowledge in natural products chemistry, and po ....NMR Facility for Natural Products Research. The aim is to establish a facility that will use high-field NMR and LC-NMR equipment to help in the characterisation of unknown compounds from natural products and in the discovery of new drugs and agrichemicals. The significance is that the facility will accelerate the rate of discovery of new bioactive molecules and will provide a wealth of new information on plant biodiversity. The outcomes will be new knowledge in natural products chemistry, and potentially, new bioactive molecules.Read moreRead less