The Centre will enhance Australian clinical immunisation research and training, focussing upon clinical questions with translatable outcomes not easily addressed by industry. Optimal immunisation and interventions to maximise uptake of existing and new vaccines in high risk patient groups, such as children with cancer, immigrants, children with chronic diseases and adolescents will be studied. New vaccine trials, innovative use of existing vaccines, systematic collection of vaccine failure data, ....The Centre will enhance Australian clinical immunisation research and training, focussing upon clinical questions with translatable outcomes not easily addressed by industry. Optimal immunisation and interventions to maximise uptake of existing and new vaccines in high risk patient groups, such as children with cancer, immigrants, children with chronic diseases and adolescents will be studied. New vaccine trials, innovative use of existing vaccines, systematic collection of vaccine failure data, and targeted epidemiology and disease modelling vaccine preventable disease will also allow a broad program of research, enabling training and mentoring of young clinical nurse and physician researchers. Collaborations with existing national immunisation, infectious diseases and research institutions will allow maximal effectiveness of clinical studies.Read moreRead less
Effectiveness of social skills training for children with autism. Our industry partner, Aspect Australia, is one of the world's largest providers of educational and other services for people with autism. The demonstration of effectiveness of the program in Aspect classes will likely lead to widespread use and benefit of the program in the education sector nationally and internationally. This in turn would lead to potential lessening of disability in children with autism with improvements in thei ....Effectiveness of social skills training for children with autism. Our industry partner, Aspect Australia, is one of the world's largest providers of educational and other services for people with autism. The demonstration of effectiveness of the program in Aspect classes will likely lead to widespread use and benefit of the program in the education sector nationally and internationally. This in turn would lead to potential lessening of disability in children with autism with improvements in their mental health and significant cost savings to the community.Read moreRead less
The Effects Of Estrogen-Responsive B Box Protein On Retinoid Sensitivity In Cancer And Its Significance In Development
Funder
National Health and Medical Research Council
Funding Amount
$82,421.00
Summary
Although effective, many cancer drugs often lead to side effects, especially in children. New therapies are needed that specifically target cancer cells while leaving normal cells unaffected. I am studying a novel protein (EBBP) which I believe has an important role in cancer cell growth. By studying EBBP I aim to be able to increase the effectiveness of the low toxic chemotherapy retinoic acid without increased side effects, as well as understand the functional role of EBBP in cancer cells.
Tracking blood and blood products for a healthy start to life. This project will aim to coalesce multiple data sources to track blood and blood products from supply to recipient and improve safe and appropriate blood product transfusions for mothers and newborns. Tracking blood will assist in early identification of adverse outcomes. Identification of at-risk women and babies will allow early prevention and treatment.
Psychosocial and economic impacts of rare diseases on Australian children, families and health professionals. Rare childhood diseases have enormous impacts on children and families; health services, and health professionals. This project will enable Australia to lead the international research effort by using a coordinated approach to study the impacts of rare diseases in order to improve psychosocial, health and economic outcomes for children and families.
Discovery Early Career Researcher Award - Grant ID: DE150101921
Funder
Australian Research Council
Funding Amount
$357,000.00
Summary
Effects of reducing sitting on toddlers’ executive functions: Cluster RCT. The levels of sedentary behaviour are now alarmingly high in toddlers, yet little is known about the effect of this behaviour on cognitive development and executive functions during early childhood. This 15 month cluster randomised controlled trial will examine the effects of reduced sitting time on cognitive development and executive functions in Australian toddlers from low socio-economic families. This project aims to ....Effects of reducing sitting on toddlers’ executive functions: Cluster RCT. The levels of sedentary behaviour are now alarmingly high in toddlers, yet little is known about the effect of this behaviour on cognitive development and executive functions during early childhood. This 15 month cluster randomised controlled trial will examine the effects of reduced sitting time on cognitive development and executive functions in Australian toddlers from low socio-economic families. This project aims to develop and implement evidence-based strategies and policies designed to optimise developmental and health outcomes in young children, specifically in those from a low socio-economic status, thus giving young children the best start in life.Read moreRead less
Molecular and antibody analysis of cytomegalovirus (CMV) infection of fetal and placental cells. CMV is a beta herpesvirus with many unknown molecular mechanisms associated with cellular infection. The virus infects placental cells in vivo, although pathogenesis of viral damage to these cells has been extremely difficult to study in vitro. We have commenced a study to i) demonstrate the molecular accompaniments of infection of placental cells in vitro, ii) determine the genotypic characteristics ....Molecular and antibody analysis of cytomegalovirus (CMV) infection of fetal and placental cells. CMV is a beta herpesvirus with many unknown molecular mechanisms associated with cellular infection. The virus infects placental cells in vivo, although pathogenesis of viral damage to these cells has been extremely difficult to study in vitro. We have commenced a study to i) demonstrate the molecular accompaniments of infection of placental cells in vitro, ii) determine the genotypic characteristics of congenital CMV infections, in collaboration with Abbott Diagnostics, and iii) produce an in vivo model of CMV infection to demonstrate the pathogenesis of cellular injury. The combination of molecular expertise at UNSW with monoclonal antibody expertise from Abbott Diagnostics mean this project is unique worldwide.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101588
Funder
Australian Research Council
Funding Amount
$392,459.00
Summary
Do physical activity and electronic screen behaviours influence cognitive and psychosocial development in preschool children? Levels of physical inactivity and screen-based entertainment are alarmingly high among preschool children, yet little is known about the independent effects of these behaviours on cognitive and psychosocial development during early childhood. This project will investigate the associations between physical activity and screen-based entertainment and cognitive and psychosoc ....Do physical activity and electronic screen behaviours influence cognitive and psychosocial development in preschool children? Levels of physical inactivity and screen-based entertainment are alarmingly high among preschool children, yet little is known about the independent effects of these behaviours on cognitive and psychosocial development during early childhood. This project will investigate the associations between physical activity and screen-based entertainment and cognitive and psychosocial development in preschool children. The findings will identify how much and which types of these behaviours influence developmental outcomes in young children. This knowledge will benefit parents, educators, health professionals and governments to develop and implement evidence-based strategies and policies to give young children the best start in life.Read moreRead less
The Clinical Utility Of Small Airway Function Tests In Paediatric Respiratory Disease
Funder
National Health and Medical Research Council
Funding Amount
$64,631.00
Summary
Respiratory disease is an important child health issue with long term implications into adulthood. The evaluation of small airways involvement in disease processes, using an accurate sensitive measures of function, such as forced oscillation technique and multiple breath washout, potentially facilitates not only early detection of disease, but instigation of earlier treatment, better assessment of response to treatment, and ultimately better outcome.
Motor problems, ranging from clumsiness to cerebral palsy, are one of the most common adverse outcomes in children born early. This study will investigate the motor development of children born <30 weeks’ gestation compared with peers born at term from birth to 5 years. We will determine whether early clinical evaluations or neuroimaging in the newborn period can predict later motor impairment at 5 years to be able to identify those who will benefit most from early intervention.