Neural plasticity in older adult human vision. This project aims to expand our understanding of age related changes in brain function, specifically plasticity. The project will increase knowledge of the role of an inhibitory neurotransmitter GABA in visual plasticity. Expected outcomes include new knowledge regarding the regulation of brain function in adulthood, enabling future research and planning for societal benefit to older Australia.
Plasticity of gastrointestinal vagal afferents. The aim of this project is to identify how leptin modulates specific subtypes of vagal afferent within the gut and the plasticity of this system under different dietary conditions. This proposed project will substantially increase understanding of the interactions between leptin, known to influence food intake, and vagal afferent satiety signals. It will also increase understanding of how these interactions alter in obesity and ultimately provide t ....Plasticity of gastrointestinal vagal afferents. The aim of this project is to identify how leptin modulates specific subtypes of vagal afferent within the gut and the plasticity of this system under different dietary conditions. This proposed project will substantially increase understanding of the interactions between leptin, known to influence food intake, and vagal afferent satiety signals. It will also increase understanding of how these interactions alter in obesity and ultimately provide targets and/or concepts for the pharmacotherapy of obesity.Read moreRead less
Biologically-inspired detection, pursuit and interception of moving objects by unmanned aircraft systems. Although it is well known that aggressive honeybees are very effective at detecting, pursuing and intercepting moving targets, this behaviour has never been studied quantitatively. This project will use high-speed video cinematography to investigate this behaviour, to develop visual algorithms for the detection of moving targets, and to create dynamical models of the mechanisms that control ....Biologically-inspired detection, pursuit and interception of moving objects by unmanned aircraft systems. Although it is well known that aggressive honeybees are very effective at detecting, pursuing and intercepting moving targets, this behaviour has never been studied quantitatively. This project will use high-speed video cinematography to investigate this behaviour, to develop visual algorithms for the detection of moving targets, and to create dynamical models of the mechanisms that control pursuit. The resulting algorithms will be incorporated into unmanned aerial vehicles for detecting, monitoring and tracking other objects in the sky, and their performance will be evaluated. The results will provide a better understanding of the biological basis of pursuit behaviour, as well as lead to novel technologies for aerial surveillance and safety.Read moreRead less
The retina lines the back of the eye and sends multiple movies of the visual world to the brain. This project aims to investigate how these multiple information channels are created. Descriptions of the basic pattern of wiring in the healthy retina will help clinical researchers to understand the disruptions that occur in visual disease. The precision of normal retinal wiring also delineates the precision required to restore normal function to a diseased or degenerating eye.
A role for sleep in optimising attention. All animal brains are prediction machines, which allows even tiny flies to effectively navigate complex environments. To predict what will happen next is important for guiding attention, but also for detecting anything surprising. This project aims to understand how prediction is optimized by sleep in Drosophila flies. We aim to use electrophysiology and calcium imaging to map visual prediction error signals across the fly brain, and then determine how g ....A role for sleep in optimising attention. All animal brains are prediction machines, which allows even tiny flies to effectively navigate complex environments. To predict what will happen next is important for guiding attention, but also for detecting anything surprising. This project aims to understand how prediction is optimized by sleep in Drosophila flies. We aim to use electrophysiology and calcium imaging to map visual prediction error signals across the fly brain, and then determine how genetically controlled delivery of sleep regulates the quality and distribution of these signals. This knowledge will benefit our understanding of how brains balance a capacity for prediction versus surprise, by examining how evolution has solved this difficult problem in the smallest brains.Read moreRead less
Strategies for mid-air collision avoidance in aircraft: lessons from bird flight. Birds seldom collide with each other and other objects, despite the high speeds at which they fly in complex environments. This project will examine how birds sense and avoid impending collisions, and will use these results to design novel strategies for the detection and avoidance of aircraft mid-air collisions.
Pharmacological modification of retinal and visual function and relation to control of refractive error. Myopia (short-sightedness) affects many hundreds of millions of people worldwide and can lead to blindness. Drug treatments that prevent myopia are being developed, however there is no efficient way of determining who is at risk of myopia or who will benefit from these treatments. This fundamental research project will determine the retinal and visual effects of pharmacologic agents that inhi ....Pharmacological modification of retinal and visual function and relation to control of refractive error. Myopia (short-sightedness) affects many hundreds of millions of people worldwide and can lead to blindness. Drug treatments that prevent myopia are being developed, however there is no efficient way of determining who is at risk of myopia or who will benefit from these treatments. This fundamental research project will determine the retinal and visual effects of pharmacologic agents that inhibit myopia, with the aim of determining an ocular measure that is related to myopia, which is altered by drugs that are known to slow myopia progression, and that could be used as an indication of an agent's likely effectiveness.Read moreRead less
Improved effectiveness of cochlear implants through new simultaneous stimulation techniques. Cochlear implants have brought the gift of hearing to 250,000 people worldwide and are an excellent example of Australian innovation. This project will examine an improved "high fidelity" stimulation strategy with the objective of defining a safe stimulus range for clinical use and providing a commercial advantage for Cochlear Ltd.
ARC Centre of Excellence - Vision Science. This Centre will generate important new knowledge of the performance, logic and stability of vision and visual behaviour. This knowledge will help reduce the burden of vision impairment in Australia, increasing productivity, promoting healthy ageing and reducing the community costs of visual impairment (ca. $9.85 billion in 2004). The knowledge produced will also make possible world-class innovations in robotics, leading to novel automated vision system ....ARC Centre of Excellence - Vision Science. This Centre will generate important new knowledge of the performance, logic and stability of vision and visual behaviour. This knowledge will help reduce the burden of vision impairment in Australia, increasing productivity, promoting healthy ageing and reducing the community costs of visual impairment (ca. $9.85 billion in 2004). The knowledge produced will also make possible world-class innovations in robotics, leading to novel automated vision systems with applications in industry and national security. Other knowledge will develop novel diagnostic technologies, for application in health delivery.Read moreRead less
Operation of nerve cell networks in the neocortex. In humans, intellectual disabilities occur when nerve cells in the neocortex, the most complicated area of the brain, fail to function correctly. The goal of this project is to understand how neocortical areas communicate and how changes in the structure of neurons disturb their function; work that will lead to a better understanding of the operation of the neocortex.