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In-depth Association And Functional Studies Assessing The Role Of Novel Single Nucleotide Polymorphisms In PSA And Other Kallikrein Genes In Prostate Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$607,336.00
Summary
The number of men diagnosed with prostate cancer varies substantially between races, indicating a role of genetics in prostate cancer development. Recently, we demonstrated that the genetic variations in the PSA gene are related to prostate cancer risk. We aim to elucidate the molecular mechanism of this correlation and to systematically investigate the association of novel genetic variations in other PSA related genes with prostate cancer risk in a search of sensitive clinical biomarkers for pr ....The number of men diagnosed with prostate cancer varies substantially between races, indicating a role of genetics in prostate cancer development. Recently, we demonstrated that the genetic variations in the PSA gene are related to prostate cancer risk. We aim to elucidate the molecular mechanism of this correlation and to systematically investigate the association of novel genetic variations in other PSA related genes with prostate cancer risk in a search of sensitive clinical biomarkers for prostate cancer diagnosis and prognosis.Read moreRead less
Genetic Analysis Of De Novo And Inherited Exome Variation In Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$1,351,522.00
Summary
Schizophrenia (SCZ) is a severe mental disorder affecting ~1% of the world’s population. The majority of risk is explained by genetic factors, and thus identifying susceptibility genes may lead to the development of novel therapeutics and personalised treatments. We will join forces with international collaborators to perform the largest DNA sequencing analysis of de novo and inherited protein-coding sequence variation in SCZ to date. We aim to identify key risk genes and genetic pathways.
Investigating The Relationship Between Depression, Anxiety And Nausea And Vomiting During Pregnancy: Causation Or Shared Liability?
Funder
National Health and Medical Research Council
Funding Amount
$600,874.00
Summary
Recent studies showing women who experience severe Nausea and vomiting during pregnancy (NVP) have higher rates of Anxiety and Depression prior to pregnancy have revived earlier hypotheses that NVP may have a psychogenic component. We hypothesize that Anxiety and Depression do not play a causal role in NVP but rather, the relationship is due to shared risk from genetic effects that influence both traits. We will test this hypothesis using genetic and epidemiological approaches.
Solving the puzzle of complex disease - genes and their interactions with the environment. Many human diseases are caused by the interplay of genetic predisposition (nature) and the environment (nurture); but their causes remain a mystery, since much past research has focused on these aspects in isolation. This project will aim to better understand these complex diseases using a multi-factorial approach that brings both nature and nurture together.
Finding The Genetic Causes Of Asthma: The Australian Asthma Genetics Consortium (AAGC)
Funder
National Health and Medical Research Council
Funding Amount
$1,697,639.00
Summary
Asthma is a major burden on individuals and health systems. Despite many decades of research, no major effective new treatments for asthma have emerged recently. We will establish a large international consortium to systematically test nearly all known human genes to identify those that influence asthma susceptibility. We expect to identify pathways not previously implicated in asthma and so lead to a potential breakthrough in the development of more effective treatments.
Improving heat and drought tolerance in canola through genomic selection in Brassica rapa. This project aims to improve heat and drought tolerance in canola by identifying stress tolerance genes in the genetically diverse turnip family. An effective large-scale screening test for heat and drought tolerance will be developed and a number of heat- and drought-tolerant lines will be identified for genomic breeding and selection.
Healthy Heart, Healthy Brain - Using Genetic Data To Investigate The Causal Relationship Between Cardiovascular And Neurodegenerative Disease
Funder
National Health and Medical Research Council
Funding Amount
$191,261.00
Summary
There is growing evidence supporting a strong association between cardiovascular disease (CVD) with neurodegenerative disease. However, evidence from observational studies has been inconsistent. This project will use genetic data to investigate this link. The project outcomes may point to new avenues for research and prevention, whereby lifestyle modifications pharmaceutical interventions which decrease CVD might also hold promise for reducing the burden of neurodegenerative disease.
Exposing the complex and flexible genetic basis to polygenic adaptation: integrating population and quantitative genomic approaches. Using leading-edge genomic approaches, the project will dissect the genetic basis to adaptation across an entire species range. The results will highlight the complex nature of adaptation to environmental change and will deliver new approaches to study it in natural populations.
Discovery Early Career Researcher Award - Grant ID: DE210101407
Funder
Australian Research Council
Funding Amount
$447,524.00
Summary
Revealing and navigating a path to climate-ready crops. This project aims to investigate how well multi-dimensional biological and environmental data can be integrated to improve the prediction of plant performance under climatic fluctuations. This project expects to generate new knowledge in the area of quantitative genetics using an approach that combines trans-disciplinary research fields. Expected outcomes of this project include an example for how to advance conventional prediction methods ....Revealing and navigating a path to climate-ready crops. This project aims to investigate how well multi-dimensional biological and environmental data can be integrated to improve the prediction of plant performance under climatic fluctuations. This project expects to generate new knowledge in the area of quantitative genetics using an approach that combines trans-disciplinary research fields. Expected outcomes of this project include an example for how to advance conventional prediction methods using fundamental biological models that underlie plant growth. This will provide significant benefits, such as an enhancement of collaborative research across areas with the potential to significantly advance the general understanding of how plants interact with the environment.Read moreRead less
Genetic Analysis Of The Relationship Between Parental Age And Risk Of Psychiatric Disorders
Funder
National Health and Medical Research Council
Funding Amount
$301,012.00
Summary
Age-related de novo mutations are widely assumed to explain the association between advanced paternal age and risk of psychiatric illness, but this mechanism cannot explain the known risk to offspring of teenaged parents. We will investigate an alternative hypothesis for risk to children due to parental age, which is that elevated liability to mental illness, arising from shared genetic factors between parents and offspring, leads to delayed, or conversely teenage, parenthood.