Special Research Initiatives - Grant ID: SR0354622
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network ....Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network is unique, timely and strategic in that it will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory ne ....ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory networks and to address how environmental factors impinge on these regulatory networks. The formation of this National Research Network is unique, timely and strategic. It will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
Plasticity in placental vasculature and the evolution of viviparity in lizards. This cross-disciplinary research will provide thorough understanding of the reproductive physiology of animals with different forms of reproduction, information critical for conservation and management of Australia's biodiversity. Australia's unique reptiles provide the best animal system in the world for research in this area. Our research on maternal-embryonic interactions in this animal model has direct implicatio ....Plasticity in placental vasculature and the evolution of viviparity in lizards. This cross-disciplinary research will provide thorough understanding of the reproductive physiology of animals with different forms of reproduction, information critical for conservation and management of Australia's biodiversity. Australia's unique reptiles provide the best animal system in the world for research in this area. Our research on maternal-embryonic interactions in this animal model has direct implications for understanding some medical disorders, such as human angiogenic disorders. The research will strengthen ties internationally through research in South Africa, and provide training in combined biological and medical technologies. It will maintain Australia's long-term leadership in this area of research.Read moreRead less
Competition between regulatory processes in Amphibians: Testing the effects of physical and physiological factors on thermoregulation and hydroregulation. Regulation of body temperature is important for many animals, and it influences processes such as growth and reproduction. However, it is not clear to what extent wet-skinned animals can control body temperature because of evaporation. Understanding this about frogs is crucial to understanding their habitat requirements and the effects of clim ....Competition between regulatory processes in Amphibians: Testing the effects of physical and physiological factors on thermoregulation and hydroregulation. Regulation of body temperature is important for many animals, and it influences processes such as growth and reproduction. However, it is not clear to what extent wet-skinned animals can control body temperature because of evaporation. Understanding this about frogs is crucial to understanding their habitat requirements and the effects of climate change, habitat modification, and the invasion of cane toads on their populations. Amphibians are in decline worldwide, and research into the basic ways that these animals interact with the physical environment is needed before effective management plans can be produced. The unique physiological characteristics of Australian frogs make this is the best place in the world to do this research.Read moreRead less
Do frogs hydroregulate? Regulation versus tolerance of thermal and hydric states. Amphibians are in decline in Australia and worldwide. Frogs are a middle link in terrestrial and aquatic food chains (as predators and prey) so are important for the sustainability of Australia's biodiversity and as indicators of environmental problems. Basic research about the ways Australian frogs interact with the physical environment to balance body water and temperature is crucial to predicting the effects of ....Do frogs hydroregulate? Regulation versus tolerance of thermal and hydric states. Amphibians are in decline in Australia and worldwide. Frogs are a middle link in terrestrial and aquatic food chains (as predators and prey) so are important for the sustainability of Australia's biodiversity and as indicators of environmental problems. Basic research about the ways Australian frogs interact with the physical environment to balance body water and temperature is crucial to predicting the effects of climate change or habitat modification on frogs. This basic information is needed to produce effective conservation plans for native frogs and management plans for invasive cane toads. We will train students in techniques and concepts in ecology, conservation biology, and animal physiology.Read moreRead less
Mechanisms of enhancement of absorption of poorly water-soluble drugs from the gastrointestinal tract mediated by lipids, surfactants and polymers. This project will provide technological advances with significant benefits in terms of improved drug treatment, and therefore health outcomes for Australia. The projects builds on internationally recognised research strengths at Monash University in lipid-based drug delivery, and connects Monash and Australia with applied research in the multination ....Mechanisms of enhancement of absorption of poorly water-soluble drugs from the gastrointestinal tract mediated by lipids, surfactants and polymers. This project will provide technological advances with significant benefits in terms of improved drug treatment, and therefore health outcomes for Australia. The projects builds on internationally recognised research strengths at Monash University in lipid-based drug delivery, and connects Monash and Australia with applied research in the multinational pharmaceutical industry. This will enhance the standing of Australian biomedical research in the pharmaceutical world and directly facilitate a partnership between Monash and Capsugel in commercialisation of the outcomes of the project. The project will also train Australian scientists in skills that are in great demand in the developing pharmaceutical industry in Australia.Read moreRead less
Afferent stimulation-induced plasticity and its functional significance. Certain regions of the brain can reorganise (plasticity) during motor learning or when there is damage to peripheral nerves or muscles. There is a large body of evidence for these plastic changes in animals. Until recently data showing that similar changes occurred in humans was limited. However, we have recently demonstrated that certain patterns of peripheral stimulation can indeed induce similar changes in human subjects ....Afferent stimulation-induced plasticity and its functional significance. Certain regions of the brain can reorganise (plasticity) during motor learning or when there is damage to peripheral nerves or muscles. There is a large body of evidence for these plastic changes in animals. Until recently data showing that similar changes occurred in humans was limited. However, we have recently demonstrated that certain patterns of peripheral stimulation can indeed induce similar changes in human subjects. These findings are important for our understanding of the mechanisms of motor control and learning.Read moreRead less
Calcium regulation in the skeletal muscle triad and along the fibre. The fundamental role of skeletal muscle is posture and movement. Alterations in the normal way calcium regulates skeletal muscle function in fatigue, age and disease states causes loss of normal function. Preventing or controlling these changes is a key therapeutic aim. However, we currently lack full understanding of key mechanisms of calcium regulation in healthy skeletal muscle. This project will define key aspects of cal ....Calcium regulation in the skeletal muscle triad and along the fibre. The fundamental role of skeletal muscle is posture and movement. Alterations in the normal way calcium regulates skeletal muscle function in fatigue, age and disease states causes loss of normal function. Preventing or controlling these changes is a key therapeutic aim. However, we currently lack full understanding of key mechanisms of calcium regulation in healthy skeletal muscle. This project will define key aspects of calcium regulation that could be crucial to developing targets for improving function of skeletal muscle under stressed states.Read moreRead less
Who determines gestation length - mother or fetus? This project will extend our knowledge of a key biological process - pregnancy. Variation of gestation length by 10% is generally deleterious to the offspring, and smaller babies have been shown to be more susceptible to later life diseases. Therefore, extension of the information gained from this project will likely impact researchers in species conservation, pest control, and the livestock industries, as well as human, obstetric care and pract ....Who determines gestation length - mother or fetus? This project will extend our knowledge of a key biological process - pregnancy. Variation of gestation length by 10% is generally deleterious to the offspring, and smaller babies have been shown to be more susceptible to later life diseases. Therefore, extension of the information gained from this project will likely impact researchers in species conservation, pest control, and the livestock industries, as well as human, obstetric care and practice. Specifically, knowledge gained from this project may lead to means of limiting (pest control) as well as enhancing (endangered species) species survival.Read moreRead less
ION CHANNELS FORMED BY SMALL PROTEINS FROM VIRUSES. Movements of ions across cell membranes through protein ion channels are essential for normal cell function. We have found that some small proteins from viruses can form ion channels. Studying these simple channels should give us clues about the function of more complex channels, such as those in the brain, as well as giving us information about the viruses themselves. We will test whether a small protein from Ross River virus forms ion channel ....ION CHANNELS FORMED BY SMALL PROTEINS FROM VIRUSES. Movements of ions across cell membranes through protein ion channels are essential for normal cell function. We have found that some small proteins from viruses can form ion channels. Studying these simple channels should give us clues about the function of more complex channels, such as those in the brain, as well as giving us information about the viruses themselves. We will test whether a small protein from Ross River virus forms ion channels and will also test the effects of selected mutations in proteins from influenza and AIDS viruses that we have shown previously to form ion channels.Read moreRead less