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Discovery Early Career Researcher Award - Grant ID: DE150101196
Funder
Australian Research Council
Funding Amount
$403,536.00
Summary
Elucidation and characterisation of the misfolded protein interactome. Correct expression, folding, and clearance of proteins are critical for all cell functions. However, cell stresses and aging can cause protein balance mechanisms to become overloaded, resulting in the misfolding and aggregation of proteins. Understanding the mechanisms by which protein aggregation occurs and how to prevent the process have become major scientific challenges. This project aims to gain unprecedented insights in ....Elucidation and characterisation of the misfolded protein interactome. Correct expression, folding, and clearance of proteins are critical for all cell functions. However, cell stresses and aging can cause protein balance mechanisms to become overloaded, resulting in the misfolding and aggregation of proteins. Understanding the mechanisms by which protein aggregation occurs and how to prevent the process have become major scientific challenges. This project aims to gain unprecedented insights into the interactors, effectors and fate of misfolded protein aggregates within cells, using new, cutting-edge, catalytic-tagging biochemical tools. Critical interactions will be investigated for their roles in protein aggregation cell death, and in whether modulation of the interaction can also mitigate or reverse the process.Read moreRead less
Molecular insights into bacterial metal ion homeostasis and toxicity. This project aims to measure bacterial cellular metal concentrations, elucidate mechanisms cells use to adapt to changing extracellular metal concentrations, and reveal the molecular targets of metal toxicity. Metal ions are essential to all forms of life, and half of all proteins use metal ions for cellular chemical processes. However, how cells precisely balance sufficient metal ions for essential cellular chemistry without ....Molecular insights into bacterial metal ion homeostasis and toxicity. This project aims to measure bacterial cellular metal concentrations, elucidate mechanisms cells use to adapt to changing extracellular metal concentrations, and reveal the molecular targets of metal toxicity. Metal ions are essential to all forms of life, and half of all proteins use metal ions for cellular chemical processes. However, how cells precisely balance sufficient metal ions for essential cellular chemistry without accumulating a toxic excess (metal homeostasis) is poorly understood. Discovering the roles of metal ions in bacterial cells will be key to defining the chemical biology of living systems and will provide information essential to understanding how microbes adapt to changing environments.Read moreRead less
Decision-making modules in protein interaction networks. This project aims to discover how cells use proteins to make decisions. This is important for all living things, which must react to stimuli to grow, adapt, defend themselves and to die. The project’s anticipated outcome is the systems-level identification of decision-making modules in an intracellular network. Its focus is on the smallest possible modules, which contain a decision-making protein with two modifications that control protein ....Decision-making modules in protein interaction networks. This project aims to discover how cells use proteins to make decisions. This is important for all living things, which must react to stimuli to grow, adapt, defend themselves and to die. The project’s anticipated outcome is the systems-level identification of decision-making modules in an intracellular network. Its focus is on the smallest possible modules, which contain a decision-making protein with two modifications that control protein-proteins interactions. It will investigate two recurrent decision-making modules. The expected benefits of the project include new means to decipher biological complexity, and targets to modulate biosystems by genome editing or with drugs.Read moreRead less
The protein O-glycosylation pathway of Neisseria: a model system for O-glycosylation of bacterial proteins with potential use in biotechnology. Proteins can be modified by the addition of sugar molecules. This process, called glycosylation, has been studied for some time in humans and other higher organisms, but is relatively new in the field of bacteria. This study will use the bacterium Neisseria as a model system for this process and work to harness the system for use in biotechnology.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100096
Funder
Australian Research Council
Funding Amount
$235,000.00
Summary
Advanced high resolution mass spectrometer for collaborative proteomic and lipidomics research. The equipment will make possible targeted research for the comprehensive high sensitivity analysis of proteins and lipids. Permitting a unique understanding of how these molecules interact within normal or diseased cells and other samples.
The role and regulation of protein methylation: a study using the recently developed methylation network of yeast. Tiny changes to proteins, such as methylation, can alter the way they interact with other proteins. This project will investigate the dynamics of protein methylation during the life of the yeast cell. The project results will be of long term relevance to situations where we may want to stop cells dividing, such as cancer or infectious disease.
Discovery Early Career Researcher Award - Grant ID: DE120100390
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Characterisation of collagenous lectins and their roles in ovine infectious diseases. Specific proteins involved in immunity against infections will be studied in sheep to enhance their immune response against specific infections, such as ovine Johne's disease and footrot. This may lead to selective breeding of sheep that are more resistant to disease, minimising production losses and use of medications.
Structural analysis of a novel plasma membrane coat complex. The plasma membrane of mammalian cells forms a crucial barrier between the cell and the outside world. This project investigates how a newly-discovered family of proteins work together to generate specialised regions of the plasma membrane called caveolae.
Untangling the plant Golgi apparatus: Functional proteomics to understand plant cell wall biosynthesis. The plant cell wall determines plant morphology and structure. It is also a major factor in food quality, and it is used as forage and is the raw material for a range of industries. A significant proportion of the cell wall is synthesised in a poorly studied cellular compartment known as the Golgi apparatus. This project intends to exploit unique isolation and analytical techniques in conjunct ....Untangling the plant Golgi apparatus: Functional proteomics to understand plant cell wall biosynthesis. The plant cell wall determines plant morphology and structure. It is also a major factor in food quality, and it is used as forage and is the raw material for a range of industries. A significant proportion of the cell wall is synthesised in a poorly studied cellular compartment known as the Golgi apparatus. This project intends to exploit unique isolation and analytical techniques in conjunction to further profile and characterise this structure in order to uncover new information about the complex interplay of components involved in plant cell wall biosynthesis. This information will be used to support approaches to manipulate cell walls to produce plant biomass optimised for agricultural and industrial applications.Read moreRead less
Activation of invasion in Toxoplasma. Host cell invasion is critical for the establishment and maintenance of infection by the single-celled parasite Toxoplasma gondii, the causative agent of Toxoplasmosis. This project will use the latest molecular techniques to understand how invasion is activated and will define a new set of drug targets to treat Toxoplasmosis and related diseases.