Neurological cell replacement therapies: improving outcomes by matching developmental profiles of transplanted cells with the damaged brain area. Stem cell transplantation offers a way to replace nerve cells lost due to acute CNS injury or chronic degenerative conditions such as Parkinson's Disease. However, to date, results have been disappointing because of poor differentiation, survival and integration of stem cells confounded by ethical issues associated with the use of embryos as the source ....Neurological cell replacement therapies: improving outcomes by matching developmental profiles of transplanted cells with the damaged brain area. Stem cell transplantation offers a way to replace nerve cells lost due to acute CNS injury or chronic degenerative conditions such as Parkinson's Disease. However, to date, results have been disappointing because of poor differentiation, survival and integration of stem cells confounded by ethical issues associated with the use of embryos as the source of stem cells. The experiments conducted in this study will provide strategies to improve the efficacy of stem cell transplantation into the damaged CNS as well as developing the use of autologous bone marrow stem cells for repair. Outcomes will be improved transplant methodologies and expertise for the bio-technology industry. Read moreRead less
Vulnerability to cocaine use: discovering common mechanisms conserved across animal phyla. Drug abuse costs Australia an estimated $ 20 billion each year, and research is urgently needed to understand how drugs cause long-term behavioural dysfunction. Our research will identify the basal cellular mechanisms underlying drug abuse and addiction, which are likely to be the best targets for therapies to prevent and cure addiction. Our findings are also relevant to other neuropsychiatric disorders r ....Vulnerability to cocaine use: discovering common mechanisms conserved across animal phyla. Drug abuse costs Australia an estimated $ 20 billion each year, and research is urgently needed to understand how drugs cause long-term behavioural dysfunction. Our research will identify the basal cellular mechanisms underlying drug abuse and addiction, which are likely to be the best targets for therapies to prevent and cure addiction. Our findings are also relevant to other neuropsychiatric disorders related to drug abuse (e.g. depression, anxiety) that are on the increase in Australia. Our work will enhance Australia's reputation for neuroscience research, and will provide training for students in neuropharmacology and molecular neurobiology.Read moreRead less