Discovery Early Career Researcher Award - Grant ID: DE130100463
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Back to the future - dissociating mental simulation processes in the brain. Remembering the past and imagining the future are two linked processes that rely on a core brain network. The project will examine how damage to different parts of this brain network affects mental simulation of the past and future, providing fundamental information regarding the role of brain structures and systems for complex thought processes.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100055
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
State-of-the-art upgrade to multi-transmit multi-receive technology for research dedicated 3 Tesla magnetic resonance imaging (MRI) scanner. Projects requiring the proposed infrastructure are aligned with two National Research Priorities. The research will lead to new methods for imaging and detecting soft tissue changes, identifying developmental, cognitive and degenerative disorders, and pharmacological research. The understanding of the basis of physiological, cognitive and biochemical proces ....State-of-the-art upgrade to multi-transmit multi-receive technology for research dedicated 3 Tesla magnetic resonance imaging (MRI) scanner. Projects requiring the proposed infrastructure are aligned with two National Research Priorities. The research will lead to new methods for imaging and detecting soft tissue changes, identifying developmental, cognitive and degenerative disorders, and pharmacological research. The understanding of the basis of physiological, cognitive and biochemical processes which will be facilitated by the new equipment will contribute to the priority area Promoting and Maintaining Good Health and will underpin an array of subsequent medical research. The new equipment will extend capabilities and training in signal analysis, biomedical engineering and biomedicine, contributing to the priority area Frontier technologies for Building and Transforming Australian Industries.Read moreRead less
Brain mechanisms for coordinating with others through sound. Distinguishing between sounds produced by self and others is critical for interpersonal coordination and communication through speech and music. This project employs a novel dual-brain electrophysiological technique with tagged audio signals to elucidate how the human brain achieves this distinction, and when and why it cannot. Expected outcomes include new knowledge on the neurophysiological mechanisms that support self-other processi ....Brain mechanisms for coordinating with others through sound. Distinguishing between sounds produced by self and others is critical for interpersonal coordination and communication through speech and music. This project employs a novel dual-brain electrophysiological technique with tagged audio signals to elucidate how the human brain achieves this distinction, and when and why it cannot. Expected outcomes include new knowledge on the neurophysiological mechanisms that support self-other processing, and the acoustic conditions and behavioural strategies that facilitate their operation. These outcomes should ultimately have applied benefits for improving interpersonal coordination and social interaction, especially in digital environments and clinical populations with atypical self-other processing.Read moreRead less
Modelling and manipulating brain network dynamics across the lifespan. This project aims to integrate advanced computational modelling and state-of-the-art recording techniques to generate new knowledge on the neural basis of ageing. People are said to grow wiser as they grow older, though more likely they will experience cognitive slowing and reduced memory functions that interfere with their daily lives. The anticipated goal of the project is to develop techniques to predict the personalised e ....Modelling and manipulating brain network dynamics across the lifespan. This project aims to integrate advanced computational modelling and state-of-the-art recording techniques to generate new knowledge on the neural basis of ageing. People are said to grow wiser as they grow older, though more likely they will experience cognitive slowing and reduced memory functions that interfere with their daily lives. The anticipated goal of the project is to develop techniques to predict the personalised effects of brain stimulation on the ageing brain. The outcomes of this research could significantly improve understanding of brain ageing, and advance the fields of systems neuroscience, network science, and brain stimulation.Read moreRead less
Cannabis and the brain: the good, the bad and the unknown. Cannabis is the most widely used illicit drug but much remains unknown about how it affects the brain. This research will examine effects on brain cells through to whole brain function in humans to determine how cannabis use may lead to impaired thinking or psychological symptoms and why cannabis might affect individuals in different ways.
Understanding biological pathways underlying social behaviour in humans. This project aims to show for the first time how oxytocin interacts with neural social and reward pathways to guide social behaviour. Oxytocin is a natural neuropeptide and hormone that has a critical role in the regulation of social behaviour across mammalian species. In animals, direct evidence demonstrates how endogenous and exogenous oxytocin interacts with social and reward neural pathways to alter social behaviour, in ....Understanding biological pathways underlying social behaviour in humans. This project aims to show for the first time how oxytocin interacts with neural social and reward pathways to guide social behaviour. Oxytocin is a natural neuropeptide and hormone that has a critical role in the regulation of social behaviour across mammalian species. In animals, direct evidence demonstrates how endogenous and exogenous oxytocin interacts with social and reward neural pathways to alter social behaviour, including social recognition, relationship formation, and long-term bonds. The project intends to use radio-labelling techniques in combination with positron emission tomography to track oxytocin and show what regions of the brain oxytocin impacts to then influence social cognition and behaviour in humans.Read moreRead less
Fundamental neurocognitive mechanisms underpinning creative thought. The project aims to understand the neural and cognitive bases of creative thought by using a novel approach and recent framework that has emerged from the study of semantic cognition and executive control functions. Creative thought is fundamental to human advances throughout history and it is the foundation to all arts and sciences. Expected outcomes are a framework that can explain the source of knowledge and the evaluative ....Fundamental neurocognitive mechanisms underpinning creative thought. The project aims to understand the neural and cognitive bases of creative thought by using a novel approach and recent framework that has emerged from the study of semantic cognition and executive control functions. Creative thought is fundamental to human advances throughout history and it is the foundation to all arts and sciences. Expected outcomes are a framework that can explain the source of knowledge and the evaluative mechanisms needed to generate new and useful ideas. Significant benefits will be to advance our understanding of the neurocognitive mechanisms of creative thought, which can enhance Australia’s scientific capability through training and collaboration and broader society by enhancing capacity for innovative thinking. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101064
Funder
Australian Research Council
Funding Amount
$373,536.00
Summary
How musical rhythms entrain the human brain. This project is designed to investigate the brain mechanisms that allow humans to feel the beat in musical rhythms. Although such activity facilitates pro-social and therapeutic effects, the underlying brain mechanisms remain unknown. The project intends to examine the interface between musical rhythms, behaviour and brain activity to increase knowledge on a fundamental process of brain function: the dynamic coupling between perception and body moveme ....How musical rhythms entrain the human brain. This project is designed to investigate the brain mechanisms that allow humans to feel the beat in musical rhythms. Although such activity facilitates pro-social and therapeutic effects, the underlying brain mechanisms remain unknown. The project intends to examine the interface between musical rhythms, behaviour and brain activity to increase knowledge on a fundamental process of brain function: the dynamic coupling between perception and body movement. The project aims to provide insight into how psychological, environmental and neural mechanisms affect entrainment to rhythmic events and inform practices for education and clinical rehabilitation.Read moreRead less
Multimodal testing for a fast subcortical route for salient visual stimuli. This project aims to uncover links between underlying brain circuitry, uncertainty and consciousness, and perceptions of fear. The project will use a multi-modal combination of brain imaging and neural recording techniques to generate new knowledge about the brain’s processing of biologically relevant information. The expected outcomes will enhance our knowledge of how the brain rapidly and non-consciously prepares the ....Multimodal testing for a fast subcortical route for salient visual stimuli. This project aims to uncover links between underlying brain circuitry, uncertainty and consciousness, and perceptions of fear. The project will use a multi-modal combination of brain imaging and neural recording techniques to generate new knowledge about the brain’s processing of biologically relevant information. The expected outcomes will enhance our knowledge of how the brain rapidly and non-consciously prepares the body for potential escape behaviours and of the brain pathways engaged in fear perception. The outcomes have the potential to inform strategies for overcoming anxiety and its effects on daily life, social interactions and workplace productivity.Read moreRead less
What is the functional significance of mirror neurons? Contrasting the adaptation and association models of the mirror neuron system. Mirror neurons are a type of brain cell that are thought to underlie empathy and cause autism. Alternatively, however, mirror neurons might instead arise from repeated associations between what we see and what we do. This study uses brain stimulation and neuroimaging techniques to determine the function of mirror neurons.