Generation of Novel Fermentation Products and their Exploitation in the Synthesis of Biologically Active Organic Compounds with Therapeutic Potential. Collections of new micro-organisms and their metabolites suitable for use in the chemical synthesis programs will emerge from the proposed research. This will provide a potentially highly-valuable national resource that could serve the needs of many laboratories around Australia by allowing them to establish more direct routes to target molecules ....Generation of Novel Fermentation Products and their Exploitation in the Synthesis of Biologically Active Organic Compounds with Therapeutic Potential. Collections of new micro-organisms and their metabolites suitable for use in the chemical synthesis programs will emerge from the proposed research. This will provide a potentially highly-valuable national resource that could serve the needs of many laboratories around Australia by allowing them to establish more direct routes to target molecules being sought in the development of new therapeutic agents and/or materials. The combined application of molecular biological, microbiological and chemical synthesis techniques in a concerted manner in the one location will lead to a raft of new opportunities for the biotech and pharmaceutical industries in Australia.Read moreRead less
Taking nature's lead in the development of new and improved enzyme inhibitors. This project will address some key fundamental issues associated with advancing a chemical entity from proof of principle through to a new pharmaceutical. The compounds in the study target cancer, cataract and other diseases that are confronting Australia's ageing population.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989946
Funder
Australian Research Council
Funding Amount
$357,000.00
Summary
High Resolution LC/MS and MALDI for Molecular and Macromolecular Characterisation. The provision of high-resolution and matrix assisted laser desorption ionisation mass spectrometers configured for the molecular and macromolecular research of high quality research groups will lead to earlier and better fundamental discoveries that are directed at important practical developments in medicine, biotechnology, nanotechnology, light-energy harvesting, polymer materials and sensors. These include anti ....High Resolution LC/MS and MALDI for Molecular and Macromolecular Characterisation. The provision of high-resolution and matrix assisted laser desorption ionisation mass spectrometers configured for the molecular and macromolecular research of high quality research groups will lead to earlier and better fundamental discoveries that are directed at important practical developments in medicine, biotechnology, nanotechnology, light-energy harvesting, polymer materials and sensors. These include anticancer agents, nanodevices for drug delivery, better polymers with more energy efficient industrial processes, bioactive molecules for industrially important nitrogen fixation and many more. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668374
Funder
Australian Research Council
Funding Amount
$470,000.00
Summary
State-of-the-art NMR Facilities. This proposal will significantly enhance the NMR research capability and capacities at UoW and ANU. These schools have internationally recognised strengths in fundamentals of synthetic organic chemistry, therapeutic drug design and synthesis, protein chemistry and structural biology. This equipment will enhance the productivity of these researchers, increase their collaborative and scientific outputs and allow for training of students in the latest technologies ....State-of-the-art NMR Facilities. This proposal will significantly enhance the NMR research capability and capacities at UoW and ANU. These schools have internationally recognised strengths in fundamentals of synthetic organic chemistry, therapeutic drug design and synthesis, protein chemistry and structural biology. This equipment will enhance the productivity of these researchers, increase their collaborative and scientific outputs and allow for training of students in the latest technologies and importantly, contribute to Australia's development as a knowledge-based economy.Read moreRead less
The development of a rapid diagnostic test for heparanase activity. Heparanase is an enzyme that has been implicated in a number of disease states such as cancer, arthritis, multiple sclerosis and other inflammatory diseases. Characterisation of this enzyme has been slow, due in part to the lack of a reliable direct activity assay. Using a multi-disciplinary approach, this project seeks to establish a rapid assay that will provide easy determination of heparanase activity. Furthermore, this a ....The development of a rapid diagnostic test for heparanase activity. Heparanase is an enzyme that has been implicated in a number of disease states such as cancer, arthritis, multiple sclerosis and other inflammatory diseases. Characterisation of this enzyme has been slow, due in part to the lack of a reliable direct activity assay. Using a multi-disciplinary approach, this project seeks to establish a rapid assay that will provide easy determination of heparanase activity. Furthermore, this assay could provide a useful diagnostic tool in a clinical environment that would allow for the rapid assessment of these diseases, their progression and indeed response to therapy.Read moreRead less
New fertiliser technologies for sustained food security. This project aims to provide fundamental research to develop next-generation fertiliser products that will improve nitrogen use efficiency, and reduce nitrogen losses in food production systems. It will achieve this goal through a multidisciplinary approach combining experts in synthetic and free radical chemistry, chemical engineering and soil science, with a strong commitment from a fertiliser industry partner. Society is facing the tri ....New fertiliser technologies for sustained food security. This project aims to provide fundamental research to develop next-generation fertiliser products that will improve nitrogen use efficiency, and reduce nitrogen losses in food production systems. It will achieve this goal through a multidisciplinary approach combining experts in synthetic and free radical chemistry, chemical engineering and soil science, with a strong commitment from a fertiliser industry partner. Society is facing the triple challenges of food security, environmental degradation and climate change The availability of new, highly-efficient fertilisers is critical for addressing these challenges, and for the competitive advantage of the Australian fertiliser industry.Read moreRead less
ARC Centre of Excellence - Centre for Free Radical Chemistry and Biotechnology. Free radical chemistry is of increasing importance in the manufacture of improved plastics, paints and related materials, in helping restrict oxidative processes that can lead to adverse human health and also to the degradation of important industrial materials. The research will contribute to promoting & maintaining good health by developing new methods for reducing the impacts of ageing as well as in the treatment ....ARC Centre of Excellence - Centre for Free Radical Chemistry and Biotechnology. Free radical chemistry is of increasing importance in the manufacture of improved plastics, paints and related materials, in helping restrict oxidative processes that can lead to adverse human health and also to the degradation of important industrial materials. The research will contribute to promoting & maintaining good health by developing new methods for reducing the impacts of ageing as well as in the treatment of several life-threatening conditions such as stroke. Industrial applications include better surface coatings for preserving metals, and additives to improve the quality and shelf life of beer and wines.Read moreRead less
Redox-Tuneable Sensitisers for Photodynamic Therapy of Malignant and Non-Malignant Proliferative Diseases. Cancer is currently Australia's leading cause of death with 85 231 new cases reported during 2000, costing the health system >$2 billion annually. Photodynamic Therapy is a promising anti-cancer therapy which combines the action of a photosensitising drug and light to destroy tumours. This project will lead to the development of new photosensitisers which will enable the specific targeting ....Redox-Tuneable Sensitisers for Photodynamic Therapy of Malignant and Non-Malignant Proliferative Diseases. Cancer is currently Australia's leading cause of death with 85 231 new cases reported during 2000, costing the health system >$2 billion annually. Photodynamic Therapy is a promising anti-cancer therapy which combines the action of a photosensitising drug and light to destroy tumours. This project will lead to the development of new photosensitisers which will enable the specific targeting of tumours while protecting healthy tissue from damage. Post-treatment skin photosensitivity will be minimised by antioxidant features integrated into the photosensitisers. The development of improved photosensitisers during this project will ultimately lead to improved treatment and new alternatives for Australian cancer sufferers.Read moreRead less
Developing and applying free radical quantum dots and diamonds: improving the performance of modern artists' paint. As a consequence of the introduction of synthetic materials during the twentieth century, modern works of art are particularly susceptible to free radical mediated deterioration. This project will develop new technology for the detection of free radical damage in these materials, and will inform conservators about their future protection and treatment.
Strategies for the detection of designer steroids in greyhounds. Strategies for the detection of designer steroids in greyhounds. This project aims to develop strategies to detect designer steroids in racing greyhounds to safeguard industry integrity and animal welfare. These strategies include in vivo and comparative in vitro studies of steroid metabolism, mass-spectrometric elucidation of metabolite structures, and synthesis of putative steroid metabolites with different stereochemistries and ....Strategies for the detection of designer steroids in greyhounds. Strategies for the detection of designer steroids in greyhounds. This project aims to develop strategies to detect designer steroids in racing greyhounds to safeguard industry integrity and animal welfare. These strategies include in vivo and comparative in vitro studies of steroid metabolism, mass-spectrometric elucidation of metabolite structures, and synthesis of putative steroid metabolites with different stereochemistries and oxidation patterns as reference materials. This project will use major metabolites identified by these studies to develop analytical procedures to test for drug abuse at greyhound race meetings. The project will target twelve readily available designer steroid supplements that have significant risk of abuse.Read moreRead less