Multiscale stochastic modelling of genetic regulatory mechanisms. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will ex ....Multiscale stochastic modelling of genetic regulatory mechanisms. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework for exploring and validating genetic regulatory models in general. This will be used on an exemplar application for understanding the induction process in lambda phage.Read moreRead less
HYBRID METHODS FOR SOLVING LARGE-SCALE OPTIMISATION PROBLEMS. Mathematical modelling and optimisation plays a crucial role in the advancement of modern business, science and technology. A significant benefit of this project is the development of a range of powerful computational tools for improving the productivity of Australian industry, including: agriculture; communications; defence; manufacturing; mining and petroleum; transport and logistics. These tools will be built upon advances in the f ....HYBRID METHODS FOR SOLVING LARGE-SCALE OPTIMISATION PROBLEMS. Mathematical modelling and optimisation plays a crucial role in the advancement of modern business, science and technology. A significant benefit of this project is the development of a range of powerful computational tools for improving the productivity of Australian industry, including: agriculture; communications; defence; manufacturing; mining and petroleum; transport and logistics. These tools will be built upon advances in the fundamental theory developed by the research team. The resulting high quality publications and associated algorithms will greatly enhance Australia's international scientific reputation and provide Australian industry with new cutting-edge optimisation technology.Read moreRead less
Robust methods for hard optimization problems. Highly advanced industrial and information-based societies depend on complex systems that underpin their infrastructure and technologies. Mathematical modelling and optimization techniques are most frequently deployed for the development and refinement of these systems. This project focuses on an important class of difficult optimization problems that arise in many applications. A significant benefit of this project is the development of a number of ....Robust methods for hard optimization problems. Highly advanced industrial and information-based societies depend on complex systems that underpin their infrastructure and technologies. Mathematical modelling and optimization techniques are most frequently deployed for the development and refinement of these systems. This project focuses on an important class of difficult optimization problems that arise in many applications. A significant benefit of this project is the development of a number of robust methods for these hard optimization problems. These methods will be built upon advances in the fundamental theory developed by the research team. The resulting high quality publications and associated algorithms will greatly enhance Australia's international scientific reputation.Read moreRead less