Identifying Malingered Posttraumatic Stress Disorder: Biological Markers for Legal Assessment. Posttraumatic stress disorder (PTSD) is the most common psychiatric disorder that is claimed in compensation claims in Australia. There are currently no reliable means to distinguish malingered from genuine PTSD. This project aims to develop the most accurate means of identifying malingered PTSD by using the most recent technology to index biological responses, including fMRI, in participants with PT ....Identifying Malingered Posttraumatic Stress Disorder: Biological Markers for Legal Assessment. Posttraumatic stress disorder (PTSD) is the most common psychiatric disorder that is claimed in compensation claims in Australia. There are currently no reliable means to distinguish malingered from genuine PTSD. This project aims to develop the most accurate means of identifying malingered PTSD by using the most recent technology to index biological responses, including fMRI, in participants with PTSD, without PTSD, and malingered PTSD. This study will lead to a biological assessment that can objectively index PTSD and be resistant to intentional feigning. These data will significantly enhance legal assessments of PTSD and facilitate compensation resolution.Read moreRead less
Special Research Initiatives - Grant ID: SR0354823
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
National network for the study of cognitive processes and treatment across the phases of schizophrenia. Schizophrenia is associated with great costs to the community and individual. Controlled studies have demonstrated Cognitive Behaviour Therapy (CBT) is efficacious in treating symptoms of schizophrenia. Studies of cognitive processes have also advanced understanding of psychotic phenomena. This initiative affords the opportunity to
1) Improve treatment efficacy by developing, testing and appl ....National network for the study of cognitive processes and treatment across the phases of schizophrenia. Schizophrenia is associated with great costs to the community and individual. Controlled studies have demonstrated Cognitive Behaviour Therapy (CBT) is efficacious in treating symptoms of schizophrenia. Studies of cognitive processes have also advanced understanding of psychotic phenomena. This initiative affords the opportunity to
1) Improve treatment efficacy by developing, testing and applying theoretically-driven models of psychotic symptoms.
2) Disseminate the findings of research on CBT for psychotic disorders in clinical settings by (a) training the work-force, and (b) facilitating CBT delivery in routine practice.
3) Apply CBT in various settings with a variety of psychotic populations to test its effectiveness in routine clinical settings.
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Models of adolescent drug use and its consequences. Recent concerns surround the impact of drug abuse - particularly binge drinking, inhalant abuse and cannabis use - on the mental health of adolescents. Early drug use is associated with mental health problems although the mechanisms involved are not well characterised. The present proposal aims to use animal models to characterise substance abuse that occurs during the adolescent period and to investigate its effects on brain and behaviour. Inc ....Models of adolescent drug use and its consequences. Recent concerns surround the impact of drug abuse - particularly binge drinking, inhalant abuse and cannabis use - on the mental health of adolescents. Early drug use is associated with mental health problems although the mechanisms involved are not well characterised. The present proposal aims to use animal models to characterise substance abuse that occurs during the adolescent period and to investigate its effects on brain and behaviour. Increasing our knowledge of the causes and consequences of adolescent drug abuse will improve Australia's ability to confront this problem and to develop early interventions and treatments that minimise associated harms.Read moreRead less
Imaging genetics in schizophrenia and bipolar disorder: shared neurocognitive endophenotypes. Combined, schizophrenia and bipolar disorder afflict approximately 506,000 Australians at any one time, and are leading causes of disability and national economic burden. This study will delineate genetic underpinnings for these conditions in association with specific neurocognitive dysfunctions that are common to both disorders. These findings have important implications for the implementation of perso ....Imaging genetics in schizophrenia and bipolar disorder: shared neurocognitive endophenotypes. Combined, schizophrenia and bipolar disorder afflict approximately 506,000 Australians at any one time, and are leading causes of disability and national economic burden. This study will delineate genetic underpinnings for these conditions in association with specific neurocognitive dysfunctions that are common to both disorders. These findings have important implications for the implementation of personalised pharmaceutical treatments on the basis of genotype, and the development of therapeutic agents to target cognitive function. These results will also aid detection of premorbid psychotic illness in young individuals who may benefit from early intervention that may thwart the illness trajectory. Read moreRead less
A philosophical and empirical approach to the nature of perception and belief. This project offers substantial benefits - intellectual, practical, and ultimately economic - to the nation. On the intellectual side, the project will contribute to research output and will further enhance the national research strength in the study of delusions, rationality, and agency, within both philosophy of mind and inter-disciplinary cognitive science. On the practical side, the project offers the prospect of ....A philosophical and empirical approach to the nature of perception and belief. This project offers substantial benefits - intellectual, practical, and ultimately economic - to the nation. On the intellectual side, the project will contribute to research output and will further enhance the national research strength in the study of delusions, rationality, and agency, within both philosophy of mind and inter-disciplinary cognitive science. On the practical side, the project offers the prospect of considerable benefits for the community as improved theories of the nature and causes of delusions generate strategies for earlier detection or even prevention of the development of delusions, new methods of therapy for patients, and better understanding for families.Read moreRead less
Enhancing Mental Health in Aboriginal Children. The poor health, academic, and mental health functioning of Aboriginal children is one of Australia's major public health problems. This project will identify the specific factors that lead to these problems and empirically evaluate management programs aimed at leading to reduced violence and better mental health. This program aims to interupt the intergenerational cycle of violence and mental health problems in Australian Aborigines.
Preventing Suicide: A psychological autopsy study of the last contact with a health professional before suicide. In Australia, 48% of all suicides in 2000 were by 35-64 year olds; an additional 13% were by 65 years and over. This study will examine the last clinical contact older suicide victims had with health professionals in order to determine whether this contact offers an opportunity for intervention. For the first time in Australia, GP's, health professionals, and the deceased's next-of-ki ....Preventing Suicide: A psychological autopsy study of the last contact with a health professional before suicide. In Australia, 48% of all suicides in 2000 were by 35-64 year olds; an additional 13% were by 65 years and over. This study will examine the last clinical contact older suicide victims had with health professionals in order to determine whether this contact offers an opportunity for intervention. For the first time in Australia, GP's, health professionals, and the deceased's next-of-kin will be interviewed to determine the context surrounding the deceased's death, and the abilities of health professionals to identify warning signs and to intervene prior to suicide. Given our ageing population, the outcomes will be significant in educating all health professionals to identify suicidal signs, and to prevent premature death in the elderly.Read moreRead less
Normal and abnormal processes of social attention orienting. Human beings are capable of rapidly detecting the direction of another person's eye-gaze and shifting attention reflexively in that direction. This project will compare shifts of attention to non-social and social cues of direction to determine whether attentional shifts to gaze-direction are fast because humans are biologically hard-wired to respond to social cues of evolutionary significance (eyes) or because humans are well-practice ....Normal and abnormal processes of social attention orienting. Human beings are capable of rapidly detecting the direction of another person's eye-gaze and shifting attention reflexively in that direction. This project will compare shifts of attention to non-social and social cues of direction to determine whether attentional shifts to gaze-direction are fast because humans are biologically hard-wired to respond to social cues of evolutionary significance (eyes) or because humans are well-practiced at using a number of different signals for direction in their environment. Findings from this work will than be used to investigate whether a selective impairment of responding to gaze-direction contributes to the social impairments so characteristic of people with schizophrenia.
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Australian Laureate Fellowships - Grant ID: FL0992334
Funder
Australian Research Council
Funding Amount
$2,321,000.00
Summary
An Empirical Model of Aboriginal Mental Health. The poor health, academic, and mental health functioning of Aboriginal children is one of Australia's major public health problems. This project will identify the specific factors that lead to these problems and provide an evidence base to shape future empirically-informed interventions to reduce violence and mental health problems in Aboriginal communities. This project directly addresses the National Research Priority of Strengthening Australia ....An Empirical Model of Aboriginal Mental Health. The poor health, academic, and mental health functioning of Aboriginal children is one of Australia's major public health problems. This project will identify the specific factors that lead to these problems and provide an evidence base to shape future empirically-informed interventions to reduce violence and mental health problems in Aboriginal communities. This project directly addresses the National Research Priority of Strengthening Australia's Social and Economic Fabric and a Healthy Start to Life by establishing the empirical platform to shape future policies for enhancing the mental health of Aboriginal youth.Read moreRead less
THE NATURAL HISTORY OF COGNITIVE IMPAIRMENT AND DEMENTIA IN A STROKE COHORT
Funder
National Health and Medical Research Council
Funding Amount
$290,747.00
Summary
In a current NHMRC-funded study, we have examined 200 stroke patients (and 100 control subjects) at 3 months after a stroke and one year later, and identified those who have impairment in memory and other cognitive functions. We have also studied these subjects in detail from a psychiatric perspective and performed brain scans on them using magentic resonance imaging. We find that many stroke patients have problems with their cognitive functioning which has a major impact on their lives. A large ....In a current NHMRC-funded study, we have examined 200 stroke patients (and 100 control subjects) at 3 months after a stroke and one year later, and identified those who have impairment in memory and other cognitive functions. We have also studied these subjects in detail from a psychiatric perspective and performed brain scans on them using magentic resonance imaging. We find that many stroke patients have problems with their cognitive functioning which has a major impact on their lives. A large number also become depressed. These consequences of stroke are not given sufficient importance by clinicians. The fact that stroke is a common problem in the elderly, and our society is aging, makes this a problem of major public health significance. In the new proposal, we plan to study these subjects up to 3 years with repeat neuropsychiatric assessments and brain scans to investigate the natural history of stroke-related cognitive impairment. We will determine whether further new cases of dementia develop in the period 1-3 years, what happens to the brain lesions picked up on brain scans, and how these deficiencies affect the patients' living status and their longevity. We will be able to determine the factors that lead to a good outcome, and suggest strategies that may be applicable to improve the functioning of these individuals.Read moreRead less