Assessment Of Novel Biomarkers That Are Related Neurobehavioural Dysfunction In Patients With Obstructive Sleep Anoea
Funder
National Health and Medical Research Council
Funding Amount
$312,941.00
Summary
Obstructive sleep apnea is recognised as a common condition that has a clearly measurable impact on public health. However it is often difficult for doctors to decide which patients have problems with driving or day to day brain functioning. This study will measure driving and memory during an extended period of waking in patients with sleep apnea. Special markers of brain function will be correlated with performance results during this extended wakefulness challenge.
Epidemiology Of Asthma And Lung Function In Australian Teenagers
Funder
National Health and Medical Research Council
Funding Amount
$292,639.00
Summary
Asthma is a major health issue, which cause long term illnesses. The causes of asthma are unclear. This is possibly because asthma is not just one condition, but multiple conditions, each with separate risk factors. This project will search for specific forms of asthma and their causes, using a group of children that has been intensively studied since birth.
Characterisation Of A Novel Signaling Network That Translates Early-life Respiratory Infection Into Chronic Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
Bacterial and viral respiratory infections in early-life cause permanent damage to the lungs and reduce lung function in later life. They may also increase the risk of developing asthma and emphysema. These are substantial health problems in Australia. My project aims to identify how infections cause these effects. This will enable me to identify new therapeutic targets and develop new therapies for the prevention of chronic lung diseases.
The Role Of Long Non-coding RNA In Regulating Lung Immunity And Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Chronic inflammatory diseases of the lung, asthma and COPD, account for significant morbidity and poor quality of life in our community. Respiratory infection is one of the major causes of exacerbation and affects 50-80% of both asthma and COPD patients admitted to hospital. These groups of patients are steroid resistance and difficult to manage. Our aim is to identify novel molecules important in regulating inflammation and to target them therapeutically to treat these patients.
Pregabalin And Speech Pathology Treatment For Refractory Chronic Cough With Laryngeal Hypersensitivity
Funder
National Health and Medical Research Council
Funding Amount
$155,747.00
Summary
Persistent cough that does not respond to medical treatment is debilitating and frustrating for the sufferer and very expensive for the Australian government. This research will provide a new and effective treatment option and extend our current reputation as the world leader in the identification and treatment of refractory chronic cough. This treatment strategy has not been trialled before and the findings will change current medical practice and significantly reduce community health costs.