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Validation Of A Competency Assessment Method For Persons With Dementia
Funder
National Health and Medical Research Council
Funding Amount
$580,451.00
Summary
Deciding what if any aspects of their financial affairs a person with dementia or suspected dementia can responsibly manage is a difficult process for health and legal professionals as well as for guardianship boards and tribunals. This process is often stressful for the older person, and families can find deciding when to “take over” stressful. Also, having family members manage the older person’s assets may result in family conflict. There is a small amount of overseas research examining this ....Deciding what if any aspects of their financial affairs a person with dementia or suspected dementia can responsibly manage is a difficult process for health and legal professionals as well as for guardianship boards and tribunals. This process is often stressful for the older person, and families can find deciding when to “take over” stressful. Also, having family members manage the older person’s assets may result in family conflict. There is a small amount of overseas research examining this issue. However, no comprehensive and validated method exists internationally or in Australia to determine competency in this context. We will test a methodology for assessing the capacity of individuals to manage their own financial affairs where dementia is an issue. This method involves the use of a number of reliable and well-validated instruments measuring the older person’s mental state, anxiety levels, depression, and social vulnerability combined with an interview exploring the personal circumstances of the older adult in relation to their financial affairs. We will work with the Office of the Adult Guardian in Queensland to recruit participants and to verify both the utility and usability of our methodology with stakeholders (e.g. solicitors, the Office of the Adult Guardian). A comparison will be made between the results obtained in approximately 200 financial competency cases with the competency opinions independently arrived at by the Office of the Adult Guardian in Queensland. As a result of this research, we will be able to ascertain the viability and utility of this assessment method, improve the method as per the data gathered, and ultimately seek future funding to trial the methods across multiple jurisdictions (e.g. other states) and contexts (e.g. various cultural contexts).Read moreRead less
Identification Of Regulatory Protein Interactions On The CRH Promoter
Funder
National Health and Medical Research Council
Funding Amount
$216,600.00
Summary
CRH made in the brain controls our response to stress, and when made by the placenta it controls when birth will occur. Changes to the stress response can have important implications in heart disease, cancer, obesity and many other diseases. 70% of neonatal death is a result of premature birth, and pre-term babies that survive are more likely to have intellectual handicap or cerebral palsy. This research will help us understand CRH production during stress and pregnancy.
Oxygen To Relieve Dyspnoea In Non-hypoxaemic Patients With End-stage Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$445,658.00
Summary
Chronic heart failure is a cause of suffering and a major cause of death in the Australian community. Patients who have chronic heart failure suffer from a range of symptoms that severely impacts every aspect of their life. One of the most common and distressing symptoms is breathlessness. As people with heart failure near death, their breathlessness may worsen not only in terms of its frequency, but also in its intensity. This worsening of symptoms is a source of great distress, both to patient ....Chronic heart failure is a cause of suffering and a major cause of death in the Australian community. Patients who have chronic heart failure suffer from a range of symptoms that severely impacts every aspect of their life. One of the most common and distressing symptoms is breathlessness. As people with heart failure near death, their breathlessness may worsen not only in terms of its frequency, but also in its intensity. This worsening of symptoms is a source of great distress, both to patients as well as their carers and family. Breathlessness is also the most common cause of admission to hospital for patients. A key strategy for managing this distressing symptom in the home is the supply of oxygen. However, due to a lack of scientific evidence for the benefit of home oxygen for people with heart failure, who do not necessarily have low levels of oxygen, it is very difficult for clinicians to access this therapy for their patients. This study seeks to assess if a specific breathlessness action plan alone or if the addition of either oxygen or air can relieve this distressing symptom. The scientific evaluation of these strategies will assist in improving the palliative care of people with chronic heart failure.Read moreRead less
Wounds, burns and scalds are frequent injuries which can lead to deformity, disfigurement and loss of movement. We have shown that the cytoskeletal protein, Flightless I (FliI), is an important regulator of wound repair. We plan to further investigate FliI in wound and burn injuries using new cell-specific transgenic animal models and to develop a new FliI-antibody based therapy to treat wound and burn injuries.
Nutrition And Rehabilitation In Advanced Cancer Patients
Funder
National Health and Medical Research Council
Funding Amount
$225,991.00
Summary
This preliminary project aims to evaluate associations between cancer cachexia, psychosocial factors and cytokine levels in blood. The final decline of most patients with advanced cancer is associated with the cancer cachexia syndrome, triggered in part by cytokine release. Measuring cytokines may enable identification of patients about to enter this final stage. Further, factors like mood and social support appear to alter cytokine levels. The associations established by this study may point to ....This preliminary project aims to evaluate associations between cancer cachexia, psychosocial factors and cytokine levels in blood. The final decline of most patients with advanced cancer is associated with the cancer cachexia syndrome, triggered in part by cytokine release. Measuring cytokines may enable identification of patients about to enter this final stage. Further, factors like mood and social support appear to alter cytokine levels. The associations established by this study may point to treatment options that can delay the terminal phase while improving quality of life.Read moreRead less
This national research centre uniquely combines two recent advances in rehabilitation, applies them to rehabilitation of acquired communication disorder (aphasia) and translates them into a clear pathway for clinical management of people with aphasia. This cell to society research program integrates a consumer's perspective into research in the relearning of lost skills after injury. The resulting Australian Aphasia Clinical Pathway will enable and ensure best practice in aphasia services.
Development And Pre-clinical Evaluation Of A Novel Wound Dressing Treatment For Chronic Ulcers
Funder
National Health and Medical Research Council
Funding Amount
$125,040.00
Summary
Chronic leg ulcers are a common, painful and costly reality for many Australians, impacting on sufferers' mobility, social interactions and overall quality of life. This research is directed at developing a novel cost-effective wound dressing for treatment of this condition. This will be achieved through neutralising the ulcer's toxic proteolytic environment through an interactive wound dressing. This then will allow the body's own cells to promote wound healing.