Statistical Advances in the Post-Genome Era. Biologically relevant statistical foundations for post-genome biology and biotechnology will be developed. Specific goals of the topics include the development of accurate and more efficient algorithms for sequence alignments, improved models to maximise the accuracy of analyses for gene expression data and superior statistical methods for identification of complex gene networks that predispose an organism to disease. The Project will make significant ....Statistical Advances in the Post-Genome Era. Biologically relevant statistical foundations for post-genome biology and biotechnology will be developed. Specific goals of the topics include the development of accurate and more efficient algorithms for sequence alignments, improved models to maximise the accuracy of analyses for gene expression data and superior statistical methods for identification of complex gene networks that predispose an organism to disease. The Project will make significant contributions to the new and evolving priority research area of Bioinformation Science (including bioinformatics). Outcomes will include novel techniques for analysis and mining of post-genome data, with applications to developments in Bio-medicine and Bio-agricultureRead moreRead less
Dynamic prediction models in Australian rules football using real time performance statistics. The study is a collaborative venture with Champion Data, the Australian leader in the collection and transmission of real time sporting data, and official provider of the Australian Football League (AFL) statistics. The aim is to develop a real time on line predictive model for AFL football. The model will use the statistics Champion Data collect as the match progresses as inputs to continually updat ....Dynamic prediction models in Australian rules football using real time performance statistics. The study is a collaborative venture with Champion Data, the Australian leader in the collection and transmission of real time sporting data, and official provider of the Australian Football League (AFL) statistics. The aim is to develop a real time on line predictive model for AFL football. The model will use the statistics Champion Data collect as the match progresses as inputs to continually update estimates of the probabilities of various outcomes of interest such as the winner of the match and the margin of victory. The project will assist Champion in their strategic aim to provide an on line form guide.Read moreRead less
Statistical and computational methods using a multiscale approach for protein identification and quantification. Proteins are critically important in the onset and ongoing illness associated with disease. Key proteins may serve as markers to diagnose or predict the course of a disease, or even become the target of pharmaceuticals. Accurate, efficient and robust algorithms are a critical component in protein identification. This research provides novel statistical algorithms for protein identific ....Statistical and computational methods using a multiscale approach for protein identification and quantification. Proteins are critically important in the onset and ongoing illness associated with disease. Key proteins may serve as markers to diagnose or predict the course of a disease, or even become the target of pharmaceuticals. Accurate, efficient and robust algorithms are a critical component in protein identification. This research provides novel statistical algorithms for protein identification using multiscale analysis techniques. Their applications in the bio-medical field will enable Australian and international researchers to identify key proteins more accurately, than current methods, leading to improve health, medical, and biological research outcomes.Read moreRead less
Predicting Roll Angular Motion. The roll angular motion, or RAM, of a ship denotes its oscillation about its longitudinal axis, primarily caused by wave motion. The ability to predict RAM is of significant practical utility. For example, in defence-related work it plays a role in determining accuracy of weapons systems. We suggest a technique for predicting RAM. Our method borrows from both parametric and nonparametric statistics, in that a sinusoidal model is fitted to data but only over a ....Predicting Roll Angular Motion. The roll angular motion, or RAM, of a ship denotes its oscillation about its longitudinal axis, primarily caused by wave motion. The ability to predict RAM is of significant practical utility. For example, in defence-related work it plays a role in determining accuracy of weapons systems. We suggest a technique for predicting RAM. Our method borrows from both parametric and nonparametric statistics, in that a sinusoidal model is fitted to data but only over a short time interval. We show how to both assess and correct error. In particular, we propose methods for attaching probabilities to the accuracy of predictions.Read moreRead less
New statistical methods for identifying micro-ribonucleic acid (miRNA) regulatory networks. Understanding gene regulatory networks is critical in the understanding of fundamental biological systems. These networks have important implications for the discovery of fundamental mechanisms relating to the diagnosis and management of many illnesses. This research will provide new statistical methods to identify regulatory micro-ribonucleic acid modules and to understand their relationship in gene regu ....New statistical methods for identifying micro-ribonucleic acid (miRNA) regulatory networks. Understanding gene regulatory networks is critical in the understanding of fundamental biological systems. These networks have important implications for the discovery of fundamental mechanisms relating to the diagnosis and management of many illnesses. This research will provide new statistical methods to identify regulatory micro-ribonucleic acid modules and to understand their relationship in gene regulatory networks through multiple covariance estimation and multivariate classification techniques. My results should enable researchers to better understand the regulation underlying biological systems, leading to improved human health, medical and biological research outcomes.Read moreRead less