Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668502
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Queensland Computational Grid Enhancement Project. State-of-the-art computational facilities will be made available to enhance research outcomes in vital areas such as environmental and sustainability modelling, security and medical engineering and thus play an important role in advancing scientific and engineering discovery within Queensland and Australia. The new computational systems will be made available on a Queensland wide basis through the Queensland Parallel Supercomputing Foundation an ....Queensland Computational Grid Enhancement Project. State-of-the-art computational facilities will be made available to enhance research outcomes in vital areas such as environmental and sustainability modelling, security and medical engineering and thus play an important role in advancing scientific and engineering discovery within Queensland and Australia. The new computational systems will be made available on a Queensland wide basis through the Queensland Parallel Supercomputing Foundation an initiative supported by Queensland universities and the State Government. The new infrastructure will support more than 390 researchers, is consistent with the national supercomputing framework and directly supports ARC research that addresses all four key national research priorities.Read moreRead less
Quantification of Traffic Generated Nano and Ultrafine Particle Dynamics and Toxicity in Transit Hubs and Transport Corridors. The socio-economic benefits to Australia will include (i) new knowledge for the multiparameter assessment of nano and ultrafine particles, pollutants in the centre of current scientific, medical and policy debates (ii) a breakthrough in the scientific understanding of traffic generated particles in the urban atmosphere (iii) determining the toxicological impact of these ....Quantification of Traffic Generated Nano and Ultrafine Particle Dynamics and Toxicity in Transit Hubs and Transport Corridors. The socio-economic benefits to Australia will include (i) new knowledge for the multiparameter assessment of nano and ultrafine particles, pollutants in the centre of current scientific, medical and policy debates (ii) a breakthrough in the scientific understanding of traffic generated particles in the urban atmosphere (iii) determining the toxicological impact of these particles on biological systems. The ultimate economic benefit will be improved urban design to lower human exposure to ultrafine particles, thus reducing health care cost and productivity losses. The research will also place Australia at the forefront of international progress towards better methods for achieving environmental sustainability.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453501
Funder
Australian Research Council
Funding Amount
$406,097.00
Summary
A Computational Research Grid Serving Regional and Metropolitan Queensland. This project will advance scientific discovery through the development of an integrated, user-friendly computational grid. It significantly enhances Queensland's research capability and infrastructure by delivering state-of-the-art computational resources to researchers at the collaborating institutions and other Queensland and Australia researchers. New supercomputer systems will be integrated into a Queensland wide com ....A Computational Research Grid Serving Regional and Metropolitan Queensland. This project will advance scientific discovery through the development of an integrated, user-friendly computational grid. It significantly enhances Queensland's research capability and infrastructure by delivering state-of-the-art computational resources to researchers at the collaborating institutions and other Queensland and Australia researchers. New supercomputer systems will be integrated into a Queensland wide computational grid being developed by the Queensland Parallel Supercomputing Foundation - an initiative supported by the Queensland State Government. New grid technologies will be employed so that the highest level of support is provided to researchers. This ensures that the facility is used effectively, allowing high-quality research to be efficiently conducted.Read moreRead less
Advanced computational techniques for micro/nano multiscale systems of NEMS/BioMEMS. The outcome of this project will have the following benefits to Australia.
1) It will improve the research level in the area of multiscale simulation of NEMS/BioMEMS;
2) The project will be beneficial to possibly establish new industries in the areas of nanotechnology as well as to make good use of today's microelectronics, mircofabrication and computer technology that have already established in Australia;
....Advanced computational techniques for micro/nano multiscale systems of NEMS/BioMEMS. The outcome of this project will have the following benefits to Australia.
1) It will improve the research level in the area of multiscale simulation of NEMS/BioMEMS;
2) The project will be beneficial to possibly establish new industries in the areas of nanotechnology as well as to make good use of today's microelectronics, mircofabrication and computer technology that have already established in Australia;
3) The manpower trained by this project in the areas of multi-scale simulation of MEMS/NEMS/BioMEMS will provide a crucial support for the future industry of Australia.
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Discovery Early Career Researcher Award - Grant ID: DE120100163
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Modelling and simulation of instabilities in unsaturated soils due to wetting. Ground instabilities due to wetting are a critical issue that will be investigated through this project via the development of risk assessment tools. A rational engineering approach and calculation framework will be developed in order to predict failures and facilitate the design of new safer structures.
Spatio-temporal modelling of Ras dependent MAP kinase activation. This project is at the heart of the national research priority 'Frontier Technologies for Building and Transforming Australian Industries'. Using cutting edge methods and techniques of systems biology, coupled with innovative experimental molecular cell biology we will construct and simulate mathematical models of the EGF-regulated MAP kinase pathway. The project will yield new insights into the fundamental mechanisms of cell sign ....Spatio-temporal modelling of Ras dependent MAP kinase activation. This project is at the heart of the national research priority 'Frontier Technologies for Building and Transforming Australian Industries'. Using cutting edge methods and techniques of systems biology, coupled with innovative experimental molecular cell biology we will construct and simulate mathematical models of the EGF-regulated MAP kinase pathway. The project will yield new insights into the fundamental mechanisms of cell signal transduction that drive cell division, differentiation and transformation and may enable the design of new anticancer therapies. Importantly, the modelling and simulation methods developed in the project will have a general applicability to other complex systems such as sustainable ecological systems.Read moreRead less
Effective and accurate model dynamics, deterministic and stochastic, across multiple space and time scales. A persistent feature of complex systems in engineering and science is the emergence of macroscopic, coarse grained, coherent behaviour from the interactions of microscopic agents (molecules, cells, grains) and with their environment. In current modeling, ranging from ecology to materials science, the underlying microscopic mechanisms are often known, but the closures to translate microscal ....Effective and accurate model dynamics, deterministic and stochastic, across multiple space and time scales. A persistent feature of complex systems in engineering and science is the emergence of macroscopic, coarse grained, coherent behaviour from the interactions of microscopic agents (molecules, cells, grains) and with their environment. In current modeling, ranging from ecology to materials science, the underlying microscopic mechanisms are often known, but the closures to translate microscale knowledge to a system level macroscopic description are rarely available in closed form. Our novel methodology will explore this stumbling block, and promises to radically change the modeling, exploration and understanding of multiscale complex system behaviour.Read moreRead less
Multiscale stochastic modelling of genetic regulatory mechanisms. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will ex ....Multiscale stochastic modelling of genetic regulatory mechanisms. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework for exploring and validating genetic regulatory models in general. This will be used on an exemplar application for understanding the induction process in lambda phage.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101842
Funder
Australian Research Council
Funding Amount
$345,000.00
Summary
New mathematical models for capturing heterogeneity of human brain tissue. This project aims to understand the impact of the heterogeneity of brain tissue on Magnetic Resonance Imaging (MRI) data in both healthy and diseased human brains, and to extract and quantify information on heterogeneity from the data. The project aims to develop novel mathematical and computational approaches to model the heterogeneity of the human brain. The project aims to identify new biomarkers for classifying differ ....New mathematical models for capturing heterogeneity of human brain tissue. This project aims to understand the impact of the heterogeneity of brain tissue on Magnetic Resonance Imaging (MRI) data in both healthy and diseased human brains, and to extract and quantify information on heterogeneity from the data. The project aims to develop novel mathematical and computational approaches to model the heterogeneity of the human brain. The project aims to identify new biomarkers for classifying different brain diseases, based on the extent of heterogeneity across different brain tissue. Results will be validated against extensive MRI scanning data of patients. This project aims to advance state-of-the-art techniques in human brain MRI data analysis.Read moreRead less
Discovery Indigenous Researchers Development - Grant ID: DI0453648
Funder
Australian Research Council
Funding Amount
$144,184.00
Summary
Modelling of coupled heat and water flow through layered soils with an extension to heat flow through granulated soils. The main aim of this project is to develop a mathematical model to simulate coupled heat and water flow through layered soils. The coupling of the two processes will allow us to examine the interaction between heat and water flow. The project also aims to extend the heat component of the flow model to granulated heterogeneous soils by developing a model that encapsulates heat e ....Modelling of coupled heat and water flow through layered soils with an extension to heat flow through granulated soils. The main aim of this project is to develop a mathematical model to simulate coupled heat and water flow through layered soils. The coupling of the two processes will allow us to examine the interaction between heat and water flow. The project also aims to extend the heat component of the flow model to granulated heterogeneous soils by developing a model that encapsulates heat effects at the microscopic and macroscopic level. The model will be applied to two problems 1) hydraulic barriers in cover liner designs for landfills and 2) assessing the ability of heat sensors to measure various soil properties under field conditions.Read moreRead less