Plasticity of gastrointestinal vagal afferents. The aim of this project is to identify how leptin modulates specific subtypes of vagal afferent within the gut and the plasticity of this system under different dietary conditions. This proposed project will substantially increase understanding of the interactions between leptin, known to influence food intake, and vagal afferent satiety signals. It will also increase understanding of how these interactions alter in obesity and ultimately provide t ....Plasticity of gastrointestinal vagal afferents. The aim of this project is to identify how leptin modulates specific subtypes of vagal afferent within the gut and the plasticity of this system under different dietary conditions. This proposed project will substantially increase understanding of the interactions between leptin, known to influence food intake, and vagal afferent satiety signals. It will also increase understanding of how these interactions alter in obesity and ultimately provide targets and/or concepts for the pharmacotherapy of obesity.Read moreRead less
Biologically-inspired detection, pursuit and interception of moving objects by unmanned aircraft systems. Although it is well known that aggressive honeybees are very effective at detecting, pursuing and intercepting moving targets, this behaviour has never been studied quantitatively. This project will use high-speed video cinematography to investigate this behaviour, to develop visual algorithms for the detection of moving targets, and to create dynamical models of the mechanisms that control ....Biologically-inspired detection, pursuit and interception of moving objects by unmanned aircraft systems. Although it is well known that aggressive honeybees are very effective at detecting, pursuing and intercepting moving targets, this behaviour has never been studied quantitatively. This project will use high-speed video cinematography to investigate this behaviour, to develop visual algorithms for the detection of moving targets, and to create dynamical models of the mechanisms that control pursuit. The resulting algorithms will be incorporated into unmanned aerial vehicles for detecting, monitoring and tracking other objects in the sky, and their performance will be evaluated. The results will provide a better understanding of the biological basis of pursuit behaviour, as well as lead to novel technologies for aerial surveillance and safety.Read moreRead less
The retina lines the back of the eye and sends multiple movies of the visual world to the brain. This project aims to investigate how these multiple information channels are created. Descriptions of the basic pattern of wiring in the healthy retina will help clinical researchers to understand the disruptions that occur in visual disease. The precision of normal retinal wiring also delineates the precision required to restore normal function to a diseased or degenerating eye.
Strategies for mid-air collision avoidance in aircraft: lessons from bird flight. Birds seldom collide with each other and other objects, despite the high speeds at which they fly in complex environments. This project will examine how birds sense and avoid impending collisions, and will use these results to design novel strategies for the detection and avoidance of aircraft mid-air collisions.
Pharmacological modification of retinal and visual function and relation to control of refractive error. Myopia (short-sightedness) affects many hundreds of millions of people worldwide and can lead to blindness. Drug treatments that prevent myopia are being developed, however there is no efficient way of determining who is at risk of myopia or who will benefit from these treatments. This fundamental research project will determine the retinal and visual effects of pharmacologic agents that inhi ....Pharmacological modification of retinal and visual function and relation to control of refractive error. Myopia (short-sightedness) affects many hundreds of millions of people worldwide and can lead to blindness. Drug treatments that prevent myopia are being developed, however there is no efficient way of determining who is at risk of myopia or who will benefit from these treatments. This fundamental research project will determine the retinal and visual effects of pharmacologic agents that inhibit myopia, with the aim of determining an ocular measure that is related to myopia, which is altered by drugs that are known to slow myopia progression, and that could be used as an indication of an agent's likely effectiveness.Read moreRead less
Improved effectiveness of cochlear implants through new simultaneous stimulation techniques. Cochlear implants have brought the gift of hearing to 250,000 people worldwide and are an excellent example of Australian innovation. This project will examine an improved "high fidelity" stimulation strategy with the objective of defining a safe stimulus range for clinical use and providing a commercial advantage for Cochlear Ltd.
ARC Centre of Excellence - Vision Science. This Centre will generate important new knowledge of the performance, logic and stability of vision and visual behaviour. This knowledge will help reduce the burden of vision impairment in Australia, increasing productivity, promoting healthy ageing and reducing the community costs of visual impairment (ca. $9.85 billion in 2004). The knowledge produced will also make possible world-class innovations in robotics, leading to novel automated vision system ....ARC Centre of Excellence - Vision Science. This Centre will generate important new knowledge of the performance, logic and stability of vision and visual behaviour. This knowledge will help reduce the burden of vision impairment in Australia, increasing productivity, promoting healthy ageing and reducing the community costs of visual impairment (ca. $9.85 billion in 2004). The knowledge produced will also make possible world-class innovations in robotics, leading to novel automated vision systems with applications in industry and national security. Other knowledge will develop novel diagnostic technologies, for application in health delivery.Read moreRead less
Operation of nerve cell networks in the neocortex. In humans, intellectual disabilities occur when nerve cells in the neocortex, the most complicated area of the brain, fail to function correctly. The goal of this project is to understand how neocortical areas communicate and how changes in the structure of neurons disturb their function; work that will lead to a better understanding of the operation of the neocortex.
Deep Downunder: designing a deep-sea exploration and discovery capability for Australia. Exploration of the deep-sea with the modern technologies to be developed by Deep-Downunder is a first for Australia. We aim to explore and discover life at depths from 50-3000m off The Great Barrier Reef, around the seamounts of Lord Howe Island and Tasmania and in the deep canyons of WA and SA. We expect to discover new species, hope for a glimpse of giant squid at home and will answer specific questions on ....Deep Downunder: designing a deep-sea exploration and discovery capability for Australia. Exploration of the deep-sea with the modern technologies to be developed by Deep-Downunder is a first for Australia. We aim to explore and discover life at depths from 50-3000m off The Great Barrier Reef, around the seamounts of Lord Howe Island and Tasmania and in the deep canyons of WA and SA. We expect to discover new species, hope for a glimpse of giant squid at home and will answer specific questions on Australia's ocean biology, fisheries and biotechnology never before approachable. To be effective guardians of Australian waters we must learn what lies in the depths we can't see from a boat.Read moreRead less
The roles of spectral cues and auditory plasticity in auditory localisation, speech segregation and speech intelligibility. Our recent work shows that high frequency energy in speech is important for the localisation of speech and may also aid in improving speech intelligibility in noisy environments. The work proposed here will systematically explore this somewhat surprising new finding and the results will be incorporated into a predictive model of speech intelligibility under spatial listenin ....The roles of spectral cues and auditory plasticity in auditory localisation, speech segregation and speech intelligibility. Our recent work shows that high frequency energy in speech is important for the localisation of speech and may also aid in improving speech intelligibility in noisy environments. The work proposed here will systematically explore this somewhat surprising new finding and the results will be incorporated into a predictive model of speech intelligibility under spatial listening conditions. This work includes a systematic study of auditory functional plasticity to changes in the spatial cues. Taken together, the outcomes of this work will unlock a range of new approaches to enhancing spatial hearing in multi-channel communication devices and spatial hearing aids.Read moreRead less