Discovery Early Career Researcher Award - Grant ID: DE210101549
Funder
Australian Research Council
Funding Amount
$395,775.00
Summary
A virtual platform for animal–human inhalation toxicity extrapolation. This project aims to remove the long-lasting barrier in extrapolating data from animals to humans by developing an integrated virtual platform. This project expects to fully resolve inhalation exposure differences in nasal airways between commonly used animal surrogates and humans, which could lay scientific underpinnings in developing rigorous interspecies data conversion schemes. Expected outcomes include a versatile inhala ....A virtual platform for animal–human inhalation toxicity extrapolation. This project aims to remove the long-lasting barrier in extrapolating data from animals to humans by developing an integrated virtual platform. This project expects to fully resolve inhalation exposure differences in nasal airways between commonly used animal surrogates and humans, which could lay scientific underpinnings in developing rigorous interspecies data conversion schemes. Expected outcomes include a versatile inhalation exposure risk assessment tool that can be implemented for any airway compartment, enhanced reliability of animal tests, reduced number of animals for testing. This should provide significant benefits in improving occupational health and safety and promoting National/International regulatory changes. Read moreRead less
An integrated model for assessing health effects of nanoparticle inhalation. This project aims to examine the associated risks of nanoparticle inhalation on heath by developing a toxicological predictive tool for health risk assessment. The outcomes of this research will lead to greatly improved preventative measures, thereby reducing occupational diseases and the health socio-economic burden of Australia.
A Multiscale Modelling Platform for Nanoparticle Inhalation Risk Assessment. This project aims to explore the health risks caused by nanoparticle inhalation and its penetration through respiratory mucus and tissue cells. Exposure to nanoparticles has the potential to cause serious and possibly fatal health effects. An understanding of nanoparticle toxicology would enable us to appropriately protect the public’s health and safety. The project plans to consider human respiratory anatomy and physio ....A Multiscale Modelling Platform for Nanoparticle Inhalation Risk Assessment. This project aims to explore the health risks caused by nanoparticle inhalation and its penetration through respiratory mucus and tissue cells. Exposure to nanoparticles has the potential to cause serious and possibly fatal health effects. An understanding of nanoparticle toxicology would enable us to appropriately protect the public’s health and safety. The project plans to consider human respiratory anatomy and physiology and use advanced computer modelling and experimental techniques to evaluate the health risk of exposure to the burgeoning number of nanomaterials found in consumer products. The expected outcome of the project is a predictive tool that determines nanoparticle exposure risk and its health consequences.Read moreRead less