The Effect Of Overexpression And Underexpression Of Beacon In Transgenic Mice
Funder
National Health and Medical Research Council
Funding Amount
$316,540.00
Summary
Overweight and Obesity are very prevalent in our society. Obesity is the cause of many medical problems including type 2 diabetes, high blood pressure, abnormal lipids, sleep apnoea, arthritis and some cancers. The idea that individuals can freely choose whether they eat or not eat is only true in the short term. Recent work has clearly shown that the desire to eat (hunger) and the decision to stop eating (satiety) are determined by the net level of many chemicals (neurotransmitters) in an area ....Overweight and Obesity are very prevalent in our society. Obesity is the cause of many medical problems including type 2 diabetes, high blood pressure, abnormal lipids, sleep apnoea, arthritis and some cancers. The idea that individuals can freely choose whether they eat or not eat is only true in the short term. Recent work has clearly shown that the desire to eat (hunger) and the decision to stop eating (satiety) are determined by the net level of many chemicals (neurotransmitters) in an area of the brain called the hypothalamus. Malfunction in some of these neurotransmitters has been shown to cause severe obesity in both animals and humans. A clear understanding of how the hypothalamus regulates body weight may lead to treatments for both severe obesity and anorexia. This project deals with investigating the role of a new hypothalamic protein in body weight regulation. This protein called beacon was discovered by one of the chief investigators (GC) who has shown that when it is injected in the brain it causes rats to overeat and put on excess weight. The aim of this project is to produce mice in which the amount of beacon is increased in the brain and other mice who do not have beacon and then to study the impact onthe regulation of body weight.Read moreRead less
Is A Higher Intake Of Omega-3 Fatty Acids Advantageous For Weight Loss?
Funder
National Health and Medical Research Council
Funding Amount
$473,219.00
Summary
A 12 month dietary trial will be conducted to investigate whether a diet that is high in polyunsaturated fat (particularly long chain omega-3 fats found in fish oil) improves weight loss and metabolism, compared to a standard low fat weight-reducing diet. Other benefits of the diet, such as improvements in blood pressure, blood lipids and glucose, will be investigated. The findings will be used to refine dietary advice for weight loss and to develop food products enriched with fish oil.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668543
Funder
Australian Research Council
Funding Amount
$280,000.00
Summary
A high resolution, high-throughput chromatographic system for separation and characterisation of complex samples. Purchase of this equipment will support innovative and collaborative research addressing three of the National Research Priority areas. For example, defining novel drug delivery systems, or the chemical components present in Australia's bioresources, addresses 'Frontier technologies for building and transforming Australian industries', particularly the priority goals of breakthrough ....A high resolution, high-throughput chromatographic system for separation and characterisation of complex samples. Purchase of this equipment will support innovative and collaborative research addressing three of the National Research Priority areas. For example, defining novel drug delivery systems, or the chemical components present in Australia's bioresources, addresses 'Frontier technologies for building and transforming Australian industries', particularly the priority goals of breakthrough science and frontier technologies. The research into trace components in food products, and on fruit fly chemistry, relates to National Research priority four 'Safeguarding Australia', with a priority goal of protecting Australia from invasive diseases and pests. Nutraceutical research addresses the goal of 'Promoting and maintaining good health'.Read moreRead less
Improving eating behaviours in low-income communities. The health, economic and social costs of poor nutrition are substantial. The national partnership, the Strategic Inter-governmental Nutrition Alliance, has proposed a strategy, Eat Well Australia, which aims to improve the well-being of Australians through better nutrition. Fruit and vegetable consumption is an important part of a healthy diet. Increasing Australians' fruit and vegetable consumption will substantially cut health care costs, ....Improving eating behaviours in low-income communities. The health, economic and social costs of poor nutrition are substantial. The national partnership, the Strategic Inter-governmental Nutrition Alliance, has proposed a strategy, Eat Well Australia, which aims to improve the well-being of Australians through better nutrition. Fruit and vegetable consumption is an important part of a healthy diet. Increasing Australians' fruit and vegetable consumption will substantially cut health care costs, improve quality of life, and boost Australia's fresh produce industry. Findings will directly inform an evidence base upon which to design appropriate policies and programs aimed at promoting fruit and vegetable consumption in socioeconomically disadvantaged groups. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346702
Funder
Australian Research Council
Funding Amount
$193,000.00
Summary
High Performance Liquid Chromatography - Inductively Coupled Plasma - Mass Spectrometry (HPLC-ICPMS). HPLC-ICP-MS is the most reliable cutting edge technology for speciation of metals and metalloids in biological and environmental matrices, and is essential for toxicological studies, which is a major aim behind NRCET's establishment. It will provide a very powerful utility to fill a badly needed knowledge gap for our research and serve the needs of both postgraduate students and postdoctoral fel ....High Performance Liquid Chromatography - Inductively Coupled Plasma - Mass Spectrometry (HPLC-ICPMS). HPLC-ICP-MS is the most reliable cutting edge technology for speciation of metals and metalloids in biological and environmental matrices, and is essential for toxicological studies, which is a major aim behind NRCET's establishment. It will provide a very powerful utility to fill a badly needed knowledge gap for our research and serve the needs of both postgraduate students and postdoctoral fellows. This technology will provide new opportunities in research. It will strengthen our linkages within Faculty of Heath Sciences and with our research partners in CQU, QUT and Griffith and enforce our strong national and international reputation.Read moreRead less
MATERNAL UNDERNUTRITION, INFANT REFEEDING, ADIPOSITY AND DIABETES
Funder
National Health and Medical Research Council
Funding Amount
$297,323.00
Summary
Malnutrition is a major health problem throughout the world and one of the priority areas for the WHO. Refeeding program guidelines have been established and implemented when children are assessed as being malnourished. Recent studies on the effect of these important programs throughout the world have suggested they may not have been as successful as wished. Indeed, even though many of the subjects are the urban poor, it has been found that many are developing diabetes in their twenties. This is ....Malnutrition is a major health problem throughout the world and one of the priority areas for the WHO. Refeeding program guidelines have been established and implemented when children are assessed as being malnourished. Recent studies on the effect of these important programs throughout the world have suggested they may not have been as successful as wished. Indeed, even though many of the subjects are the urban poor, it has been found that many are developing diabetes in their twenties. This is associated with an increase in abdominal fatness, out of proportion to the rest of the body's size and shape. The increase in diabetes in this group is most worrying and a major public health problem. It is not known whether the diabetes and abdominal fatness are caused by the refeeding programs or whether they are due to the fact that the body's metabolism was programmed during pregnancy. Perhaps the infants were malnourished whilst they were developing during pregnancy and metabolism was changed so they could store fat easily and not use glucose as readily in the rest of the body. This study is designed to show whether there are metabolic changes which predispose to diabetes and fatness present at birth in those who are malnourished or whether the refeeeding program designed to help them grow is the cause of these later problems.Read moreRead less
Integrative behaviour: a new synthesis. The research will use a uniquely integrative behavioural approach to a) analyse swarming in locusts, and b) apply powerful new models in nutrition to address key problems in biology, agriculture and human health. Outcomes will include i) an understanding of the molecular and environmental mechanisms controlling swarming in locusts, providing new management and control strategies; ii) insights into human obesity, with health policy recommendations; iii) new ....Integrative behaviour: a new synthesis. The research will use a uniquely integrative behavioural approach to a) analyse swarming in locusts, and b) apply powerful new models in nutrition to address key problems in biology, agriculture and human health. Outcomes will include i) an understanding of the molecular and environmental mechanisms controlling swarming in locusts, providing new management and control strategies; ii) insights into human obesity, with health policy recommendations; iii) new technologies for designing nutritional regimes for animal production; iv) an understanding of the responses of insect pests to changing environments; and v) insights into the flow of nutrients across trophic levels within terrestrial ecosystems.Read moreRead less
The Role Of Food Components In The Modification Of Colorectal Cancer Risk At The Epigenomic Level.
Funder
National Health and Medical Research Council
Funding Amount
$28,609.00
Summary
Colorectal cancer represents a substantial burden to the health system. Primary prevention rather than treatment is more cost effective and can reduce morbidity and mortality. This study program will contribute to the emerging research area of nutrigenomics and nutritional epigenomics, by investigating the interaction between nutrition and gene expression. Such research can assist in establishing a diet which can best help to prevent colorectal cancer, at an individual or population level.