Operation of nerve cell networks in the neocortex. In humans, intellectual disabilities occur when nerve cells in the neocortex, the most complicated area of the brain, fail to function correctly. The goal of this project is to understand how neocortical areas communicate and how changes in the structure of neurons disturb their function; work that will lead to a better understanding of the operation of the neocortex.
Resolving multi-sensory conflict as we age: audio-visual integration and the role of normal and abnormal sensory decline. Australia has an ageing population. Even the healthiest older individuals undergo some deterioration of vision and hearing, however, these senses are almost invariably studied in isolation. The real world is multisensory. This project will enhance our knowledge of how ageing impacts on the interpretation of visual and auditory information regarding the timing and location of ....Resolving multi-sensory conflict as we age: audio-visual integration and the role of normal and abnormal sensory decline. Australia has an ageing population. Even the healthiest older individuals undergo some deterioration of vision and hearing, however, these senses are almost invariably studied in isolation. The real world is multisensory. This project will enhance our knowledge of how ageing impacts on the interpretation of visual and auditory information regarding the timing and location of objects; essential precursors to many real world tasks, for example: driving, interpreting speech, and hazard avoidance. This knowledge is essential for the optimisation of audio-visual environments for the elderly, and for the development of tools to improve performance in the presence of sensory decline due to age-related eye disease.Read moreRead less
Parallel and generative binding in human visual cortex. Imagine watching a group of children running around in brightly coloured T-shirts. How does your brain keep track of which colour goes with which T-shirt goes with which child? This project will use magnetic resonance imaging to identify where in our brains information about colour, shape and motion gets put together.
The neuronal bases of consciousness and attention. Why and how do some electrical activities in the brain make us see, hear and feel pain? Why other neural activities remain non-conscious? This project will utilise visual illusions combined with a range of state-of-the-art neuroimaging techniques to understand what kind of neuronal mechanisms underlie attention and consciousness.
From insects to robots: how brains make predictions and ignore distractions. This project aims to address fundamental questions in neuroscience and to integrate this biological understanding with the development of leading-edge robotics. Whether a human catching a ball or a dragonfly feeding in a swarm, brains have the remarkable ability to predict the future location of moving targets. The brain predicts in the presence of distractions and even if the target disappears, for example, when hidden ....From insects to robots: how brains make predictions and ignore distractions. This project aims to address fundamental questions in neuroscience and to integrate this biological understanding with the development of leading-edge robotics. Whether a human catching a ball or a dragonfly feeding in a swarm, brains have the remarkable ability to predict the future location of moving targets. The brain predicts in the presence of distractions and even if the target disappears, for example, when hidden behind another object. This project will investigate how brains use both environmental and internal information to select a target and predict its future location. By implementing bio-inspired computations in hardware, this project aims to provide significant benefits such as improving autonomous systems for defence, health and transportation.Read moreRead less
Target detection: neural networks, behaviour and biomimetic applications. This project aims to understand the neural and behavioural mechanisms that allow insects to efficiently detect moving targets in visual clutter, despite being equipped with small brains and low-resolution eyes. The project is expected to generate fundamental knowledge using a unique combination of quantitative behaviour, neurophysiology, pharmacological intervention and biomimetic modelling. Expected outcomes include an in ....Target detection: neural networks, behaviour and biomimetic applications. This project aims to understand the neural and behavioural mechanisms that allow insects to efficiently detect moving targets in visual clutter, despite being equipped with small brains and low-resolution eyes. The project is expected to generate fundamental knowledge using a unique combination of quantitative behaviour, neurophysiology, pharmacological intervention and biomimetic modelling. Expected outcomes include an increased understanding of neural mechanisms underlying sensory selectivity, the development of novel techniques, and enhanced capacity for interdisciplinary collaborations. The project will provide significant knowledge as the developed biomimetic algorithms should be applicable for increased performance in drones or other unmanned vehicles.Read moreRead less
Real-time friction sensing, feedback and control for dexterous prosthetic and robotic manipulation. Prosthetic and robotic hands demonstrate poor dexterity during object manipulation, often dropping objects. Humans rarely allow objects to slip because we can sense when an object is slippery and adjust our grip. Exceptionally little research has been directed at replicating this ability to sense friction. This project aims to enable artificial hands to estimate frictional properties while graspin ....Real-time friction sensing, feedback and control for dexterous prosthetic and robotic manipulation. Prosthetic and robotic hands demonstrate poor dexterity during object manipulation, often dropping objects. Humans rarely allow objects to slip because we can sense when an object is slippery and adjust our grip. Exceptionally little research has been directed at replicating this ability to sense friction. This project aims to enable artificial hands to estimate frictional properties while grasping an object. Non-invasive methods to feed back this frictional information to an amputee will also be investigated. Finally, the friction-sensing system will be used to improve robotic gripper control. The outcomes of this research will significantly advance the fields of prosthetics, telesurgery, and service and manufacturing robotics.Read moreRead less
The brain in real-time: predicting the present, reconstructing the past. This proposal aims to understand how the brain compensates for its own internal delays to function in real-time. Because it takes time for information from the senses to reach the brain, it takes time for us to become aware of an event that occurs in the outside world. This project will use an innovative combination of techniques to study how prediction and reconstruction mechanisms work together in the brain. Expected outc ....The brain in real-time: predicting the present, reconstructing the past. This proposal aims to understand how the brain compensates for its own internal delays to function in real-time. Because it takes time for information from the senses to reach the brain, it takes time for us to become aware of an event that occurs in the outside world. This project will use an innovative combination of techniques to study how prediction and reconstruction mechanisms work together in the brain. Expected outcomes of this project include a fundamental understanding of how we function in the present. This should provide significant benefits, such as an important theoretical advance in our understanding of how conscious awareness is realised in the brain, placing Australia at the cutting edge.Read moreRead less
Using toxins to understand the mechanisms of pain. Toxins have evolved in plants, animals and microbes as part of defensive and/or prey capture strategies, and have proven to be invaluable research tools as well as providing leads for potential new therapies. This project will use subtype-selective toxins to define the role of ion channels in pain, using novel pathway-specific and disease-specific animal models of pain. The findings from this project will provide significant insight into the ne ....Using toxins to understand the mechanisms of pain. Toxins have evolved in plants, animals and microbes as part of defensive and/or prey capture strategies, and have proven to be invaluable research tools as well as providing leads for potential new therapies. This project will use subtype-selective toxins to define the role of ion channels in pain, using novel pathway-specific and disease-specific animal models of pain. The findings from this project will provide significant insight into the neuropharmacology of pain, will lead to the identification of novel molecular targets with analgesic potential and is expected to provide novel treatment approaches for pain.Read moreRead less
Breathing disturbances and reflexes in sleep and effects on sleep and daytime function. This project will investigate protective reflexes in sleep and the impact of breathing disturbances and frequent arousal on markers of brain functioning and health. This will also significantly advance the understanding of key mechanisms promoting unstable breathing in sleep and ill health and functioning from disturbed sleep.