Total Synthesis of Myxobacteria Metabolites and Analogues. This project will investigate the total chemical synthesis of complex myxobacteria metabolites. In addition, the synthesis of new analogues of some of these natural products will also be investigated. The project endeavours to develop new methods for chemical synthesis and also to produce new therapeutic products which may possess greater efficacy and superior biological activities than the natural compounds. Most significantly, this pro ....Total Synthesis of Myxobacteria Metabolites and Analogues. This project will investigate the total chemical synthesis of complex myxobacteria metabolites. In addition, the synthesis of new analogues of some of these natural products will also be investigated. The project endeavours to develop new methods for chemical synthesis and also to produce new therapeutic products which may possess greater efficacy and superior biological activities than the natural compounds. Most significantly, this project will deliver natural and new compounds for analysis of anti-cancer activity. The rewards of the development of new synthetic methods are enormous for the community and in the education of our scientists.Read moreRead less
Development and application of new peptide ligation methods for the synthesis and structure-function studies of glycoproteins. Novel synthetic technologies will be developed in this project to facilitate the preparation of glycoproteins, which are of widespread biological and therapeutic interest. These methods will enable the preparation of pure glycoproteins for detailed biochemical and functional studies eventually leading to therapeutic and diagnostic applications.
Discovery Early Career Researcher Award - Grant ID: DE200100949
Funder
Australian Research Council
Funding Amount
$425,364.00
Summary
Metal-free strategies for sustainable light-driven synthesis. Innovation in synthetic chemistry drives the discovery of new life-saving drugs, agrochemicals and functional materials. This project aims to use visible light to access underexploited reactive intermediates and harness their unique reactivity in new sustainable synthetic transformations. The new chemical processes are expected to deliver increased economy, efficiency and precision in the synthesis of bioactive molecules that are inac ....Metal-free strategies for sustainable light-driven synthesis. Innovation in synthetic chemistry drives the discovery of new life-saving drugs, agrochemicals and functional materials. This project aims to use visible light to access underexploited reactive intermediates and harness their unique reactivity in new sustainable synthetic transformations. The new chemical processes are expected to deliver increased economy, efficiency and precision in the synthesis of bioactive molecules that are inaccessible or challenging to prepare with existing technologies. The conceptual and practical outcomes of this project are expected to benefit both academia and industry as the use of hazardous and expensive metal catalysts can be avoided, reducing chemical waste and simplifying purification.Read moreRead less
Discovering new organic chemistry using an inorganic touch. This project aims to discover new organic chemistry by treating carbon like a metal atom. Advances in fundamental organic chemistry have been important in developing products, including medicines, plastics and television display technology. Much research activity relies on applying existing organic chemistry, but inventing genuinely new organic chemistry is more difficult. By viewing carbon as a metal, this project will try to solve imp ....Discovering new organic chemistry using an inorganic touch. This project aims to discover new organic chemistry by treating carbon like a metal atom. Advances in fundamental organic chemistry have been important in developing products, including medicines, plastics and television display technology. Much research activity relies on applying existing organic chemistry, but inventing genuinely new organic chemistry is more difficult. By viewing carbon as a metal, this project will try to solve important problems in organic chemistry that have been unresolved for decades, and synthesise valuable chemicals normally generated using expensive precious metal catalysts.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC190100034
Funder
Australian Research Council
Funding Amount
$3,574,272.00
Summary
ARC Training Centre for Green Chemistry in Manufacturing. Globally, there is demand for products that are effective, safe and environmentally benign. The ARC Training Centre for Green Chemistry in Manufacturing aims to utilise local and global experts to provide the next generation of Australian chemists and engineers, with skills to develop innovative products and processes that are intrinsically safe and benign. It will provide collaborating partners and the broader manufacturing industry with ....ARC Training Centre for Green Chemistry in Manufacturing. Globally, there is demand for products that are effective, safe and environmentally benign. The ARC Training Centre for Green Chemistry in Manufacturing aims to utilise local and global experts to provide the next generation of Australian chemists and engineers, with skills to develop innovative products and processes that are intrinsically safe and benign. It will provide collaborating partners and the broader manufacturing industry with new products and processes with strong export potential, and the ability to respond to the market pressures, underpinned by green chemistry and sustainable principles. Resulting benefits include increased competitiveness for Australia's manufacturing industry, jobs, social as well as environmental benefitsRead moreRead less
Coinage metal nanoclusters: synthesis, structure and reactivity. Metal catalysts play important roles in the multi-billion dollar production of many industrial and fine chemicals used in wide-ranging applications including pharmaceuticals, insecticides and polymers. Despite the importance of metal catalysed reactions, the molecular details of such processes remain poorly understood. Breakthrough studies highlight that reactions previously thought to be catalysed by discrete metal catalysts are i ....Coinage metal nanoclusters: synthesis, structure and reactivity. Metal catalysts play important roles in the multi-billion dollar production of many industrial and fine chemicals used in wide-ranging applications including pharmaceuticals, insecticides and polymers. Despite the importance of metal catalysed reactions, the molecular details of such processes remain poorly understood. Breakthrough studies highlight that reactions previously thought to be catalysed by discrete metal catalysts are in fact catalysed by metal nanoclusters. This project involves the application of advanced mass spectrometric and computational methods to explore the formation and reactivity of copper, silver and gold nanoclusters. Identification of key reactive intermediates will inform the design of next generation catalysts.Read moreRead less
Defining the biosynthesis and immunological properties of complex bacterial glycolipids. We will study how sugar-lipids are made by industrially, agriculturally and medically important bacteria, and how they interact with the immune system. This will provide new insights into cell wall biosynthesis of importance to the biotechnology industry and identify new reagents for manipulating the immune system.
Developing and applying free radical quantum dots and diamonds: improving the performance of modern artists' paint. As a consequence of the introduction of synthetic materials during the twentieth century, modern works of art are particularly susceptible to free radical mediated deterioration. This project will develop new technology for the detection of free radical damage in these materials, and will inform conservators about their future protection and treatment.
ARC Centre of Excellence - Centre for Free Radical Chemistry and Biotechnology. Free radical chemistry is of increasing importance in the manufacture of improved plastics, paints and related materials, in helping restrict oxidative processes that can lead to adverse human health and also to the degradation of important industrial materials. The research will contribute to promoting & maintaining good health by developing new methods for reducing the impacts of ageing as well as in the treatment ....ARC Centre of Excellence - Centre for Free Radical Chemistry and Biotechnology. Free radical chemistry is of increasing importance in the manufacture of improved plastics, paints and related materials, in helping restrict oxidative processes that can lead to adverse human health and also to the degradation of important industrial materials. The research will contribute to promoting & maintaining good health by developing new methods for reducing the impacts of ageing as well as in the treatment of several life-threatening conditions such as stroke. Industrial applications include better surface coatings for preserving metals, and additives to improve the quality and shelf life of beer and wines.Read moreRead less
Radicals in unconventional media - improving the sustainability of radical reactions through next generation ionic liquid radical chemistry. Despite significant advances over the past few decades, many free radical reactions are still carried out in organic solvents that are often toxic, flammable, difficult to recycle and employ undesirable reagents. It is timely that new free radical chemistry be developed that moves away from this "conventional" landscape. This proposal will develop a fundame ....Radicals in unconventional media - improving the sustainability of radical reactions through next generation ionic liquid radical chemistry. Despite significant advances over the past few decades, many free radical reactions are still carried out in organic solvents that are often toxic, flammable, difficult to recycle and employ undesirable reagents. It is timely that new free radical chemistry be developed that moves away from this "conventional" landscape. This proposal will develop a fundamental understanding of how free radicals interact with, and react in, (unconventional) ionic liquid solvents. This understanding will lead, in turn, to the development of new, more efficient, free radicals methods for the preparation of important materials that include biomolecules. Reduced environmental impact of free radical chemistry is the ultimate aim of this work.Read moreRead less