Identifying genes causing thermal evolution of ectotherm body size. Cold-blooded animals increase in body size as they are found in populations at greater distances from the equator. These patterns are due to populations adapting to temperature. The aim of this project is to identify the genes involved in this adaptation process. We will do this by taking advantage of a well-studied body size cline in the vinegar fly on the east coast of Australia, and by building on an international collaborati ....Identifying genes causing thermal evolution of ectotherm body size. Cold-blooded animals increase in body size as they are found in populations at greater distances from the equator. These patterns are due to populations adapting to temperature. The aim of this project is to identify the genes involved in this adaptation process. We will do this by taking advantage of a well-studied body size cline in the vinegar fly on the east coast of Australia, and by building on an international collaboration between a leading UK and two Australian research groups. In doing so we will provide an explanation at the molecular level for one of the great unresolved phenomena in biology: why do cold-blooded animals get bigger in the cold? The research also leads to the potential to manipulate body size in animals.Read moreRead less
Evolutionary genetics of bovid genomes over 60,000 years. This project will provide data critical for understanding the genetic background of modern cattle and bison, and how humans have shaped factors such as milk yield, growth rates and muscle mass. It will also reveal genes and genomic regions that were favoured in the domestication process, including those potentially linked to genes of commercial interest for future research. This pioneering ancient DNA approach will also be applicable to a ....Evolutionary genetics of bovid genomes over 60,000 years. This project will provide data critical for understanding the genetic background of modern cattle and bison, and how humans have shaped factors such as milk yield, growth rates and muscle mass. It will also reveal genes and genomic regions that were favoured in the domestication process, including those potentially linked to genes of commercial interest for future research. This pioneering ancient DNA approach will also be applicable to a variety of other domestic crops and animals. The unique temporal analysis of microevolution will provide crucial data for genetic research, and groundproof our attempts to analyse the timing and nature of human evolutionary history, major domestication events and inform conservation management.Read moreRead less
Rapid delineation of genetic provenance for rehabilitation and revegetation of native plant communities. The rehabilitation and/or revegetation of degraded, remnant or post-mining bushland is an increasingly important activity. Data and general principles for the delineation of genetic provenance are urgently required for effective rehabilitation, as well as for the conservation of genetic diversity. We will apply a new and powerful genetic technique for the rapid delineation of provenance in ....Rapid delineation of genetic provenance for rehabilitation and revegetation of native plant communities. The rehabilitation and/or revegetation of degraded, remnant or post-mining bushland is an increasingly important activity. Data and general principles for the delineation of genetic provenance are urgently required for effective rehabilitation, as well as for the conservation of genetic diversity. We will apply a new and powerful genetic technique for the rapid delineation of provenance in over 30 native plant species in south west Australia. Our aim is to generate provenance guidelines and principles, as well as provenance data for the most important species for bushland rehabilitation, which will be produced for rehabilitation practitioners through a "provenance atlas" book.Read moreRead less
Genetic architecture of species divergence and hybridisation in eucalypts. Eucalypts are an icon of Australia and are of great economic and ecological significance to the nation. They are the most widely planted hardwood trees in the world, but Australia is the centre of origin of most species and the custodian of this important native bioresource. Understanding the evolutionary processes that shape diversity in this internationally significant genus is important for its long-term management a ....Genetic architecture of species divergence and hybridisation in eucalypts. Eucalypts are an icon of Australia and are of great economic and ecological significance to the nation. They are the most widely planted hardwood trees in the world, but Australia is the centre of origin of most species and the custodian of this important native bioresource. Understanding the evolutionary processes that shape diversity in this internationally significant genus is important for its long-term management and conservation. This project links to large international initiatives currently underway for high-density mapping and sequencing of the eucalypt genome, to enhance the flow of information gained back to Australia for scientific, economic and environmental benefit.Read moreRead less
Liver fluke: improving disease control through understanding of parasite diversity, drug resistance and better diagnosis. The benefits from this research include: (i) development of knowledge that will allow a better use of existing drug formulations to protect livestock from fasciolosis, potentially generating economic benefits to Australian producers of up to $50-80m/year; (ii) improved application of new commercial therapies for fasciolosis in ruminants, improving producer prosperity; (iii) ....Liver fluke: improving disease control through understanding of parasite diversity, drug resistance and better diagnosis. The benefits from this research include: (i) development of knowledge that will allow a better use of existing drug formulations to protect livestock from fasciolosis, potentially generating economic benefits to Australian producers of up to $50-80m/year; (ii) improved application of new commercial therapies for fasciolosis in ruminants, improving producer prosperity; (iii) enhanced training opportunities for graduate students that will build human capacity in technologies such as molecular diagnostics which have a wide application across the animal sectors; (iv) enhancement of our capacity to respond to unexpected future threats in production animals.Read moreRead less
The future of fruit fly control: making the Sterile Insect Technique work for Queensland fruit fly. The future of fruit fly control in Australia lies in the Sterile Insect Technique (SIT): it is the only non-pesticide option that can totally eliminate pest populations. Millions of dollars have already been invested to establish an SIT program against Queensland fruit fly (Q-fly) in southern and eastern Australia, but this program is currently largely ineffective due to the poor performance of t ....The future of fruit fly control: making the Sterile Insect Technique work for Queensland fruit fly. The future of fruit fly control in Australia lies in the Sterile Insect Technique (SIT): it is the only non-pesticide option that can totally eliminate pest populations. Millions of dollars have already been invested to establish an SIT program against Queensland fruit fly (Q-fly) in southern and eastern Australia, but this program is currently largely ineffective due to the poor performance of the mass-reared sterile flies. This project will apply genetic, ecological and technical solutions to the problems facing the current Q-fly control program. Effective control of Q-fly will enhance the international competitiveness of Australia's horticultural industries.Read moreRead less
Analysing and modelling molecular rate variation among nuclear and mitochondrial genomes. My research will have important practical benefits for bioinformaticians and evolutionary biologists, because existing analytical methods will be rigorously tested and new tools will be developed. Australia has a comparatively high concentration of researchers in this field, so my research will foster domestic collaboration and import international expertise. The research will provide important insights int ....Analysing and modelling molecular rate variation among nuclear and mitochondrial genomes. My research will have important practical benefits for bioinformaticians and evolutionary biologists, because existing analytical methods will be rigorously tested and new tools will be developed. Australia has a comparatively high concentration of researchers in this field, so my research will foster domestic collaboration and import international expertise. The research will provide important insights into the rates and patterns of genetic changes associated with domestication, and into variation in evolutionary rates among the primate ancestors of humans. In addition to developing new software, which will be made publicly available, I will develop new evolutionary models to supplement existing software packages. Read moreRead less
Genetic variation of the vulnerable Eucalyptus argophloia, and its development for sustainable hardwood forestry in low rainfall areas. We will examine the biodiversity in a vulnerable species of eucalypt, Eucalyptus argophloia. This species is under threat due to land clearing, and only 1000 trees remain in the wild. E. argophloia has great promise for plantation timber in low rainfall areas of Northern Australia. We will breed superior varieties for plantation forestry designed to cope with cl ....Genetic variation of the vulnerable Eucalyptus argophloia, and its development for sustainable hardwood forestry in low rainfall areas. We will examine the biodiversity in a vulnerable species of eucalypt, Eucalyptus argophloia. This species is under threat due to land clearing, and only 1000 trees remain in the wild. E. argophloia has great promise for plantation timber in low rainfall areas of Northern Australia. We will breed superior varieties for plantation forestry designed to cope with climate change, low rainfall and salinity. This project will help to manage and preserve the species in the wild and create profitable and sustainable timber plantations on marginal lands.Read moreRead less
Fire, bees and other disturbances: the basis for variation in genetic diversity in long-lived plants. An understanding of processes generating temporal and spatial patterns of genetic diversity in perennial plants must underpin successful conservation. Our long-term study will exploit systems in the family Proteaceae in which we have completed foundation studies. We will develop and extend molecular techniques to measure (i) genetic changes from seed to adult, (ii) gene flow by different pollina ....Fire, bees and other disturbances: the basis for variation in genetic diversity in long-lived plants. An understanding of processes generating temporal and spatial patterns of genetic diversity in perennial plants must underpin successful conservation. Our long-term study will exploit systems in the family Proteaceae in which we have completed foundation studies. We will develop and extend molecular techniques to measure (i) genetic changes from seed to adult, (ii) gene flow by different pollinator classes, and (iii) genetic contamination by foreign gene pools, in systems affected by introduced pollinators and natural and cultivar hybridization. Most importantly, we will use fire as an accelerant of generational change and test fitness consequences of changes in genotypic diversity.Read moreRead less
Characterization of the tammar wallaby MHC. We will be able to determine the immunological fitness of marsupial populations which will help us to conserve our native fauna and protect our eco-tourism industry.
We will work in the international arena of large scale genomics and bring new technologies to Australia.