Understanding production and application of alpha emitting radionuclides. This project aims to develop new materials to improve the efficiency of production of radionuclides, as well as tools to improve our understanding of isotope decay products to to improve efficiency of delivery. High performance polymers will be evaluated to establish optimal design properties for enhanced radionuclide collection from novel generators of isotopic lead (Pb-212), and new methods will be developed to improve u ....Understanding production and application of alpha emitting radionuclides. This project aims to develop new materials to improve the efficiency of production of radionuclides, as well as tools to improve our understanding of isotope decay products to to improve efficiency of delivery. High performance polymers will be evaluated to establish optimal design properties for enhanced radionuclide collection from novel generators of isotopic lead (Pb-212), and new methods will be developed to improve understanding of isotope product stability. Anticipated outcomes will provide greater production and utility of radioisotopes in radiopharmaceuticals, while building strong ties with partner AdvanCell Isotopes. This could improve manufacture of radionuclides, expanding capability and applications in radiopharmaceuticals.Read moreRead less
Understanding and controlling neuropeptide GPCR-transducer coupling. G protein-coupled receptors (GPCRs) are physiologically essential, yet the spatiotemporal complexity of receptor function has limited our understanding of their function and success in drug development. Using a multi-disciplinary approach integrating GPCR signalling, trafficking and drug delivery, this research program aims to understand, and control, the molecular mechanisms that enable a single receptor to respond to differen ....Understanding and controlling neuropeptide GPCR-transducer coupling. G protein-coupled receptors (GPCRs) are physiologically essential, yet the spatiotemporal complexity of receptor function has limited our understanding of their function and success in drug development. Using a multi-disciplinary approach integrating GPCR signalling, trafficking and drug delivery, this research program aims to understand, and control, the molecular mechanisms that enable a single receptor to respond to different ligands to promote unique cellular processes. The anticipated outcomes include an enhanced capacity for understanding fundamental biology, and stronger national and international collaborations. It will provide significant benefits including expanded basic knowledge and advancement of drug delivery technology.Read moreRead less
Synergising nanoemulsion and lipid biomimetic design for advanced delivery. This project aims to identify the critical design characteristics of lipid formulations of lipid-modified probes or drugs (lipid biomimetics) that together promote integration into lipid absorption pathways and target the lymphatic system that drains the small intestine. This has significant potential since the intestinal lymphatic system is a key immune tissue, the site of immune response to autoantigens and antigens de ....Synergising nanoemulsion and lipid biomimetic design for advanced delivery. This project aims to identify the critical design characteristics of lipid formulations of lipid-modified probes or drugs (lipid biomimetics) that together promote integration into lipid absorption pathways and target the lymphatic system that drains the small intestine. This has significant potential since the intestinal lymphatic system is a key immune tissue, the site of immune response to autoantigens and antigens derived from food and the microbiome. The project will deliver a design roadmap of the required characteristics for lymphatic targeting, and in particular, will identify novel lipid nanoemulsions that work synergistically with lipid biomimetics to enhance lymphatic imaging and delivery applications.Read moreRead less