Finding the targets of natural products in complex botanical extracts. Many plants are used for nutritional and traditional medicine purposes and have demonstrated, evidence based effects. However, standard methods to identify single chemical compounds responsible for the observed effects fail as they rely on a single compound having a single target and ignore the overall effects of many interacting compounds on many targets. In this application we propose a new method to simultaneously identify ....Finding the targets of natural products in complex botanical extracts. Many plants are used for nutritional and traditional medicine purposes and have demonstrated, evidence based effects. However, standard methods to identify single chemical compounds responsible for the observed effects fail as they rely on a single compound having a single target and ignore the overall effects of many interacting compounds on many targets. In this application we propose a new method to simultaneously identify the molecular targets of many compounds in complex plant extracts, along with their subsequent validation by responses in gene expression to the plant extract. This research will revolutionise understanding of the nutritional and medicinal effects of plants and will allow our partners to accelerate commercialisation. Read moreRead less
The Influence Of Caregiver Supervision On The Risk Of Child Drowning And Injury At The Beach.
Funder
National Health and Medical Research Council
Funding Amount
$60,125.00
Summary
The aim of this research is to gain a comprehensive understanding of the role of caregiver beliefs, perceptions and behaviours in relation to child injury risk, drowning and injury prevention in beach settings. Findings will provide baseline evidence quantifying the function of supervision as a risk and protective factor for child drowning and injuries. Increased understanding of this relationship in beach settings will guide future development of injury and drowning prevention strategies.