Powder blending for dry powder inhalers: a new approach for direct control of powder structure. Over 80 per cent of pharmaceutical products involve the processing of powders. This project will generate new knowledge of how to assemble fine and cohesive particles into the structure required for dry powder inhaler products, leading to the development of new low-cost medicines in Australia and the Asia Pacific region.
Multi-scale strategy to manage chloramine decay and nitrification in water distribution systems. The generation of knowledge and technologies in preventing chloramine decay would greatly benefit the Australian water industry. The success of the project would provide the highest possible quality of water, both economically and reliably, giving public assurances of microbiological compliance and safe drinking water.
Granular dynamics: characterization, modelling and application. Storage and transport of bulk solids are widely encountered in mineral, metallurgical and chemical industrials which are important to Australia. The design and control of bulk solids handling equipment must be optimised for the efficiency of processing. This project provides a systematic investigation of the techniques used to characterize bulk solids, and applies the new findings to hopper flow and pneumatic conveying. This, togeth ....Granular dynamics: characterization, modelling and application. Storage and transport of bulk solids are widely encountered in mineral, metallurgical and chemical industrials which are important to Australia. The design and control of bulk solids handling equipment must be optimised for the efficiency of processing. This project provides a systematic investigation of the techniques used to characterize bulk solids, and applies the new findings to hopper flow and pneumatic conveying. This, together with the research training offered through the conduct of the work, is very helpful to maintaining Australia’s leading position in bulk solids handling and application in resource, energy, process and allied industries.Read moreRead less
Design a Targeted Delivery System for Probiotics. The project aims to improve the effectiveness of probiotics by developing a targeted delivery system to the colon. This interdisciplinary research will generate new knowledge in the field of microbiota and develop new delivery systems for live microorganisms and other active compounds. Expected outcomes include increased understanding of the factors affecting the viability of probiotics during storage and passage through the gastro-intestinal tra ....Design a Targeted Delivery System for Probiotics. The project aims to improve the effectiveness of probiotics by developing a targeted delivery system to the colon. This interdisciplinary research will generate new knowledge in the field of microbiota and develop new delivery systems for live microorganisms and other active compounds. Expected outcomes include increased understanding of the factors affecting the viability of probiotics during storage and passage through the gastro-intestinal tract, the establishment of probiotics into gut flora, and how this incorporation affects the dynamics of gut microbiota. The new technology can be utilised across a wide range of therapeutics that target the colon to promote the well-being of our society through commercialisation by industry partner.Read moreRead less
Unravelling the mechanics of particle deposition at the micro-scale. This project aims to discover the mechanisms responsible for the interactions between aerosol particles and surfaces in a range of air flow conditions. The project expects to transform our understanding of particle deposition through a combination of novel laser-based diagnostic techniques, optical coherence tomography, and state of the art particle formulation methodologies. Expected outcomes of the project include delivery of ....Unravelling the mechanics of particle deposition at the micro-scale. This project aims to discover the mechanisms responsible for the interactions between aerosol particles and surfaces in a range of air flow conditions. The project expects to transform our understanding of particle deposition through a combination of novel laser-based diagnostic techniques, optical coherence tomography, and state of the art particle formulation methodologies. Expected outcomes of the project include delivery of new methods to optimise particle deposition, development of tunable powder formulations, as well as definition of particle-surface interaction mechanisms in flows. The project should provide significant benefits to particle systems for applications ranging from additive manufacturing to aerosol delivery.Read moreRead less
Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fu ....Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fundamentally understand the relationship between physical-chemical properties and efficacy. Completion of this project aims to produce potent nanoparticle-based adjuvants underpinned by novel manufacturing technology, to ultimately facilitate the development of more effective and protective vaccines for animals and humans.Read moreRead less
Mudstones as methane sources: gas production from coal seam interburden. Carbonaceous mudstones associated with coal measures already exploited for gas present an attractive reservoir of methane. This project seeks to provide methods for accessing this gas. Mudstone associated with coal seam gas developments are very extensive and gas quantities may exceed even that in the coal itself. Further infrastructure and access permits are already in place for coal seam gas recovery. Unlike shale, which ....Mudstones as methane sources: gas production from coal seam interburden. Carbonaceous mudstones associated with coal measures already exploited for gas present an attractive reservoir of methane. This project seeks to provide methods for accessing this gas. Mudstone associated with coal seam gas developments are very extensive and gas quantities may exceed even that in the coal itself. Further infrastructure and access permits are already in place for coal seam gas recovery. Unlike shale, which is fissile, mudstone is much softer, more malleable and plastic, and consequently will respond abnormally to hydraulic fracturing and propping, so new methods proposed to be developed in this project are needed for stimulation.Read moreRead less
Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fu ....Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fundamentally understand the relationship between physical-chemical properties and efficacy. Completion of this project aims to produce potent nanoparticle-based adjuvants underpinned by novel manufacturing technology, to ultimately facilitate the development of more effective and protective vaccines for animals and humans.Read moreRead less
Engineered nanoporous materials and composites having hierarchical structures by emulsion templating. The project aims to develop new and flexible emulsion-templated processes capable of constructing novel nanoporous materials with hierarchical structures. The project has the potential to revolutionise current approaches for making porous materials, and the outcomes will enhance Australia's ability in frontier technologies and advanced materials.
A defect mechanism for oxygen reduction reaction. This project aims to use defective carbon to replace expensive platinum as a catalyst for oxygen reduction reaction (ORR) in fuel cells. Defective carbons incorporating non-precious metals are better than platinum in terms of over-potential, current density and number of electron transfer. They reduce the overall fuel cell cost but their better stability and higher open voltage and power density promise huge commercial benefit. This project is ex ....A defect mechanism for oxygen reduction reaction. This project aims to use defective carbon to replace expensive platinum as a catalyst for oxygen reduction reaction (ORR) in fuel cells. Defective carbons incorporating non-precious metals are better than platinum in terms of over-potential, current density and number of electron transfer. They reduce the overall fuel cell cost but their better stability and higher open voltage and power density promise huge commercial benefit. This project is expected to be important for large-scale implementation of fuel cells.Read moreRead less