Predicting the Impact of Damming on the Endangered Mary River Turtle. Little is known about the effects of inland river alteration on the ecology of freshwater turtles, where river damming results in dramatic changes in river physical, chemical and biological characteristics. In Australia there are 446 large dams, necessary for hydro-electric power, navigation, flood control, irrigation and drinking water. Many of these rivers are inhabited by freshwater turtles, endemic to Australia, and this ....Predicting the Impact of Damming on the Endangered Mary River Turtle. Little is known about the effects of inland river alteration on the ecology of freshwater turtles, where river damming results in dramatic changes in river physical, chemical and biological characteristics. In Australia there are 446 large dams, necessary for hydro-electric power, navigation, flood control, irrigation and drinking water. Many of these rivers are inhabited by freshwater turtles, endemic to Australia, and this project will assess the impact of changes in habitat quality on the endangered Mary River Turtle (Elusor macrurus). The study comes at a timely opportunity, as proposed river damming will substantially alter the turtles' habitat, and its survival potential remains unknown.Read moreRead less
Mechanisms of enhancement of absorption of poorly water-soluble drugs from the gastrointestinal tract mediated by lipids, surfactants and polymers. This project will provide technological advances with significant benefits in terms of improved drug treatment, and therefore health outcomes for Australia. The projects builds on internationally recognised research strengths at Monash University in lipid-based drug delivery, and connects Monash and Australia with applied research in the multination ....Mechanisms of enhancement of absorption of poorly water-soluble drugs from the gastrointestinal tract mediated by lipids, surfactants and polymers. This project will provide technological advances with significant benefits in terms of improved drug treatment, and therefore health outcomes for Australia. The projects builds on internationally recognised research strengths at Monash University in lipid-based drug delivery, and connects Monash and Australia with applied research in the multinational pharmaceutical industry. This will enhance the standing of Australian biomedical research in the pharmaceutical world and directly facilitate a partnership between Monash and Capsugel in commercialisation of the outcomes of the project. The project will also train Australian scientists in skills that are in great demand in the developing pharmaceutical industry in Australia.Read moreRead less
Development of novel vaccine delivery systems for induction of mucosal immunity in a large animal model. The induction of mucosal immune responses is a highly desirable goal in vaccine research and development, as it prevents entry of the large number of mucosal pathogens. This proposal aims to develop new mucosal vaccine delivery systems by combining intra-nasal, intra-lung and transcutaneous vaccine delivery with ISCOM-based adjuvants. The nature of the immune response will be analysed in real ....Development of novel vaccine delivery systems for induction of mucosal immunity in a large animal model. The induction of mucosal immune responses is a highly desirable goal in vaccine research and development, as it prevents entry of the large number of mucosal pathogens. This proposal aims to develop new mucosal vaccine delivery systems by combining intra-nasal, intra-lung and transcutaneous vaccine delivery with ISCOM-based adjuvants. The nature of the immune response will be analysed in real time using a sheep cannulation model. Subsequently, the efficacy of mucosal vaccination strategies will be tested in a chlamydia infection model.Read moreRead less