Powder blending for dry powder inhalers: a new approach for direct control of powder structure. Over 80 per cent of pharmaceutical products involve the processing of powders. This project will generate new knowledge of how to assemble fine and cohesive particles into the structure required for dry powder inhaler products, leading to the development of new low-cost medicines in Australia and the Asia Pacific region.
Multi-scale strategy to manage chloramine decay and nitrification in water distribution systems. The generation of knowledge and technologies in preventing chloramine decay would greatly benefit the Australian water industry. The success of the project would provide the highest possible quality of water, both economically and reliably, giving public assurances of microbiological compliance and safe drinking water.
Hybrid resonant acoustics for microfluidic materials synthesis. This project aims to demonstrate the feasibility of a new class of sound waves as a microfluidic micronisation platform for high throughput particle synthesis and crystallisation of active pharmaceutical ingredients.It will use theoretical and numerical studies to research the fundamental physics of a hybrid between bulk and surface waves. This platform is expected to improve energy efficiency a thousandfold, providing an economical ....Hybrid resonant acoustics for microfluidic materials synthesis. This project aims to demonstrate the feasibility of a new class of sound waves as a microfluidic micronisation platform for high throughput particle synthesis and crystallisation of active pharmaceutical ingredients.It will use theoretical and numerical studies to research the fundamental physics of a hybrid between bulk and surface waves. This platform is expected to improve energy efficiency a thousandfold, providing an economical and environmental alternative to conventional processes such as spray drying, and potentially transforming practice across the pharmaceutical, food and other industries.Read moreRead less
Granular dynamics: characterization, modelling and application. Storage and transport of bulk solids are widely encountered in mineral, metallurgical and chemical industrials which are important to Australia. The design and control of bulk solids handling equipment must be optimised for the efficiency of processing. This project provides a systematic investigation of the techniques used to characterize bulk solids, and applies the new findings to hopper flow and pneumatic conveying. This, togeth ....Granular dynamics: characterization, modelling and application. Storage and transport of bulk solids are widely encountered in mineral, metallurgical and chemical industrials which are important to Australia. The design and control of bulk solids handling equipment must be optimised for the efficiency of processing. This project provides a systematic investigation of the techniques used to characterize bulk solids, and applies the new findings to hopper flow and pneumatic conveying. This, together with the research training offered through the conduct of the work, is very helpful to maintaining Australia’s leading position in bulk solids handling and application in resource, energy, process and allied industries.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101666
Funder
Australian Research Council
Funding Amount
$395,588.00
Summary
Engineering nanoparticles with enhanced adhesion at the nano-bio interfaces. This project aims to develop a next-generation adhesive nanoparticle platform through in-depth understandings of nanoparticle interactions with bio-interfaces. This project expects to generate new knowledge in the multidisciplinary research field at nano-bio-interfaces by using a recently developed nano-colloidal probe technology, instructing the rational design of nanoparticles with enhanced interface adhesive properti ....Engineering nanoparticles with enhanced adhesion at the nano-bio interfaces. This project aims to develop a next-generation adhesive nanoparticle platform through in-depth understandings of nanoparticle interactions with bio-interfaces. This project expects to generate new knowledge in the multidisciplinary research field at nano-bio-interfaces by using a recently developed nano-colloidal probe technology, instructing the rational design of nanoparticles with enhanced interface adhesive properties. Expected outcomes include a family of adhesive nanoparticles designed for nanopesticide and animal feed applications, with the potential to deliver valuable intellectual property of commercial interest and economic benefit through technology advancement.Read moreRead less
Particle scale modelling and analysis of the multiphase flows in coal preparation. Australia is the world's biggest coal exporter, and black coal is Australia's largest export, with an annual value >$20 billion. Optimum design and control of the processes in coal preparation play a critical economic role in coal production. This project aims at providing substantial improvements through the application of a novel combined continuum and discrete modelling method. Specifically, the improvements ta ....Particle scale modelling and analysis of the multiphase flows in coal preparation. Australia is the world's biggest coal exporter, and black coal is Australia's largest export, with an annual value >$20 billion. Optimum design and control of the processes in coal preparation play a critical economic role in coal production. This project aims at providing substantial improvements through the application of a novel combined continuum and discrete modelling method. Specifically, the improvements targeted relate to better process and product control, a decrease in unit energy consumption and improvements in productivity, which, together with the research training offered, will further enhance Australia's leading position in global coal industry.Read moreRead less
Design a Targeted Delivery System for Probiotics. The project aims to improve the effectiveness of probiotics by developing a targeted delivery system to the colon. This interdisciplinary research will generate new knowledge in the field of microbiota and develop new delivery systems for live microorganisms and other active compounds. Expected outcomes include increased understanding of the factors affecting the viability of probiotics during storage and passage through the gastro-intestinal tra ....Design a Targeted Delivery System for Probiotics. The project aims to improve the effectiveness of probiotics by developing a targeted delivery system to the colon. This interdisciplinary research will generate new knowledge in the field of microbiota and develop new delivery systems for live microorganisms and other active compounds. Expected outcomes include increased understanding of the factors affecting the viability of probiotics during storage and passage through the gastro-intestinal tract, the establishment of probiotics into gut flora, and how this incorporation affects the dynamics of gut microbiota. The new technology can be utilised across a wide range of therapeutics that target the colon to promote the well-being of our society through commercialisation by industry partner.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100040
Funder
Australian Research Council
Funding Amount
$1,375,000.00
Summary
An advanced electron microscope facility for nanomaterials, functional materials and minerals. An advanced electron microscope facility for nanomaterials, functional materials and minerals: Recent advances in electron microscopy provide instruments that can resolve at the atomic level and image both morphologically and chemically at these resolutions. These modern instruments are also less complex to operate therefore allowing many more researchers to access them directly. The High Resolution Sc ....An advanced electron microscope facility for nanomaterials, functional materials and minerals. An advanced electron microscope facility for nanomaterials, functional materials and minerals: Recent advances in electron microscopy provide instruments that can resolve at the atomic level and image both morphologically and chemically at these resolutions. These modern instruments are also less complex to operate therefore allowing many more researchers to access them directly. The High Resolution Scanning Transmission Electron Microscope will allow a complete, nano-scale characterisation of natural and synthetic materials in a broad range of scientific, engineering and industrial applications. The Field Emission Scanning Electron Microscope will provide nano-science users with a tool that can image many of the processes in the formation of these nanostructures and particles.Read moreRead less
Experimentally validated theory for the mixing of granular materials. The project aims to develop better mixing theories to support industrial applications. Effective mixing of granular materials such as aggregates in building industry and stockpiles in mineral processing is important for creating homogeneous products, yet industrial mixers lack scientific design and operate with no control of mixture quality. The project aims to establish a new general continuum mixing theory, which will be val ....Experimentally validated theory for the mixing of granular materials. The project aims to develop better mixing theories to support industrial applications. Effective mixing of granular materials such as aggregates in building industry and stockpiles in mineral processing is important for creating homogeneous products, yet industrial mixers lack scientific design and operate with no control of mixture quality. The project aims to establish a new general continuum mixing theory, which will be validated against X-ray measurements of grain motions within small mixers. By describing the theory using an accurate computational method, the simulations of these mixers will be scalable, and would help deliver predictions for particle mixing in much larger operations. Other expected outcomes are to control mixture quality and reduce industry reliance on costly and time-consuming trial-and-error experiments.Read moreRead less
The role of electrostatic charge in airway deposition of aerosols. This project aims to unravel the importance of electrostatic charge in controlling deposition of aerosols in the respiratory tract. The expected outcome is a validated mathematical model for accurately predicting deposition behaviour of charged aerosol particles in human airways. Findings may ultimately be used to underpin novel prevention measures to reduce lung deposition of inhaled hazardous airborne particles to significantly ....The role of electrostatic charge in airway deposition of aerosols. This project aims to unravel the importance of electrostatic charge in controlling deposition of aerosols in the respiratory tract. The expected outcome is a validated mathematical model for accurately predicting deposition behaviour of charged aerosol particles in human airways. Findings may ultimately be used to underpin novel prevention measures to reduce lung deposition of inhaled hazardous airborne particles to significantly reduce health risks and costs. They may also be used to enable the development of new inhalation technologies based on electrostatic charge to improve aerosol drug delivery to the lungs of patients with respiratory diseases.Read moreRead less