Discovery Early Career Researcher Award - Grant ID: DE210101666
Funder
Australian Research Council
Funding Amount
$395,588.00
Summary
Engineering nanoparticles with enhanced adhesion at the nano-bio interfaces. This project aims to develop a next-generation adhesive nanoparticle platform through in-depth understandings of nanoparticle interactions with bio-interfaces. This project expects to generate new knowledge in the multidisciplinary research field at nano-bio-interfaces by using a recently developed nano-colloidal probe technology, instructing the rational design of nanoparticles with enhanced interface adhesive properti ....Engineering nanoparticles with enhanced adhesion at the nano-bio interfaces. This project aims to develop a next-generation adhesive nanoparticle platform through in-depth understandings of nanoparticle interactions with bio-interfaces. This project expects to generate new knowledge in the multidisciplinary research field at nano-bio-interfaces by using a recently developed nano-colloidal probe technology, instructing the rational design of nanoparticles with enhanced interface adhesive properties. Expected outcomes include a family of adhesive nanoparticles designed for nanopesticide and animal feed applications, with the potential to deliver valuable intellectual property of commercial interest and economic benefit through technology advancement.Read moreRead less
Design a Targeted Delivery System for Probiotics. The project aims to improve the effectiveness of probiotics by developing a targeted delivery system to the colon. This interdisciplinary research will generate new knowledge in the field of microbiota and develop new delivery systems for live microorganisms and other active compounds. Expected outcomes include increased understanding of the factors affecting the viability of probiotics during storage and passage through the gastro-intestinal tra ....Design a Targeted Delivery System for Probiotics. The project aims to improve the effectiveness of probiotics by developing a targeted delivery system to the colon. This interdisciplinary research will generate new knowledge in the field of microbiota and develop new delivery systems for live microorganisms and other active compounds. Expected outcomes include increased understanding of the factors affecting the viability of probiotics during storage and passage through the gastro-intestinal tract, the establishment of probiotics into gut flora, and how this incorporation affects the dynamics of gut microbiota. The new technology can be utilised across a wide range of therapeutics that target the colon to promote the well-being of our society through commercialisation by industry partner.Read moreRead less
Unravelling the mechanics of particle deposition at the micro-scale. This project aims to discover the mechanisms responsible for the interactions between aerosol particles and surfaces in a range of air flow conditions. The project expects to transform our understanding of particle deposition through a combination of novel laser-based diagnostic techniques, optical coherence tomography, and state of the art particle formulation methodologies. Expected outcomes of the project include delivery of ....Unravelling the mechanics of particle deposition at the micro-scale. This project aims to discover the mechanisms responsible for the interactions between aerosol particles and surfaces in a range of air flow conditions. The project expects to transform our understanding of particle deposition through a combination of novel laser-based diagnostic techniques, optical coherence tomography, and state of the art particle formulation methodologies. Expected outcomes of the project include delivery of new methods to optimise particle deposition, development of tunable powder formulations, as well as definition of particle-surface interaction mechanisms in flows. The project should provide significant benefits to particle systems for applications ranging from additive manufacturing to aerosol delivery.Read moreRead less
Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour ....Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour requirement, higher production rate and better quality control than conventional production methods. The new process will combine benefits from both supercritical fluid technology (green process) and microfluidics (high mass & heat transfer).Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101030
Funder
Australian Research Council
Funding Amount
$368,446.00
Summary
Monoatomic metal doping of carbon-based nanomaterials for hydrogen storage. This project aims to present a new concept of monoatomic metal doped carbon-based nanomaterials as advanced solid-state hydrogen storage materials (S-HSMs) for hydrogen fuel cells. The key feature for this synthesis is the use of the unique “defect” structures in carbon lattice as the efficient anchoring sites to immobilise the metal species at atomic level. This project is expected to create new knowledge of atomic inte ....Monoatomic metal doping of carbon-based nanomaterials for hydrogen storage. This project aims to present a new concept of monoatomic metal doped carbon-based nanomaterials as advanced solid-state hydrogen storage materials (S-HSMs) for hydrogen fuel cells. The key feature for this synthesis is the use of the unique “defect” structures in carbon lattice as the efficient anchoring sites to immobilise the metal species at atomic level. This project is expected to create new knowledge of atomic interface catalysis and develop practical applications of S-HSMs in storage tanks for fuel cells, leading to reduction of carbon dioxide emissions and alleviation of air pollution. The success of this project will greatly enhance the Australian clean energy industries.Read moreRead less
Data-driven monitoring of raceway dynamics in ironmaking blast furnaces. Raceway dynamics in ironmaking blast furnaces affect operational stability and cost considerably, yet their dynamic behaviour has not been well monitored online. The project aims to develop a data-driven model for monitoring the internal state of gas-solid-powder reacting flow in the raceway and predicting raceway anomalies online. It will be achieved by combining particle-fluid numerical simulations with data processing an ....Data-driven monitoring of raceway dynamics in ironmaking blast furnaces. Raceway dynamics in ironmaking blast furnaces affect operational stability and cost considerably, yet their dynamic behaviour has not been well monitored online. The project aims to develop a data-driven model for monitoring the internal state of gas-solid-powder reacting flow in the raceway and predicting raceway anomalies online. It will be achieved by combining particle-fluid numerical simulations with data processing and reduced-order state observer, supported by lab/plant experiments, and collaborating with two industry partners from coal and steel industries. The project outcomes including codes, models and raceway control strategies can help promote Australian metallurgical coal's global markets and ultimately the Australian economy.Read moreRead less
High-load powder dispersion and aerosol delivery: an integrated approach. This project aims to develop a novel design toolbox that can accurately predict dispersion performance of a range of powder systems for high-dose inhaler devices. The project expects to provide the pharmaceutical industry with a cornerstone technology to facilitate the design and optimisation of new powder delivery devices. Outcomes are expected to include new knowledge on powder dispersion behaviour that can be applied to ....High-load powder dispersion and aerosol delivery: an integrated approach. This project aims to develop a novel design toolbox that can accurately predict dispersion performance of a range of powder systems for high-dose inhaler devices. The project expects to provide the pharmaceutical industry with a cornerstone technology to facilitate the design and optimisation of new powder delivery devices. Outcomes are expected to include new knowledge on powder dispersion behaviour that can be applied to various industry sectors, including the environmental, bulk chemical and food industries where the majority of products are in powder form. This knowledge will provide significant benefits to industry through provision of a toolkit that can be used to improve final powder-based product quality.Read moreRead less
Model studies of Australian lump ore applied to blast furnace ironmaking. Ore lump use in ironmaking blast furnaces (BFs) requires no preprocessing and has a lower carbon footprint. However, it suffers various technical problems. This project aims to understand and optimize the conditions for such operations. This will be achieved by means of a combined theoretical and experimental program, involving the use of state-of-the-art multiscale computer modelling and simulation techniques. The researc ....Model studies of Australian lump ore applied to blast furnace ironmaking. Ore lump use in ironmaking blast furnaces (BFs) requires no preprocessing and has a lower carbon footprint. However, it suffers various technical problems. This project aims to understand and optimize the conditions for such operations. This will be achieved by means of a combined theoretical and experimental program, involving the use of state-of-the-art multiscale computer modelling and simulation techniques. The research outcomes will be tested in the design and control of lump charging operations in practice through collaboration with the industrial partner. This will ultimately increase Australian ore lump usage in BFs, leading to significant financial and environmental benefits to Australia and the entire steel industry worldwide.Read moreRead less
Modelling of polydisperse particle-fluid reacting flows. Complex polydisperse particle-fluid reacting flows are widely practised in many industries where particle size distribution is wide and particle number is huge, yet the process design and optimisation are hindered by the lack of fundamental understanding of the complex reacting flows, particularly polydispersity and interactions. The project will tackle this specific challenge by developing a novel particle-scale mathematical model by inco ....Modelling of polydisperse particle-fluid reacting flows. Complex polydisperse particle-fluid reacting flows are widely practised in many industries where particle size distribution is wide and particle number is huge, yet the process design and optimisation are hindered by the lack of fundamental understanding of the complex reacting flows, particularly polydispersity and interactions. The project will tackle this specific challenge by developing a novel particle-scale mathematical model by incorporating new numerical techniques of interphase heat/mass transfers, polydispersity and computation speed-up; and applying it to two typical industry processes for demonstration. The outcomes will be applied across a range of industries of vital importance to Australian economic and technological future.Read moreRead less
Engineering improved fat encapsulation for food powders. Encapsulation of fats and oils into powders has wide applications in the food industry, with products including creamers, soups, infant formula, and nutraceutical powders. Spray drying of liquid emulsions into powders is an integral part to manufacture high value products by extending their shelf life, nutritional content, and functionality. This project will generate new protocols for the production of high-fat powders, with direct commer ....Engineering improved fat encapsulation for food powders. Encapsulation of fats and oils into powders has wide applications in the food industry, with products including creamers, soups, infant formula, and nutraceutical powders. Spray drying of liquid emulsions into powders is an integral part to manufacture high value products by extending their shelf life, nutritional content, and functionality. This project will generate new protocols for the production of high-fat powders, with direct commercial benefits in improved production efficiency and new product development from recovered ingredients. The knowledge will benefit the manufacturing of food powders in Australia, currently valued around $600M AUD pa, and will potentially expand the variety of product offering for the export market.Read moreRead less