Fluid mechanics and physiology of blockages in vascular systems. Vascular disease is a major health problem both in Australia and worldwide. In particular, cardiovascular disease is a major killer of adult Australians. Engineers and mathematicians working with biologists will gain a greater understanding of vascular diseases, a major health problem, including cardiovascular disease, which is one of the biggest killers worldwide, as well as tackling renal circulation problems, which are a signifi ....Fluid mechanics and physiology of blockages in vascular systems. Vascular disease is a major health problem both in Australia and worldwide. In particular, cardiovascular disease is a major killer of adult Australians. Engineers and mathematicians working with biologists will gain a greater understanding of vascular diseases, a major health problem, including cardiovascular disease, which is one of the biggest killers worldwide, as well as tackling renal circulation problems, which are a significant problem and may contribute to hypertension. Detailed measurement and prediction will be undertaken of the mechanical loading and response of cells to their microenvironment, an important first step to controlling pathological responses which lead to a variety of autoimmune problems.Read moreRead less
Cytorefractometry - a new technique for refractive index tomography of living cells. An ultrahigh-resolution bifocal optical coherence refractometry is proposed, and will result to micron-scale-resolution refractive index tomography of living cells, termed cytorefractometry. This technique represents an extension from bifocal optical coherence refractometry that has recently shown a remarkable promise for direct, several-frames-per-second, motion-artifact-free determination of refractive index ....Cytorefractometry - a new technique for refractive index tomography of living cells. An ultrahigh-resolution bifocal optical coherence refractometry is proposed, and will result to micron-scale-resolution refractive index tomography of living cells, termed cytorefractometry. This technique represents an extension from bifocal optical coherence refractometry that has recently shown a remarkable promise for direct, several-frames-per-second, motion-artifact-free determination of refractive index in turbid media, including biological tissue in vivo. We propose to apply our novel technique to study tissue calcification, a serious problem in cardiology, by making use of the refractive index contrast mechanism. Calcification of smooth muscle cells and aorta subdermal implant models will be studied aiming for prevention of calcification-associated pathologies.Read moreRead less
Asymmetrically Twisted Structures to form High-Power Rotary Micromotors for In-Vivo Swimming Microrobots. Major surgery is traumatic and risky, but often the only choice for the most serious of diseases that affect older people. In this study, we aim to provide doctors with a means to avoid major surgery and extend the capabilities of doctors to diagnose and treat patients using non- and minimally-invasive procedures: a powerful micromotor carrying its own power supply and a special flagellar pr ....Asymmetrically Twisted Structures to form High-Power Rotary Micromotors for In-Vivo Swimming Microrobots. Major surgery is traumatic and risky, but often the only choice for the most serious of diseases that affect older people. In this study, we aim to provide doctors with a means to avoid major surgery and extend the capabilities of doctors to diagnose and treat patients using non- and minimally-invasive procedures: a powerful micromotor carrying its own power supply and a special flagellar propeller to swim within the vascular and digestive systems of the human body to perform tasks via remote control. We also aim to understand the mechanisms underlying the operation of our motor system and flagellar motion in fluids to assist in the understanding of twisted blade structures and propulsion in fluids on the micro-scale.Read moreRead less