Generation of Novel Fermentation Products and their Exploitation in the Synthesis of Biologically Active Organic Compounds with Therapeutic Potential. Collections of new micro-organisms and their metabolites suitable for use in the chemical synthesis programs will emerge from the proposed research. This will provide a potentially highly-valuable national resource that could serve the needs of many laboratories around Australia by allowing them to establish more direct routes to target molecules ....Generation of Novel Fermentation Products and their Exploitation in the Synthesis of Biologically Active Organic Compounds with Therapeutic Potential. Collections of new micro-organisms and their metabolites suitable for use in the chemical synthesis programs will emerge from the proposed research. This will provide a potentially highly-valuable national resource that could serve the needs of many laboratories around Australia by allowing them to establish more direct routes to target molecules being sought in the development of new therapeutic agents and/or materials. The combined application of molecular biological, microbiological and chemical synthesis techniques in a concerted manner in the one location will lead to a raft of new opportunities for the biotech and pharmaceutical industries in Australia.Read moreRead less
ARC Centre of Excellence - Centre for Free Radical Chemistry and Biotechnology. Free radical chemistry is of increasing importance in the manufacture of improved plastics, paints and related materials, in helping restrict oxidative processes that can lead to adverse human health and also to the degradation of important industrial materials. The research will contribute to promoting & maintaining good health by developing new methods for reducing the impacts of ageing as well as in the treatment ....ARC Centre of Excellence - Centre for Free Radical Chemistry and Biotechnology. Free radical chemistry is of increasing importance in the manufacture of improved plastics, paints and related materials, in helping restrict oxidative processes that can lead to adverse human health and also to the degradation of important industrial materials. The research will contribute to promoting & maintaining good health by developing new methods for reducing the impacts of ageing as well as in the treatment of several life-threatening conditions such as stroke. Industrial applications include better surface coatings for preserving metals, and additives to improve the quality and shelf life of beer and wines.Read moreRead less
Microreactors for Organic Synthesis. Since the electronic revolution, miniaturisation has been the trend for devices from consumer electronics to scientific instruments. In this time very little has changed in the manner, or scale, that synthetic organic chemistry has been carried out even though advances in instrumentation mean that less compound is required for identification and analysis. This project aims to bridge the gap by developing recyclable miniaturised reaction vessels for the format ....Microreactors for Organic Synthesis. Since the electronic revolution, miniaturisation has been the trend for devices from consumer electronics to scientific instruments. In this time very little has changed in the manner, or scale, that synthetic organic chemistry has been carried out even though advances in instrumentation mean that less compound is required for identification and analysis. This project aims to bridge the gap by developing recyclable miniaturised reaction vessels for the formation of organic compounds on a scale thousands of times smaller than it is currently done. These devices will have applications in drug discovery programmes due to higher throughput and increased efficiency while minimising waste.Read moreRead less
Natural Product-derived Proteomics Probes for Specific Detection of Protein Kinase C Activities. Better health care depends on how well diseases are understood and how accurately disease analysis and diagnosis can be carried out. This is not only important to disease treatment but also prevention. This project will first generate new compounds that could have improved therapeutic value in cancer treatment. In addition, these compounds will be further engineered to provide a new technology of ....Natural Product-derived Proteomics Probes for Specific Detection of Protein Kinase C Activities. Better health care depends on how well diseases are understood and how accurately disease analysis and diagnosis can be carried out. This is not only important to disease treatment but also prevention. This project will first generate new compounds that could have improved therapeutic value in cancer treatment. In addition, these compounds will be further engineered to provide a new technology of tracing the molecular signature of diseases such as cancer for early detection and better preventative care and treatment. This will create new economic advantage and contributes to the transformation of Australian health care industry.Read moreRead less
Generation of Novel Fermentation Products and their Exploitation in the Synthesis of Biologically Active Organic Compounds with Therapeutic Potential. Collections of new micro-organisms and their metabolites suitable for use in the chemical synthesis programs will emerge from the proposed research. This will provide a potentially highly-valuable national resource that could serve the needs of many laboratories around Australia by allowing them to establish more direct routes to target molecules ....Generation of Novel Fermentation Products and their Exploitation in the Synthesis of Biologically Active Organic Compounds with Therapeutic Potential. Collections of new micro-organisms and their metabolites suitable for use in the chemical synthesis programs will emerge from the proposed research. This will provide a potentially highly-valuable national resource that could serve the needs of many laboratories around Australia by allowing them to establish more direct routes to target molecules being sought in the development of new therapeutic agents and/or materials. The combined application of molecular biological, microbiological and chemical synthesis techniques in a concerted manner in the one location will lead to a raft of new opportunities for the biotech and pharmaceutical industries in Australia. Read moreRead less
Microreactors for Organic Synthesis. Since the electronic revolution, miniaturisation has been the trend for devices from consumer electronics to scientific instruments. In this time very little has changed in the manner, or scale, that synthetic organic chemistry has been carried out even though advances in instrumentation mean that less compound is required for identification and analysis. This project aims to bridge the gap by developing recyclable miniaturised reaction vessels for the format ....Microreactors for Organic Synthesis. Since the electronic revolution, miniaturisation has been the trend for devices from consumer electronics to scientific instruments. In this time very little has changed in the manner, or scale, that synthetic organic chemistry has been carried out even though advances in instrumentation mean that less compound is required for identification and analysis. This project aims to bridge the gap by developing recyclable miniaturised reaction vessels for the formation of organic compounds on a scale thousands of times smaller than it is currently done. These devices will have applications in drug discovery programmes due to higher throughput and increased efficiency while minimising waste.Read moreRead less
ARC Centre of Excellence - Centre for Free Radical Chemistry and Biotechnology. Free radical chemistry is of increasing importance in the manufacture of improved plastics, paints and related materials, in helping restrict oxidative processes that can lead to adverse human health and also to the degradation of important industrial materials. The research will contribute to promoting & maintaining good health by developing new methods for reducing the impacts of ageing as well as in the treatment ....ARC Centre of Excellence - Centre for Free Radical Chemistry and Biotechnology. Free radical chemistry is of increasing importance in the manufacture of improved plastics, paints and related materials, in helping restrict oxidative processes that can lead to adverse human health and also to the degradation of important industrial materials. The research will contribute to promoting & maintaining good health by developing new methods for reducing the impacts of ageing as well as in the treatment of several life-threatening conditions such as stroke. Industrial applications include better surface coatings for preserving metals, and additives to improve the quality and shelf life of beer and wines.Read moreRead less
Australian Marine Biodiversity As A Source Of New Drugs To Control Neurodegenerative Disease. With the aging of Australia's population the impact of neurodegenerative diseases such as Alzheimer's and Parkinson's is rapidly on the rise. There is an urgent need to develop new and better drugs to treat the symptoms and underlying cause of these debilitating diseases. Historically, the majority of the world's pharmaceuticals have been drawn from biodiversity (ie plants, microbes and animals). As one ....Australian Marine Biodiversity As A Source Of New Drugs To Control Neurodegenerative Disease. With the aging of Australia's population the impact of neurodegenerative diseases such as Alzheimer's and Parkinson's is rapidly on the rise. There is an urgent need to develop new and better drugs to treat the symptoms and underlying cause of these debilitating diseases. Historically, the majority of the world's pharmaceuticals have been drawn from biodiversity (ie plants, microbes and animals). As one of the few megabiodiverse nations, Australia is ideally positioned to accelerate and focus the search for drugs from nature. This project will explore an exceptionally promising pool of Australian biodiversity, its marine ecosystems, as a source of inspiration for the development of new drugs to treat neurodegenerative diseases. Read moreRead less
gem-Dihalogenocyclopropanes as building blocks for the chemical synthesis of biologically active natural products and their analogues. New and efficient methods for the assembly of biologically active compounds will emerge from this research and thus provide materials for evaluation as potential therapeutics in the treatment of a range of pathological conditions including Alzheimer's disease and certain types of lung cancers that respond poorly to currently available treatments. The underpinning ....gem-Dihalogenocyclopropanes as building blocks for the chemical synthesis of biologically active natural products and their analogues. New and efficient methods for the assembly of biologically active compounds will emerge from this research and thus provide materials for evaluation as potential therapeutics in the treatment of a range of pathological conditions including Alzheimer's disease and certain types of lung cancers that respond poorly to currently available treatments. The underpinning methodologies are also likely to provide opportunities in other areas, including materials science. The training of a highly capable post-doctoral in chemical synthesis, an area where there is now an extraordinary and unsatisfied demand for such expertise, will be a further benefit of the proposed program of research.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0239044
Funder
Australian Research Council
Funding Amount
$195,000.00
Summary
Next generation organic electronic and optoelectronic device fabrication facility. This application will establish a unique facility to fabricate a new generation of plastic electronic devices. Whilst organic devices have been proposed for several years, a series of breakthroughs in the development of fabrication technologies in the last year have produced novel inexpensive solar cells, lasers, transistors and superconducting electronic devices made from organic materials. At present there is no ....Next generation organic electronic and optoelectronic device fabrication facility. This application will establish a unique facility to fabricate a new generation of plastic electronic devices. Whilst organic devices have been proposed for several years, a series of breakthroughs in the development of fabrication technologies in the last year have produced novel inexpensive solar cells, lasers, transistors and superconducting electronic devices made from organic materials. At present there is no facility to fabricate these devices in Australia, although the potential market for optoelectronic applications exceeds US$12 billion. The proposed facility will enable Australia to actively partake in the development of this new technology at its early stages.Read moreRead less