Discovery Early Career Researcher Award - Grant ID: DE230100356
Funder
Australian Research Council
Funding Amount
$450,241.00
Summary
Bacterial membrane remodelling and the interaction with peptides. This project aims to elucidate the fundamental mechanism of lipid remodelling in Gram-negative outer membrane, which is critical both in preventing noxious compounds and evading host immune defence. For the first time, the complex interplays between bacterial cellular metabolism and membrane remodelling will be defined through systems pharmacology, and the precise membrane-peptide interaction will be examined by computational and ....Bacterial membrane remodelling and the interaction with peptides. This project aims to elucidate the fundamental mechanism of lipid remodelling in Gram-negative outer membrane, which is critical both in preventing noxious compounds and evading host immune defence. For the first time, the complex interplays between bacterial cellular metabolism and membrane remodelling will be defined through systems pharmacology, and the precise membrane-peptide interaction will be examined by computational and biophysical approaches. Novel knowledge will be generated to improve our understanding on how bacteria remodel their outer membrane in response to environmental stress. This will benefit the future design of much-needed antimicrobial strategies including products and technologies to target bacterial membrane. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100301
Funder
Australian Research Council
Funding Amount
$440,000.00
Summary
Reducing uncertainty in prediction of leaf respiration in a changing world. This project aims to advance our understanding of responses of carbon dioxide (CO2) release by leaf (leaf respiration) to sustained changes in CO2 and temperature. Leaf respiration in terrestrial forests releases yearly CO2 that is two to four times higher than CO2 emitted by human activities, but its response to climate change is not well understood. The project expects to generate new knowledge on mechanisms underlying ....Reducing uncertainty in prediction of leaf respiration in a changing world. This project aims to advance our understanding of responses of carbon dioxide (CO2) release by leaf (leaf respiration) to sustained changes in CO2 and temperature. Leaf respiration in terrestrial forests releases yearly CO2 that is two to four times higher than CO2 emitted by human activities, but its response to climate change is not well understood. The project expects to generate new knowledge on mechanisms underlying responses of leaf respiration to these climate change variables, separately and combined. Expected outcome is to deliver criteria that enable dynamic changes in leaf respiration to be predicted in climate models. Results should benefit improved forecast of feedback between Australian forests' carbon cycling and climate.Read moreRead less
Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying ....Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying regulators of lipid metabolism. The large diversity in humans necessitate sufficient sample sizes to identify true genetic regulators, but to date techniques capturing phenotypic data (lipids) have been largely limited. It is anticipated that this study will identify new regulators of lipid metabolism in humans.Read moreRead less
HoliCOW - A holobiont strategy to uncover the core microbiome in cows. Human population growth is driving a rise in cattle production for food, which necessitates sustainable practices that simultaneously optimise animal nutrition while reducing methane emissions, a critical greenhouse gas. This project aims to unravel and exploit biological connections across the cow holobiont, which pertains to the feed cows eat, their bodily function and the microbes in their rumen. This project will leverage ....HoliCOW - A holobiont strategy to uncover the core microbiome in cows. Human population growth is driving a rise in cattle production for food, which necessitates sustainable practices that simultaneously optimise animal nutrition while reducing methane emissions, a critical greenhouse gas. This project aims to unravel and exploit biological connections across the cow holobiont, which pertains to the feed cows eat, their bodily function and the microbes in their rumen. This project will leverage multi-layered molecular data derived from the cow holobiont to identify, characterise and ultimately control the core rumen microbiome that causes methane production in animals. The outcome will be new knowledge to facilitate microbiome-based interventions that benefit animal production and reduce its carbon footprint.Read moreRead less
Cellular Ageing: Is the Plasma Membrane the Control Hub? This project aims to determine whether the plasma membrane lipid composition is a major driver of cellular ageing. It expects to generate new knowledge in the molecular mechanism of cellular ageing, utilising our team’s deep expertise in lipid biology, bioinformatics, biophysics, extracellular vesicle biology and cellular ageing. Expected outcomes include the identification of novel cellular ageing markers and anti-ageing targets while als ....Cellular Ageing: Is the Plasma Membrane the Control Hub? This project aims to determine whether the plasma membrane lipid composition is a major driver of cellular ageing. It expects to generate new knowledge in the molecular mechanism of cellular ageing, utilising our team’s deep expertise in lipid biology, bioinformatics, biophysics, extracellular vesicle biology and cellular ageing. Expected outcomes include the identification of novel cellular ageing markers and anti-ageing targets while also cementing long-standing partnerships and fostering new interdisciplinary collaborations. This cellular ageing study will provide novel insights into the basic principles of cellular behaviour, e.g. growth, differentiation, communication and death, reinforcing Australia’s leadership in biological science.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100317
Funder
Australian Research Council
Funding Amount
$459,562.00
Summary
Single-cell metabolite imaging of the coral-microalgal symbiosis. Corals sustain some of the most diverse ecosystems on Earth but are at risk due to warming and acidifying oceans. Coral survival critically depends on the photosynthetic microalgae that live inside the coral and provide the coral with nutrients. Many aspects of this coral-algal relationship remain poorly defined. This project aims to unravel coral-algal interactions with single-cell imaging. Insights from extreme environment coral ....Single-cell metabolite imaging of the coral-microalgal symbiosis. Corals sustain some of the most diverse ecosystems on Earth but are at risk due to warming and acidifying oceans. Coral survival critically depends on the photosynthetic microalgae that live inside the coral and provide the coral with nutrients. Many aspects of this coral-algal relationship remain poorly defined. This project aims to unravel coral-algal interactions with single-cell imaging. Insights from extreme environment corals will reveal how these microalgae may facilitate coral survival under future climate change, providing vital information for reef managers and restoration practitioners. By establishing a novel method, databases and networks, this project will create a powerful forward momentum for coral-algal research.Read moreRead less