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Taking nature's lead in the development of new and improved enzyme inhibitors. This project will address some key fundamental issues associated with advancing a chemical entity from proof of principle through to a new pharmaceutical. The compounds in the study target cancer, cataract and other diseases that are confronting Australia's ageing population.
New antibiotics: engaging microbial chemical diversity. This project will explore Australian microbial biodiversity, to detect, isolate and identify new natural chemicals with potent and selective antibacterial properties. Knowledge of these molecules will inspire and inform the development of new classes of antibiotic, effective against multi-drug resistant infections.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100119
Funder
Australian Research Council
Funding Amount
$370,000.00
Summary
Advanced gas chromatography mass spectrometry instrumentation for the analysis of highly complex systems. Advanced instrumentation is required for analysis of the composition of highly complex samples derived from plants, soil, petroleum, water, food and wine. Sample analyses like these form the basis of many applied science research programs. This equipment will offer improved analytical capability and sensitivity, which will enhance the scale and scope of research that can be undertaken.
Bioproduction and bioavailability of steroidal saponins, bioactives in herbal medicines. Steroidal saponins are a class of natural products that are common constituents of many herbal medicines and have been associated with many biological activities. Comprehensive studies into their biological activities are hampered by the small quantities available through isolation and the complexity of synthesis. The aim of this project is to identify, isolate and express the biosynthetic genes responsible ....Bioproduction and bioavailability of steroidal saponins, bioactives in herbal medicines. Steroidal saponins are a class of natural products that are common constituents of many herbal medicines and have been associated with many biological activities. Comprehensive studies into their biological activities are hampered by the small quantities available through isolation and the complexity of synthesis. The aim of this project is to identify, isolate and express the biosynthetic genes responsible for the critical steps in the synthesis of these compounds in the herbs themselves. This will allow for production of steroidal saponins using the isolated enzymes, facilitate biological studies and allow the production of critical standards required by the herbal industry for validation and regulation of herbal extracts.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100229
Funder
Australian Research Council
Funding Amount
$160,000.00
Summary
Time-of-flight mass spectrometer for analysis of complex mixtures in oils, ancient rocks, recent sediments, natural products and atmospheric aerosols. Research benefits will be:1. More effective remediation of petroleum spills through better understanding of degradation pathways, and ecotoxicological impact of spills.
2. Better understanding of the role of urban aerosols in human health impacts and climate change.
3. More effective development of finite petroleum resources by better understand ....Time-of-flight mass spectrometer for analysis of complex mixtures in oils, ancient rocks, recent sediments, natural products and atmospheric aerosols. Research benefits will be:1. More effective remediation of petroleum spills through better understanding of degradation pathways, and ecotoxicological impact of spills.
2. Better understanding of the role of urban aerosols in human health impacts and climate change.
3. More effective development of finite petroleum resources by better understanding of processes altering crude oil in the sub-surface.
4. Identification of natural products from algae, cyanobacteria, plants and mushrooms as new sources of pharmaceutical agents. 5. Improved knowledge of early evolution of life on Earth, helping maintain Australian scientists as world leaders in this field. 6. Greater understanding of the source and migration of petroleum in frontier areas.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101313
Funder
Australian Research Council
Funding Amount
$383,536.00
Summary
New chromatography-electrophysiology methods for semiochemical discovery. The aim of this research is to develop new tools for discovering natural products that mediate insect-insect and plant-insect communication. Knowledge of such semiochemicals is critical for many applications in conservation biology, agriculture, and horticulture. Many of these compounds are difficult to identify with current chemical and electrophysiological methods. The goal is to develop new technology combining state-of ....New chromatography-electrophysiology methods for semiochemical discovery. The aim of this research is to develop new tools for discovering natural products that mediate insect-insect and plant-insect communication. Knowledge of such semiochemicals is critical for many applications in conservation biology, agriculture, and horticulture. Many of these compounds are difficult to identify with current chemical and electrophysiological methods. The goal is to develop new technology combining state-of-the-art chemical separation techniques and electroantennography to enable detection and identification of a broad range of chemicals of biological importance. The intended outcome is to apply this technology to pollination systems of plants of conservation and evolutionary significance, and of commercial importance in terms of insect control and pollination.Read moreRead less
A microbiological platform for the production of complex small molecules with important biological activities. Currently making complex chemicals such as medicines relies on harvesting rare natural resources or using complicated, energy intensive laboratory-based processes. This project will overcome these limitations by using a natural biological system to produce these chemicals, returning significant health and economic benefits to the nation.
Total Synthesis of Myxobacteria Metabolites and Analogues. This project will investigate the total chemical synthesis of complex myxobacteria metabolites. In addition, the synthesis of new analogues of some of these natural products will also be investigated. The project endeavours to develop new methods for chemical synthesis and also to produce new therapeutic products which may possess greater efficacy and superior biological activities than the natural compounds. Most significantly, this pro ....Total Synthesis of Myxobacteria Metabolites and Analogues. This project will investigate the total chemical synthesis of complex myxobacteria metabolites. In addition, the synthesis of new analogues of some of these natural products will also be investigated. The project endeavours to develop new methods for chemical synthesis and also to produce new therapeutic products which may possess greater efficacy and superior biological activities than the natural compounds. Most significantly, this project will deliver natural and new compounds for analysis of anti-cancer activity. The rewards of the development of new synthetic methods are enormous for the community and in the education of our scientists.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100049
Funder
Australian Research Council
Funding Amount
$270,000.00
Summary
Nuclear Magnetic Resonance facility for Northern Australia. Nuclear magnetic resonance facility for Northern Australia: Nuclear magnetic resonance spectroscopy is a fundamentally and critically important technique in the characterisation of organic, inorganic and biological compounds. Research areas that will be supported by this facility include organometallic chemistry and the development of new materials and analytical sensors; organic photochemistry as applied in synthesis and degradation; a ....Nuclear Magnetic Resonance facility for Northern Australia. Nuclear magnetic resonance facility for Northern Australia: Nuclear magnetic resonance spectroscopy is a fundamentally and critically important technique in the characterisation of organic, inorganic and biological compounds. Research areas that will be supported by this facility include organometallic chemistry and the development of new materials and analytical sensors; organic photochemistry as applied in synthesis and degradation; and natural products, pharmaceutical, and inorganic chemistry, where multinuclear nuclear magnetic resonance is most important and applicable in drug design, development and delivery.Read moreRead less