From neuroscience to society: A multi-disciplinary study of human perception and cognition. This project aims to use a multi-disciplinary approach to investigate the factors influencing human perception and cognition - from the level of basic neuroscience, through to the wider impact felt by individuals and society when these functions are either impaired or enhanced. This will inform the basic research question of how the brain generates a conscious experience, identify the relationship between ....From neuroscience to society: A multi-disciplinary study of human perception and cognition. This project aims to use a multi-disciplinary approach to investigate the factors influencing human perception and cognition - from the level of basic neuroscience, through to the wider impact felt by individuals and society when these functions are either impaired or enhanced. This will inform the basic research question of how the brain generates a conscious experience, identify the relationship between altered visual cognitive function and clinical symptoms of psychosis, and determine the current prevalence and neuroethical issues associated with the non-medical use of drugs to enhance cognitive or perceptual function within Australia.Read moreRead less
How satiation control reward value and cue-induced appetitive behaviours. This proposal aims to identify mechanisms that control environment-driven food-seeking behaviours. It seeks to do so by using modern virally-mediated and basic behavioural as well as histological techniques in a transgenic rat to characterise novel hindbrain circuits that control these feeding behaviours. This is significant as environment-driven overeating is problematic yet underlying mechanisms are unclear. This project ....How satiation control reward value and cue-induced appetitive behaviours. This proposal aims to identify mechanisms that control environment-driven food-seeking behaviours. It seeks to do so by using modern virally-mediated and basic behavioural as well as histological techniques in a transgenic rat to characterise novel hindbrain circuits that control these feeding behaviours. This is significant as environment-driven overeating is problematic yet underlying mechanisms are unclear. This project expects to provide new knowledge on when, where and how hindbrain neurons control environment-driven food-seeking behaviours. This should provide benefits to the advancement of knowledge on the neural mechanisms of food-seeking and provide a basic science platform for future research on the study of feeding behaviours.
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A comprehensive framework for modelling the human connectome. The human brain is an extraordinarily complex network of interconnected cells. This project aims to use mathematical modelling and brain imaging to uncover key principles of network wiring in the human brain. Using an interdisciplinary approach that combines elements of neuroscience, genetics, physics, and psychology, the project will result in a new, rigorous framework for testing competing theories of brain development, the identifi ....A comprehensive framework for modelling the human connectome. The human brain is an extraordinarily complex network of interconnected cells. This project aims to use mathematical modelling and brain imaging to uncover key principles of network wiring in the human brain. Using an interdisciplinary approach that combines elements of neuroscience, genetics, physics, and psychology, the project will result in a new, rigorous framework for testing competing theories of brain development, the identification of key wiring principles for developing brains, and an understanding of how these principles shape behaviour. This work will shed new light on the developmental processes that underlie human behaviour and disease.Read moreRead less
The brain in real time: a neural model of rhythmic action and perception. This project aims to study a fundamental function of the human brain: its temporal architecture. It will provide an innovative perspective on the neural mechanisms underlying and relating perception, intention, and voluntary action in real time, though a combination of eye-tracking, behaviour, and neural recordings. By providing a common language with which to relate perception, cognition, volition and action, this will ....The brain in real time: a neural model of rhythmic action and perception. This project aims to study a fundamental function of the human brain: its temporal architecture. It will provide an innovative perspective on the neural mechanisms underlying and relating perception, intention, and voluntary action in real time, though a combination of eye-tracking, behaviour, and neural recordings. By providing a common language with which to relate perception, cognition, volition and action, this will provide significant benefits that will transform the way we think about brain function.Read moreRead less
Chronic pain and functional impairment following traumatic injury: an investigation into the impact of compensation status and experience. This project will enhance understanding of the impact of the psychosocial factors and the compensation process on recovery from traumatic injury. The project will generate new resources (screening and referral guidelines; educational materials) to improve decision making consistency, client experience, and recovery from road trauma.
Discovery Early Career Researcher Award - Grant ID: DE140100588
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Gene-environment interactions in the regulation of neuroplasticity and cognitive function . This project will study the effects of different housing conditions on neuroplasticity-related cognitive function by combining an innovative operant conditioning behavioural test (computerised touch-screen technology) and new molecular approaches. Potential gene-environment interactions will be revealed using genetically targeted mice which have never been assessed in that context (mutants with altered gl ....Gene-environment interactions in the regulation of neuroplasticity and cognitive function . This project will study the effects of different housing conditions on neuroplasticity-related cognitive function by combining an innovative operant conditioning behavioural test (computerised touch-screen technology) and new molecular approaches. Potential gene-environment interactions will be revealed using genetically targeted mice which have never been assessed in that context (mutants with altered glucocorticoid and serotonin signalling). This project will study whether specific stages of the neuroplasticity process are differentially modulated through gene-environment interactions, ultimately resulting in changes to behaviour and cognitive functions. This will lead to a better understanding of the potential approaches that could be used to improve cognitive function.Read moreRead less
Learning from errors: examining the neural mechanisms underlying performance monitoring and adaptive behaviour. This project aims to contribute to current scientific thinking on how the brain mechanisms underlying error processing influence adaptive behaviour. Self-recognition of errors deteriorates in many clinical conditions and is a predictor of poor prognostic outcome. However, it remains unclear how such dysfunction leads to the failure to adapt behaviour.
Discovery Early Career Researcher Award - Grant ID: DE140100750
Funder
Australian Research Council
Funding Amount
$395,106.00
Summary
Associative learning and fluid intelligence: Computational and neurogenetic analyses. This project investigates genetic contributions to associative learning, one of our most fundamental abilities. Associative learning allows us to navigate in our environment, predict future events and make appropriate decisions. Electrophysiological measures will be used to study learning processes precisely and to investigate their relationship to polymorphisms in genes that regulate neural function. This rese ....Associative learning and fluid intelligence: Computational and neurogenetic analyses. This project investigates genetic contributions to associative learning, one of our most fundamental abilities. Associative learning allows us to navigate in our environment, predict future events and make appropriate decisions. Electrophysiological measures will be used to study learning processes precisely and to investigate their relationship to polymorphisms in genes that regulate neural function. This research will further understanding of the mechanisms that generate individual differences in learning ability and will have applications for educational techniques and behavioural interventions.Read moreRead less
Mapping and manipulating fear prediction errors. This project plans to use Pavlovian conditioning to map and then manipulate the brain architecture of fear prediction errors. It asks fundamental questions about how Pavlovian conditioning and associative learning enable us to learn to fear, to reduce fear, and to respond appropriately to danger. It aims to answer these questions with behavioural sophistication and previously unobtainable cell-type, temporal, and circuit-level precision. It aims t ....Mapping and manipulating fear prediction errors. This project plans to use Pavlovian conditioning to map and then manipulate the brain architecture of fear prediction errors. It asks fundamental questions about how Pavlovian conditioning and associative learning enable us to learn to fear, to reduce fear, and to respond appropriately to danger. It aims to answer these questions with behavioural sophistication and previously unobtainable cell-type, temporal, and circuit-level precision. It aims to provide new insights into the mechanisms of Pavlovian conditioning, associative learning, and emotion: insights that are necessary to shape the next generation of theoretical accounts and practical applications.Read moreRead less
PET imaging of learning-related plasticity in awake behaving rats. The objective of the project is to combine an investigation of basic learning paradigms with functional Positron emission tomography (PET) imaging in rats in order to answer critical questions about the neurobiological basis of learning and decision-making in the brain. MicroPET technology provides PET images without the confounds induced by anaesthesia. Using this technology, the project intends to observe whole-brain changes in ....PET imaging of learning-related plasticity in awake behaving rats. The objective of the project is to combine an investigation of basic learning paradigms with functional Positron emission tomography (PET) imaging in rats in order to answer critical questions about the neurobiological basis of learning and decision-making in the brain. MicroPET technology provides PET images without the confounds induced by anaesthesia. Using this technology, the project intends to observe whole-brain changes in dopamine neurotransmission in awake, behaving rats while they learn to predict motivationally relevant outcomes based on environmental cues and on their own actions (ie during Pavlovian and instrumental conditioning, respectively). The outcomes of this research may improve our understanding of the neural changes responsible for debilitating disorders of the brain and mind.Read moreRead less