ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to unde ....ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to understand how single cells react to and communicate with their surroundings. This science will underpin a new generation of devices capable of probing the response of cells within individuals to environmental conditions or treatment, creating innovative and powerful new sensing platforms.Read moreRead less
In vivo mechano-microscopy: a discovery platform for cell mechanics. This project aims to develop a platform for quantitative 3-D imaging of cell elasticity in tissue which may make possible new discoveries in cell mechanics. Mechanical properties, in concert with chemical properties, act to determine the function and behaviour of cells, and play a vital role in diseases such as cancer. Measurement of the mechanical properties of the cell in its native tissue environment, currently not possible, ....In vivo mechano-microscopy: a discovery platform for cell mechanics. This project aims to develop a platform for quantitative 3-D imaging of cell elasticity in tissue which may make possible new discoveries in cell mechanics. Mechanical properties, in concert with chemical properties, act to determine the function and behaviour of cells, and play a vital role in diseases such as cancer. Measurement of the mechanical properties of the cell in its native tissue environment, currently not possible, could accelerate the understanding of cell mechanics. This project plans to develop in vivo mechano-microscopy by combining innovations in optical microscopy, micro-mechanical loading, and computational methods. It then plans to demonstrate its capability by producing the first 3-D elasticity maps of skeletal muscle cells in living animals.Read moreRead less
ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to unde ....ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to understand how single cells react to and communicate with their surroundings. This science will underpin a new generation of devices capable of probing the response of cells within individuals to environmental conditions or treatment, creating innovative and powerful new sensing platforms.Read moreRead less
In vivo mechano-microscopy: a discovery platform for cell mechanics. This project aims to develop a platform for quantitative 3-D imaging of cell elasticity in tissue which may make possible new discoveries in cell mechanics. Mechanical properties, in concert with chemical properties, act to determine the function and behaviour of cells, and play a vital role in diseases such as cancer. Measurement of the mechanical properties of the cell in its native tissue environment, currently not possible, ....In vivo mechano-microscopy: a discovery platform for cell mechanics. This project aims to develop a platform for quantitative 3-D imaging of cell elasticity in tissue which may make possible new discoveries in cell mechanics. Mechanical properties, in concert with chemical properties, act to determine the function and behaviour of cells, and play a vital role in diseases such as cancer. Measurement of the mechanical properties of the cell in its native tissue environment, currently not possible, could accelerate the understanding of cell mechanics. This project plans to develop in vivo mechano-microscopy by combining innovations in optical microscopy, micro-mechanical loading, and computational methods. It then plans to demonstrate its capability by producing the first 3-D elasticity maps of skeletal muscle cells in living animals.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL130100044
Funder
Australian Research Council
Funding Amount
$2,965,000.00
Summary
Controlling light to understand and drive nanoscale processes. This project aims to develop a suite of light-based sensing technologies capable of quantifying the dynamic environment within a living cell. These technologies will extend our capacity to harness light-matter interactions at the nanoscale, providing new insights in fields ranging from plant biology to medicine.
Nanoimaging the cellular architecture of the malaria parasite, Plasmodium falciparum. The immediate benefit of this work will be in the understanding and treatment of malaria - a disease that kills approximately 1 million children annually. The ability to image the three-dimensional structure of cells at high resolution will allow us to ask fundamental questions about the cellular architecture of the malaria parasite and to design novel antimalarial strategies. By developing new methods for cor ....Nanoimaging the cellular architecture of the malaria parasite, Plasmodium falciparum. The immediate benefit of this work will be in the understanding and treatment of malaria - a disease that kills approximately 1 million children annually. The ability to image the three-dimensional structure of cells at high resolution will allow us to ask fundamental questions about the cellular architecture of the malaria parasite and to design novel antimalarial strategies. By developing new methods for correlating structure and elemental location, the work in this proposal will offer a new paradigm for the study of cellular function and disease. This represents an important advance in the suite of investigative tools available to the biotechology sector and will see a corresponding improvement in our understanding of a wide range of disease states.Read moreRead less